Issues
-
Cover image
Cover Image
Caption: A confocal maximum intensity projection image created with Imaris showing an E17.5 mouse wild-type mammary gland wholemount stained with epithelial cell marker EpCAM (green), illustrating the non-stereotypical branching pattern that can be tuned by manipulating the Fgf and Tgfβ pathways. See Research article by Satta et al. (dev202179).
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
RESEARCH HIGHLIGHTS
INTERVIEWS
REVIEWS
Compensation of gene dosage on the mammalian X
Summary: This Review focuses on sex-chromosome dosage compensation in mammals, discussing classic and recent hypotheses, observations and mechanisms regarding X-chromosome upregulation and X-chromosome inactivation.
Melanocyte lineage dynamics in development, growth and disease
Summary: This Review summarises the latest advances in understanding how pigment-producing melanocytes develop from the neural crest, Schwann cell progenitors and melanocyte stem cells, and how these mechanisms are co-opted in melanoma.
STEM CELLS AND REGENERATION
Transdifferentiation is temporally uncoupled from progenitor pool expansion during hair cell regeneration in the zebrafish inner ear
Summary: Hair cell regeneration in the zebrafish inner ear occurs through transdifferentiation after a transient wave of supporting cell proliferation that expands the precursor pool.
A large-scale CRISPR screen reveals context-specific genetic regulation of retinal ganglion cell regeneration
Highlighted Article: The identification of 18 genes that regulate retinal ganglion cell regeneration reveals that, owing to a lack of concordance with widespread retinal injury paradigms, some genes function in a context-specific manner during regeneration.
The Drosophila histone methyltransferase SET1 coordinates multiple signaling pathways in regulating male germline stem cell maintenance and differentiation
Summary: Set1 maintains germline activity by ensuring proper JAK-STAT and BMP signaling in the Drosophila testis.
RESEARCH REPORT
Mitochondrial dynamics regulate cell morphology in the developing cochlea
Highlighted Article: Mitochondrial remodelling drives developmental changes in cell morphology in the auditory sensory epithelium. This study reveals a fundamental mechanism regulating cell morphology and frequency-place coding in the developing cochlea.
RESEARCH ARTICLES
Metabolic states influence chicken retinal pigment epithelium cell fate decisions
Summary: Glycolysis drives chicken retina regeneration through RPE reprogramming using glucose, glutamine or pyruvate, whereas pyruvate dehydrogenase activation induces EMT and blocks neural retina fate, influenced by an oxidative environment.
Exploring the principles of embryonic mammary gland branching morphogenesis
Highlighted Article: Quantitative 3D morphometrics, time-lapse imaging, ex vivo mouse embryonic organ cultures and Vangl2-deficient mice reveal that the embryonic mammary epithelial tree forms by both side branching and tip bifurcation events.
Cohesin composition and dosage independently affect early development in zebrafish
Summary: Viable zebrafish mutants show that cohesin complex quantity versus composition leads to different transcriptional and developmental outcomes in the early embryo.
LEAFY and WAPO1 jointly regulate spikelet number per spike and floret development in wheat
Summary: The plant-specific transcription factor LEAFY plays an important role in the regulation of the number of spikelets per spike in wheat.
TECHNIQUES AND RESOURCES
CORRECTIONS
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
