Skip to Main Content


Skip Nav Destination





Summary: This Review provides an overview of the known regulatory mechanisms and current models for the establishment and maintenance of monoallelic expression, with Xist and olfactory receptors as case studies.

Summary: This Review explores the physical mechanisms underlying cell and tissue elongation and identifies some physical mechanisms of elongation that are conserved across species.


Highlighted Article: Zebrafish Angpt1/Tie1 signaling is demonstrated to be an essential signaling pathway for trunk lymphatic development, with Tie1 regulating Foxo1 localization and modulating Vegfc/Vegfr3 signaling.

Summary: The brain-patterning gene Foxg1 is shown to act as a region-specific, bimodal retrotransposon modulator, limiting transcription of L1 elements and promoting their amplification in the developing rodent CNS.

Summary: The axon guidance molecule Plexin A has two functions in Drosophila medulla development: morphogenesis of the neuropil requires its cytoplasmic domain, but establishing synaptic layers through Semaphorin 1a does not.

Summary: Cell-cell coupling at population level compensates for abnormal dynamic Her6 gene expression at single-cell level, resulting in rescued early development and a mild phenotype at late stages.

Highlighted Article: Insights into how transition of transcriptional states is coordinated along with cell cycle progression during long-distance migration of cell collectives.

Summary: This work demonstrates that patterning and stress cues, both tensile and compressive, are integrated at metaphase to direct the spindle orientation and thus the orientation of cell division.

Summary: EMX2 expression in the otic prosensory domain marks cell lineages corresponding to hair cells of defined stereociliary bundle polarity and restricted to one side of the mouse utricle or saccule.

Highlighted Article: A theoretical framework named Sevilletor shows that the clock and wavefront model with a new self-organizing region can recapitulate the oscillations and excitability observed during mouse somitogenesis.


Summary: Pseudotime analyses of mouse embryonic stem cell-derived dorsal spinal interneurons identifies regulators and lineage relationships between different interneuron populations.

Summary: Normal folate metabolism is disturbed in the absence of the mitochondrial monofunctional enzyme Mthfd1l, causing decreased tissue stiffness during neural tube development and contributing to abnormal neural tube closure.

Highlighted Article: A comprehensive transcriptional atlas of microglia development demonstrating that microglia are necessary for widespread cortical gene expression changes triggered by in utero inflammation.


Close Modal

or Create an Account

Close Modal
Close Modal