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RESEARCH HIGHLIGHTS

INTERVIEWS

SPOTLIGHT

Summary: In the Drosophila nervous system, homeodomain transcription factors play key roles during most, if not all, phases of the developmental process.

MEETING REVIEW

Summary: This Meeting Review summarizes recent research presented at the Cellular and Molecular Mechanisms of Development and Regeneration 2024 conference, which took place at the Shiv Nadar Institute of Eminence and University (India) in February 2024.

PRIMER

Summary: This Primer reviews the genomics, regulation, expression and function of Dlx homeodomain transcription factors – key regulators of the gene regulatory network governing the development of forebrain GABAergic neurons.

HUMAN DEVELOPMENT

Summary: This study generates a high-resolution map of day 3-14 human embryo development by applying a new Entropy Sorting-based feature selection technique to single cell RNA-sequencing data.

STEM CELLS AND REGENERATION

Highlighted Article: Heterogeneities in cell mechanics, growth, function and identity contribute to buckling in clavata mutant shoot apices.

Highlighted Article: Mating increases Ecdysone signaling in soma of the testes that disrupts soma-germline contacts and stem cell cytokinesis but aids in retention of the stem cell pool over time.

RESEARCH ARTICLES

Summary: Mouse GPR124 mutants lacking the intracellular domain exhibit normal developmental cerebral cortex angiogenesis and blood-brain barrier function.

Summary: Gene expression, gene deletion and pathway visualization show that Smad4-dependent signaling is first active after mouse embryo implantation, when it promotes epiblast morphogenesis and scaling, relative to the whole embryo.

Summary: The activation of mRNA translation up to metaphase I in mouse oocytes requires CDK1 phosphorylation but not CPEB1 destabilization.

Summary: TBX3 sets the posterior expression boundaries of anterior genes in mouse limb buds by transcriptional repression and promotes posterior identity together with HAND2.

Summary: LRP4 is required in neurons to instruct diverse aspects of synapse development at the Drosophila neuromuscular junction, highlighting previously unknown presynaptic roles for this receptor at peripheral synapses.

Summary: HIFα proteins are well-known drivers of angiogenesis; however, HIF2α accumulation in PHD2-deficient retinal endothelial cells suppresses retinal angiogenesis in neonatal mice, in part by upregulating DLL4 expression and NOTCH signaling.

TECHNIQUES AND RESOURCES

Summary: Generating a transgenic line based on an endothelial-specific β-catenin chromobody sheds light on the dynamics of endothelial maturation in vascular development.

CORRECTION

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