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RESEARCH HIGHLIGHTS

PERSPECTIVE

INTERVIEWS

SPOTLIGHT

Summary: Participants of the 2023 EMBO workshop on Developmental Metabolism outline the zeitgeist of the field by summarizing key technological advances and trends in the scientific mindset.

MEETING REVIEW

Summary: This Meeting Review summarizes the talks presented at the sixth SY-Stem Symposium, which took place in Vienna in March 2024, covering topics such as early embryogenesis, nervous system development and disease, regeneration and the latest technologies.

STEM CELLS AND REGENERATION

Highlighted Article: Understanding transit amplifying progenitor behavior in-vivo during epidermal homeostasis opens new roads of investigation in stem cell biology, with broad implications for tissue renewal, aging and cancer.

Summary: Detailed analysis of gene expression to explore self-renewal mechanisms and requirements results in the successful long-term culture of spermatogonial stem cells from the 129 mouse strain.

Summary: The transcription factor WUS maintains the stem cell pool in the shoot apical meristem of plants. We examine the role of cell–cell communication in the regulation of WUS transcription.

Highlighted Article: Damaged Drosophila epithelia induce a developmental pause by shutting down Ecdysone (Ec) production. Although activity of the Ec receptor drops in uninjured tissues, it rises within regenerating wounds and is required for the regenerative transcriptional program.

RESEARCH ARTICLES

Highlighted Article: This works presents a mathematical framework to study molecular mechanisms controlling the timing of gene expression during embryo development, enhancing our understanding and design of developmental and synthetic biological circuits.

Summary: Non-canonical Wnts in the cranial mesenchyme are required for complex calvarial osteoblast cell behaviors and cell movements during apical expansion of frontal bone primordia.

Summary: PLETHORA transcription factors induce meristematic potential during early Arabidopsis embryogenesis, which is in strong congruence with their function in maintenance of post-embryonic meristems.

Summary: In chick, miR-137 shapes neural plate border development by regulating TFAP2A expression, and is itself regulated by DNMT3A-mediated non-canonical methylation, shedding light on crucial epigenetic mechanisms in vertebrate embryos.

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