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RESEARCH HIGHLIGHTS

INTERVIEW

DEVELOPMENT AT A GLANCE

Summary: This Development at a Glance article provides up-to-date basic knowledge of the anatomical and functional organization of the peripheral nervous system (PNS), with additional insights into the development and cell-type heterogeneity underlying its different roles.

HUMAN DEVELOPMENT

Summary: Histological and transcriptomic comparison of transplanted human intestinal organoids and human fetal intestinal tissue at different developmental stages reveals that these organoids are an effective tool for modeling human intestinal development.

STEM CELLS AND REGENERATION

Summary: Partnerships between PUF RNA-binding proteins and intrinsically disordered proteins are essential for stem cell maintenance and RNA repression in C. elegans.

RESEARCH REPORTS

Summary: An experimental system that supports de novo organogenesis in the presence of microbes reveals that recognition of microbial patterns inhibits wound-induced regeneration in plants.

Highlighted Article: Analysis of a mouse model of a human congenital syndrome reveals that misregulation of embryo senescence may contribute to genetic developmental disorders, thus expanding the link between cellular senescence and disease.

RESEARCH ARTICLES

Summary: Mesenchymal cell Gαq/11 signalling regulates myofibroblast function and stretch-mediated TGFβ2 signalling, which are important for alveologenesis and organ homeostasis and could be relevant to both developmental and adult lung disease.

Summary: DOT1L and MLLT10 are essential for histone H3K79 methylation in germ cells and their inactivation reveals a role for H3K79 methylation in histone eviction during spermiogenesis.

Summary: The H3K79 methyltransferase DOT1L facilitates sperm production by activating expression of genes required for histone-to-protamine exchange, including genes encoding transition proteins, protamines and the testis-specific bromodomain protein BRDT.

Summary: The C terminus of the cornichon CNIH2 protein is important for the plasma membrane localization of the PIN auxin transporter in the moss Physcomitrium patens.

Highlighted Article: Relative intercellular asymmetry is a crucial factor underlying the robustness of persistently directional collective cell rotations in vivo.

Summary: Secretion of the previously uncharacterized protein 4931414P19Rik by neural progenitors is crucial for mediating neuro-immune crosstalk and for regulating neuronal migration during brain development.

Summary: In vivo transcriptomic and epigenomic profiling reveals Mesp1-independent aspects of early cardiac specification and illustrates a Mesp1-dependent regulatory landscape required for progression through cardiogenesis.

Summary: npas4l, arnt1 and arnt2 genes act together to regulate endothelial and hematopoietic cell fate, where each gene is necessary, but by itself not sufficient, to drive hemato-vascular specification.

Highlighted Article: A transcriptome of an actively invading cell in C. elegans reveals a key role for ribosome biogenesis in expanding translational capacity for pro-invasive protein production.

TECHNIQUES AND RESOURCES

Highlighted Article: A new feedback-controlled precision technique to measure and alter tissue forces in early avian embryos.

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