Issues
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Cover image
Cover Image
Cover: Composite of microglia cells of the developing mouse embryo depicting the dynamic gradient between pro- and anti-inflammatory markers, and amoeboid or branched morphology. Pseudocolors reflect these and other non-binary aspect(s) of microglia biology that are influenced by factors released by neural stem cells and newborn neurons during mammalian brain development. See Research article by Mestres and Calegari (dev201574 ).
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RESEARCH HIGHLIGHTS
INTERVIEW
DEVELOPMENT AT A GLANCE
The peripheral nervous system
Summary: This Development at a Glance article provides up-to-date basic knowledge of the anatomical and functional organization of the peripheral nervous system (PNS), with additional insights into the development and cell-type heterogeneity underlying its different roles.
HUMAN DEVELOPMENT
Transplanted human intestinal organoids: a resource for modeling human intestinal development
Summary: Histological and transcriptomic comparison of transplanted human intestinal organoids and human fetal intestinal tissue at different developmental stages reveals that these organoids are an effective tool for modeling human intestinal development.
STEM CELLS AND REGENERATION
The in vivo functional significance of PUF hub partnerships in C. elegans germline stem cells
Summary: Partnerships between PUF RNA-binding proteins and intrinsically disordered proteins are essential for stem cell maintenance and RNA repression in C. elegans.
RESEARCH REPORTS
Microbial pattern recognition suppresses de novo organogenesis
Summary: An experimental system that supports de novo organogenesis in the presence of microbes reveals that recognition of microbial patterns inhibits wound-induced regeneration in plants.
Dysfunction of programmed embryo senescence is linked to genetic developmental defects
Highlighted Article: Analysis of a mouse model of a human congenital syndrome reveals that misregulation of embryo senescence may contribute to genetic developmental disorders, thus expanding the link between cellular senescence and disease.
RESEARCH ARTICLES
Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation
Summary: Mesenchymal cell Gαq/11 signalling regulates myofibroblast function and stretch-mediated TGFβ2 signalling, which are important for alveologenesis and organ homeostasis and could be relevant to both developmental and adult lung disease.
The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis
Summary: DOT1L and MLLT10 are essential for histone H3K79 methylation in germ cells and their inactivation reveals a role for H3K79 methylation in histone eviction during spermiogenesis.
DOT1L promotes spermatid differentiation by regulating expression of genes required for histone-to-protamine replacement
Summary: The H3K79 methyltransferase DOT1L facilitates sperm production by activating expression of genes required for histone-to-protamine exchange, including genes encoding transition proteins, protamines and the testis-specific bromodomain protein BRDT.
A cornichon protein controls polar localization of the PINA auxin transporter in Physcomitrium patens
Summary: The C terminus of the cornichon CNIH2 protein is important for the plasma membrane localization of the PIN auxin transporter in the moss Physcomitrium patens.
Quantitative videomicroscopy reveals latent control of cell-pair rotations in vivo
Highlighted Article: Relative intercellular asymmetry is a crucial factor underlying the robustness of persistently directional collective cell rotations in vivo.
4931414P19Rik, a microglia chemoattractant secreted by neural progenitors, modulates neuronal migration during corticogenesis
Summary: Secretion of the previously uncharacterized protein 4931414P19Rik by neural progenitors is crucial for mediating neuro-immune crosstalk and for regulating neuronal migration during brain development.
A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors
Summary: In vivo transcriptomic and epigenomic profiling reveals Mesp1-independent aspects of early cardiac specification and illustrates a Mesp1-dependent regulatory landscape required for progression through cardiogenesis.
Hemato-vascular specification requires arnt1 and arnt2 genes in zebrafish embryos
Summary: npas4l, arnt1 and arnt2 genes act together to regulate endothelial and hematopoietic cell fate, where each gene is necessary, but by itself not sufficient, to drive hemato-vascular specification.
The Caenorhabditis elegans anchor cell transcriptome: ribosome biogenesis drives cell invasion through basement membrane
Highlighted Article: A transcriptome of an actively invading cell in C. elegans reveals a key role for ribosome biogenesis in expanding translational capacity for pro-invasive protein production.
TECHNIQUES AND RESOURCES
Direct force measurement and loading on developing tissues in intact avian embryos
Highlighted Article: A new feedback-controlled precision technique to measure and alter tissue forces in early avian embryos.
PREPRINT HIGHLIGHTS
The Company of Biologists Workshops
For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 30 May 2025.
Meet our 2025 Pathway to Independence (PI) fellows
We are delighted to announce our third cohort of PI fellows - researchers whom we will be supporting as they transition from postdoc to Principal Investigator. Read about the eight talented fellows chosen, whom we're excited to be working with as they navigate the job market.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. Together with our preprint highlights service, preLights, these perspectives help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
the Node: Have your say
Our community site, the Node, is conducting a user survey about the content and the design of the site. Help us shape the Node's future and thank you for being a part of the Node over the last 15 years.
