Issues
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Cover image
Cover Image
Cover: Drosophila optic lobe at 72 hours after puparium formation. Tm9 neurons are labelled with GMR24C08-GAL4 expressing UAS-myristoylated Tomato (cyan), the medulla, lobula and lobula plate neuropils are labeled with anti-N-cadherin (magenta), and specific layers of these neuropils are labeled with anti-connectin (yellow). Image credit: Maria Bustillo. See Research article by Bustillo et al. (dev202237).
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RESEARCH HIGHLIGHTS
INTERVIEWS
REVIEWS
Establishment and maintenance of random monoallelic expression
Summary: This Review provides an overview of the known regulatory mechanisms and current models for the establishment and maintenance of monoallelic expression, with Xist and olfactory receptors as case studies.
Conserved physical mechanisms of cell and tissue elongation
Summary: This Review explores the physical mechanisms underlying cell and tissue elongation and identifies some physical mechanisms of elongation that are conserved across species.
RESEARCH ARTICLES
Angpt1 binding to Tie1 regulates the signaling required for lymphatic vessel development in zebrafish
Highlighted Article: Zebrafish Angpt1/Tie1 signaling is demonstrated to be an essential signaling pathway for trunk lymphatic development, with Tie1 regulating Foxo1 localization and modulating Vegfc/Vegfr3 signaling.
Foxg1 bimodally tunes L1-mRNA and -DNA dynamics in the developing murine neocortex
Summary: The brain-patterning gene Foxg1 is shown to act as a region-specific, bimodal retrotransposon modulator, limiting transcription of L1 elements and promoting their amplification in the developing rodent CNS.
Two distinct mechanisms of Plexin A function in Drosophila optic lobe lamination and morphogenesis
Summary: The axon guidance molecule Plexin A has two functions in Drosophila medulla development: morphogenesis of the neuropil requires its cytoplasmic domain, but establishing synaptic layers through Semaphorin 1a does not.
Cell coupling compensates for changes in single-cell Her6 dynamics and provides phenotypic robustness
Summary: Cell-cell coupling at population level compensates for abnormal dynamic Her6 gene expression at single-cell level, resulting in rescued early development and a mild phenotype at late stages.
Two sequential gene expression programs bridged by cell division support long-distance collective cell migration
Highlighted Article: Insights into how transition of transcriptional states is coordinated along with cell cycle progression during long-distance migration of cell collectives.
Mechanical stress combines with planar polarised patterning during metaphase to orient embryonic epithelial cell divisions
Summary: This work demonstrates that patterning and stress cues, both tensile and compressive, are integrated at metaphase to direct the spindle orientation and thus the orientation of cell division.
Emx2 lineage tracing reveals antecedent patterns of planar polarity in the mouse inner ear
Summary: EMX2 expression in the otic prosensory domain marks cell lineages corresponding to hair cells of defined stereociliary bundle polarity and restricted to one side of the mouse utricle or saccule.
The Clock and Wavefront Self-Organizing model recreates the dynamics of mouse somitogenesis in vivo and in vitro
Highlighted Article: A theoretical framework named Sevilletor shows that the clock and wavefront model with a new self-organizing region can recapitulate the oscillations and excitability observed during mouse somitogenesis.
TECHNIQUES AND RESOURCES
Investigating the basis of lineage decisions and developmental trajectories in the dorsal spinal cord through pseudotime analyses
Summary: Pseudotime analyses of mouse embryonic stem cell-derived dorsal spinal interneurons identifies regulators and lineage relationships between different interneuron populations.
Optical coherence tomography-guided Brillouin microscopy highlights regional tissue stiffness differences during anterior neural tube closure in the Mthfd1l murine mutant
Summary: Normal folate metabolism is disturbed in the absence of the mitochondrial monofunctional enzyme Mthfd1l, causing decreased tissue stiffness during neural tube development and contributing to abnormal neural tube closure.
Fetal brain response to maternal inflammation requires microglia
Highlighted Article: A comprehensive transcriptional atlas of microglia development demonstrating that microglia are necessary for widespread cortical gene expression changes triggered by in utero inflammation.
CORRECTIONS
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
