Issues
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Cover image
Cover Image
Cover: A Drosophila larval epidermis expressing Hpd::muGFP (green) stained with phalloidin (magenta), marking the muscle. Hpd is an enzyme involved in the tyrosine degradation pathway and is predominantly expressed in the epidermis. Hpd is induced by feeding with a high-protein diet to counteract high-protein toxicity. See Research article by Kosakamoto et al. (dev202372).
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RESEARCH HIGHLIGHTS
EDITORIAL
Choose Development in 2024: serious science, community connections, progressive publishing
Summary: Looking back on Development in 2023 and forwards to 2024, we call on authors to support the community through supporting the journal.
PERSPECTIVES
INTERVIEW
PRIMER
Enabling neighbour labelling: using synthetic biology to explore how cells influence their neighbours
Summary: This Primer reviews emerging approaches for engineering synthetic signalling between cells and discusses how these could be applied to study the influence cells have on their neighbours during development.
REVIEW
Assembly, dynamics and remodeling of epithelial cell junctions throughout development
Summary: This Review explores how the robustness and plasticity of epithelial cell junctions is exploited to enable junctional remodeling while preserving tissue cohesion during development.
STEM CELLS AND REGENERATION
Excess dietary sugar impairs Drosophila adult stem cells via elevated reactive oxygen species-induced JNK signaling
Highlighted Article: Exposure to a high-sugar diet leads to impaired stem cell function in the intestine and ovaries of female Drosophila prior to the onset of insulin resistance. However, tumor stem cells do not respond to a high-sugar diet in the same way as healthy stem cells.
RESEARCH REPORT
Tubb4b is required for multi-ciliogenesis in the mouse
Summary: Tubb4b knockout mice reveal structural defects within the axonemes of multi-cilia.
RESEARCH ARTICLES
Postnatal persistence of hippocampal Cajal-Retzius cells has a crucial role in the establishment of the hippocampal circuit
Highlighted Article: By ablating hippocampal Cajal-Retzius cells in early postnatal development, we demonstrate severe impairments in the development of dendrites and spines of CA1 pyramidal cells, and in synapse-related genes and proteins.
Intercellular contact and cargo transfer between Müller glia and to microglia precede apoptotic cell clearance in the developing retina
Summary: Real-time imaging of developing zebrafish retinas reveals intercellular exchanges between Müller glial cells and with microglia during the clearance of apoptotic cells.
PAR-4/LKB1 prevents intestinal hyperplasia by restricting endoderm specification in Caenorhabditis elegans embryos
Summary: C. elegans PAR-4 and PAR-1 restrict intestinal specification to the E lineage and ensure its robust differentiation by regulating end-1 and elt-2 expression through the SKN-1/MED-1 pathway.
TFAP2 paralogs regulate midfacial development in part through a conserved ALX genetic pathway
Summary: Mouse and zebrafish genetic analyses and next-generation sequencing profiling identify a crucial conserved TFAP2-ALX transcriptional axis within the midface developmental gene regulatory network.
Generation of rat-derived lung epithelial cells in Fgfr2b-deficient mice retains species-specific development
Summary: Rat-derived lungs were generated in an Fgfr2b-deficient mouse model using a tetraploid-based organ complementation method, and the resulting rat lung epithelial cells exhibited species-specific development.
RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration
Summary: Mcf2lb, a RhoA GEF, regulates rosette integrity through modulating apical constriction of cells within rosettes during collective cell migration.
Stimulation of the muscarinic receptor M4 regulates neural precursor cell proliferation and promotes adult hippocampal neurogenesis
Summary: The muscarinic acetylcholine receptor subtype M4 (M4 mAChR) is expressed in a subpopulation of neural precursor cells in the adult mouse hippocampus, where is plays a stage-specific role in neurogenesis.
Epidermal tyrosine catabolism is crucial for metabolic homeostasis and survival against high-protein diets in Drosophila
Summary: Tyrosine catabolism is dynamically regulated in Drosophila epidermal tissue in response to dietary protein intake.
Energy metabolism modulates the regulatory impact of activators on gene expression
Highlighted Article: Mathematical modeling and experimental manipulation of the expression dynamics of yan in Drosophila eye demonstrate that cellular metabolic rate affects gene activation, with a reduced impact of activators under conditions of reduced metabolism.
TECHNIQUES AND RESOURCES
Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology
Summary: The first single-cell multiomic atlas of ocular lens development is presented, lending insights to the detailed regulatory landscape of the cataract-linked transcription factor MAF and the function of PRC2 in cell fate maintenance.
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
