Issues

Summary: This Review explores how morphogen-mediated patterning and growth evolve, the mechanistic constraints underlying this diversification, and how theory and experiment can be interwoven to bring new perspectives to the field.

Summary: TCF4/Daughterless, a bHLH family transcription factor, is essential for determining whether to move to the next state or stay in the current state in differentiating neuroepithelial cells.

Summary: Single-cell RNA sequencing reveals that first- and higher-order thalamic neurons have distinct differentiation dynamics and developmental sensitivities to peripheral input, highlighting neuron type-specific molecular differentiation programs in the developing thalamus.

Summary: Stabilization of β-catenin on Wnt-mediated induction of mammalian nephron progenitors triggers cadherin-dependent cell aggregation at the onset of a mesenchymal-to-epithelial transition establishing the nephron anlagen.

Summary: Rapid RNA-mediated genetic modification of nephron progenitor cells in vitro reveals dose-dependent responses to canonical Wnt pathway activity in the self-renewal and differentiation of mammalian nephron progenitor cells.

Highlighted Article: Hes1 dynamics in the developing vertebrate embryonic tail reveal distinct oscillation patterns in different tissues: the presomitic mesoderm shows synchronized high amplitudes and the preneural tube shows variable low amplitudes.

Highlighted Article: Deep learning quantification of live-imaging in Drosophila pupal wings shows changes in cell behaviours in response to wound healing when repair signalling pathways are genetically perturbed.

Summary: The DM-domain transcription factor DMD-3 controls chondroitin proteoglycan synthesis, hyperosmotic stress response, suppression of cuticle synthesis and other modules involved in C. elegans male-specific tail tip morphogenesis through multiple transcription factors.

Summary: A previously undescribed non-canonical bivalent gene Wfdc15a that carries H3K4me3 and H3K9me3 in spermatogonial stem cells regulates protease and immune homeostasis during spermatid development in mice.

Highlighted Article: Macrophage recruitment to the angiogenic front promotes pericyte-to-vascular smooth muscle cell transition was organized by tip endothelial FOXO1, a previously unreported role for macrophages during retinal angiogenesis.