Issues

Summary: This Primer explores different approaches to reprogram somatic cells to induced pluripotent stem cells (iPSCs), mechanistic insights into the reprogramming process, and applications of iPSC technology in development and rejuvenation.

Highlighted Article: This work provides a new insight into how loss of the stimulator of interferon genes impairs lactogenic differentiation during normal mammary gland development.

Highlighted Article: Robust sepal development is preserved despite changes in cell division and is characterized by spatiotemporal averaging of heterogeneity in cell growth rate and direction.

Summary: Hearing and balance depend on specialized ribbon synapses that transmit sensory stimuli between hair cells and afferent neurons. We identify Nrxn3 as a key molecular player in ribbon-synapse maturation in hair cells.

Summary: EnhancerNet, a model for cell identity based on TF-enhancer interactions, explains diverse phenomena and makes specific predictions on large-scale cell identity processes, including differentiation, reprogramming and the evolution of multicellularity.

Summary: Flux in the underlying germ line contributes to complex morphogenesis of the adult hermaphrodite distal tip cell in C. elegans.

Summary: A dynamic interaction between BYN-1 and GLH-1 in the C. elegans germline corresponds with the uptake and clearance of anucleate residual bodies by the surrounding somatic gonad.

Summary: This study illuminates the genetic epistatic relationship and biochemical interaction between Fuz and Gpr161, thereby regulating sonic hedgehog signaling in the context of mouse neural tube development.

Summary: A comprehensive analysis of the first 20 days of mouse skeletal muscle postnatal development focusing on myonuclear positioning and interactions of myonuclei with blood vessels.

Summary: Gα₁₃ is essential for cell polarity and actomyosin dynamics, regulating pharyngeal endoderm morphogenesis by influencing E-cadherin expression and RhoA activation.

Summary: Timely segregation of specific central and peripheral neural fates in quail depends on the concerted activity of a retinoic acid, BMP, Wnt and Notch signaling network.