Issues

Summary: Studies on mechanosensory neurons from both invertebrates and vertebrates have proven deeply valuable in shaping our understanding of the regulatory players and processes required to terminate axon outgrowth.

Summary: Transcriptional analysis of human blastocysts reveals transcription factors sufficient to derive induced trophoblast stem cells from primed human embryonic stem cells.

Highlighted Article: Use of microfabricated niches reveals that interactions between human hematopoietic progenitors and stromal cells promote asymmetric division of progenitors and boost siblings' heterogeneity, thus contributing to the plasticity of the early steps of hematopoiesis.

Highlighted Article: Establishment of organoids derived from the epithelial cells of the mouse thymus that resemble their in vivo counterpart and have thymopoietic ability in reaggregate culture.

Summary: Mybl2 is a Wnt-regulated transcription factor expressed in the developing inner sulcus domain of the cochlea that influences boundary formation between progenitors and the sensory domain, thereby determining the size of the mature sensory epithelium.

Summary: Lrig1 acts as a homeostatic regulator of glutamatergic cortical neurogenesis by controlling FGF-driven IL6/Jak2/Stat3 proliferative signaling in cortical progenitors that are developmentally specified to give rise to upper-layer projecting neurons.

Highlighted Article: Perturbation of primary cilium function interferes with axon guidance at choice points. The resulting disturbance of neural circuit formation could explain phenotypes seen in some ciliopathy patients.

Highlighted Article: miR-31 post-transcriptionally regulates target transcripts at the mitotic spindle to mediate cytoskeletal dynamics, impacting cell division and early embryonic development.

Highlighted Article: Triggering of trans-pairing by periosteal osteoclasts leads to endocortical bone formation in association with cortical canals in growing long bones.

Summary: Mesenchymal Osr1⁺ cells regulate embryonic lymphatic vessel formation by controlling extracellular matrix and guidance signaling molecules.

Highlighted Article: The first complete loss-of-function mutant in zebrafish involving multiple Akt alleles highlights the necessity of Akt signaling in sustaining the arterial specification and formation of the dorsal aorta through the maintenance of the Notch pathway.

Summary: Conditional loss of gata6 in zebrafish endoderm causes a defect in the accretion of mesoderm-derived secondary heart field cardiac progenitors, leading to a short ventricle and outflow tract abnormalities.