Issues

Summary: This Review provides an overview of the main mechanisms contributing to the Hox spatial-temporal collinearity in vertebrates, from factors triggering Hox initial activation to chromatin topology.

Highlighted Article: KLF6 as a regulator of cholesterol in human radial glia with implications for human brain evolution.

Summary: The isolation of two novel leaf mutants and their cloning reveals a new genetic pathway, involving cytokinins, that suppresses the formation of new shoot meristems during germination in rice.

Summary: Macrophages are abundant in the developing mouse prostate during puberty, associating with nerve fibers and vasculature.

Summary: Manipulation of retinoic acid signalling reveals that trapezius development is dependent on precise spatiotemporal interactions between cranial and somitic mesoderm at the head/trunk interface in mouse.

Summary: Combinatorial multi-omics analyses using ATAC-seq, single-cell RNA-seq and differential bulk RNA-seq increase the resolution of the sea urchin posterior gut gene regulatory network draft for the cells expressing the ParaHox gene Sp-Pdx1.

Summary: In C. elegans motor neurons, a PRD-class homeodomain transcription factor coordinates neurotransmitter biosynthesis in the presynaptic cell with clustering of cognate neurotransmitter receptors at the postsynaptic cell.

Summary: Combinatorial reductions in Pax6 and either the Wingless pathway or the Mirror transcription factor induce a transformation of dorsal head structures into ectopic eyes and antennae.

Summary: Vangl1 and Vangl2 are required in the pulmonary mesenchyme for airway elongation and widening, revealing an explicit role for the mesenchymal compartment in shaping the embryonic airways.

Summary: Loss of Spalt expression in the Drosophila prothoracic gland causes reduced ecdysone production, abnormalities in nucleolar size and nuclear membrane morphology, and reduced ERK phosphorylation and nuclear import.

Summary: Using the fruit fly egg chamber as a model, this study demonstrates that the size and scaling of germline intercellular bridges vary based on lineage.

Summary: Loss of FOXC1 and FOXC2 function in Prx1-expressing limb bud mesenchymal progenitors slows chondrocyte differentiation affecting formation of hypertrophic chondrocytes and the primary ossification center.

Summary: Ebf1 deletion in mice causes deafness, aberrant patterning and innervation of sensory cells, and an increase in the number of hair cells in the cochlea.

Summary: This 3D imaging method provides visual and quantitative means to assess decidual fibrillar collagen deposition, decidualization efficacy, conceptus size, and theoretical prediction of early pregnancy progression in mouse models.

Summary: We describe an improved open-source, flexible and customizable method and complete computational workflow for high-throughput multiplexed in situ transcriptomics, readily applicable to a wide range of tissue types and model organisms.