Issues
-
Cover image
Cover Image
Cover: Stylized confocal image of an Arabidopsis thaliana zygote expressing PLETHORA2-YFP (yellow) from its endogenous promoter, a transcription factor coordinating the first cell divisions after fertilization. Cell walls are stained with SCRI Renaissance 2200 (magenta). See Research article by Kerstens et al. (dev202527).
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
RESEARCH HIGHLIGHTS
PERSPECTIVE
INTERVIEWS
SPOTLIGHT
Historic obstacles and emerging opportunities in the field of developmental metabolism – lessons from Heidelberg
Summary: Participants of the 2023 EMBO workshop on Developmental Metabolism outline the zeitgeist of the field by summarizing key technological advances and trends in the scientific mindset.
MEETING REVIEW
Unlocking the potential of SY-stem cells
Summary: This Meeting Review summarizes the talks presented at the sixth SY-Stem Symposium, which took place in Vienna in March 2024, covering topics such as early embryogenesis, nervous system development and disease, regeneration and the latest technologies.
STEM CELLS AND REGENERATION
A transit-amplifying progenitor with biphasic behavior contributes to epidermal renewal
Highlighted Article: Understanding transit amplifying progenitor behavior in-vivo during epidermal homeostasis opens new roads of investigation in stem cell biology, with broad implications for tissue renewal, aging and cancer.
Spermatogonial stem cells in the 129 inbred strain exhibit unique requirements for self-renewal
Summary: Detailed analysis of gene expression to explore self-renewal mechanisms and requirements results in the successful long-term culture of spermatogonial stem cells from the 129 mouse strain.
An updated model of shoot apical meristem regulation by ERECTA family and CLAVATA3 signaling pathways in Arabidopsis
Summary: The transcription factor WUS maintains the stem cell pool in the shoot apical meristem of plants. We examine the role of cell–cell communication in the regulation of WUS transcription.
Local Ecdysone synthesis in a wounded epithelium sustains developmental delay and promotes regeneration in Drosophila
Highlighted Article: Damaged Drosophila epithelia induce a developmental pause by shutting down Ecdysone (Ec) production. Although activity of the Ec receptor drops in uninjured tissues, it rises within regenerating wounds and is required for the regenerative transcriptional program.
RESEARCH ARTICLES
A mathematical framework for measuring and tuning tempo in developmental gene regulatory networks
Highlighted Article: This works presents a mathematical framework to study molecular mechanisms controlling the timing of gene expression during embryo development, enhancing our understanding and design of developmental and synthetic biological circuits.
Mesenchymal Wnts are required for morphogenetic movements of calvarial osteoblasts during apical expansion
Summary: Non-canonical Wnts in the cranial mesenchyme are required for complex calvarial osteoblast cell behaviors and cell movements during apical expansion of frontal bone primordia.
PLETHORA transcription factors promote early embryo development through induction of meristematic potential
Summary: PLETHORA transcription factors induce meristematic potential during early Arabidopsis embryogenesis, which is in strong congruence with their function in maintenance of post-embryonic meristems.
miR-137 confers robustness to the territorial restriction of the neural plate border
Summary: In chick, miR-137 shapes neural plate border development by regulating TFAP2A expression, and is itself regulated by DNMT3A-mediated non-canonical methylation, shedding light on crucial epigenetic mechanisms in vertebrate embryos.
CORRECTION
PREPRINT HIGHLIGHTS
The Company of Biologists Workshops
For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 30 May 2025.
Meet our 2025 Pathway to Independence (PI) fellows
We are delighted to announce our third cohort of PI fellows - researchers whom we will be supporting as they transition from postdoc to Principal Investigator. Read about the eight talented fellows chosen, whom we're excited to be working with as they navigate the job market.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. Together with our preprint highlights service, preLights, these perspectives help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
the Node: Have your say
Our community site, the Node, is conducting a user survey about the content and the design of the site. Help us shape the Node's future and thank you for being a part of the Node over the last 15 years.
