Issues
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Cover image
Cover Image
Cover: Transverse section through the hindbrain level of an E2 chick embryo immunostained for laminin (red) and SOX10 (green). SOX10 is expressed by vagal neural crest cells and neuroepithelial cells forming the otic vesicles. Cell nuclei were stained with DAPI (blue). See Research article by Halasy et al. (dev201289).
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RESEARCH HIGHLIGHTS
EDITORIAL
Keeping up with the Node
Summary: An update on Development's community site the Node, including the appointment of correspondents for both the Node and its sister microscopy site FocalPlane.
PERSPECTIVE
INTERVIEWS
REVIEW
Macrophage-stem cell crosstalk: regulation of the stem cell niche
Summary: In this Review, we characterize the roles of macrophage subtypes in individual regenerative and developmental processes and illustrate the surprisingly direct role for immune cells in coordinating stem cell formation and activation.
HUMAN DEVELOPMENT
A conserved role of the Hippo signalling pathway in initiation of the first lineage specification event across mammals
Highlighted Article: Analysis of the mechanisms involved in the first cell specification event in mouse, rat, cow and human embryos reveals that, despite some expected similarities, mice seem to diverge from other mammals at the molecular level.
STEM CELLS AND REGENERATION
Post-injury born oligodendrocytes incorporate into the glial scar and contribute to the inhibition of axon regeneration
Highlighted Article: Post-injury born oligodendrocytes incorporate into the glial scar and contribute to inhibiting experimentally stimulated axon regeneration within the CNS. They are also susceptible to the demyelination-inducing cuprizone diet, which promotes axon regeneration.
Pten inhibition dedifferentiates long-distance axon-regenerating intrinsically photosensitive retinal ganglion cells and upregulates mitochondria-associated Dynlt1a and Lars2
Summary: A new method for capturing long-distance axon-regenerating RGCs for single-cell RNA-sequencing analysis reveals that adult neuronal subtypes that retain features of the embryonic cell state dedifferentiate in response to a treatment.
RESEARCH ARTICLES
Ratiometric sensing of Pnt and Yan transcription factor levels confers ultrasensitivity to photoreceptor fate transitions in Drosophila
Summary: Using a biophysical model, we demonstrate how a modest change in the Pnt/Yan ratio affects the transition of eye disc cells to photoreceptor cell fates.
The non-canonical Wnt receptor Ror2 is required for cartilage cell polarity and morphogenesis of the craniofacial skeleton in zebrafish
Summary: This paper demonstrates essential roles for the non-canonical Wnt receptors, Ror1 and Ror2, in cartilage morphogenesis in zebrafish.
Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes
Summary: Craniofacial dysmorphology in mouse models of Down syndrome is caused by increased dosage of at least four genes, including Dyrk1a, resulting in reduced proliferation of neural crest-derived cranial bone progenitors.
Foxn1 overexpression promotes thymic epithelial progenitor cell proliferation and mTEC maintenance, but does not prevent thymic involution
Summary: Analysis of K5.Foxn1 transgenic mice reveals that moderate Foxn1 overexpression in progenitor TECs rescues some, but not all, thymic aging phenotypes, and that FOXN1 promotion of TEC proliferation and differentiation is context dependent.
CXCR4 and CXCL12 signaling regulates the development of extrinsic innervation to the colorectum
Highlighted Article: Chimeric tissue recombinations and organ culture assays reveal that CXCR4 and CXCL12 signaling play an essential role in formation of extrinsic innervation of the colorectum, the control of which is poorly understood.
A compound PCP scheme underlies sequential rosettes-based cell intercalation
Summary: A two-component polarity scheme is found to drive sequential rosette formation and resolution during tissue rearrangement in C. elegans embryos.
TECHNIQUES AND RESOURCES
Identification of a heterogeneous and dynamic ciliome during embryonic development and cell differentiation
Summary: A searchable transcriptomic resource for a manually curated primary ciliome, detailing various subgroups of differentially expressed genes within the ciliome that display tissue and temporal specificity.
Next-generation plasmids for transgenesis in zebrafish and beyond
Summary: The generation, validation, and application of several new plasmid vectors suitable for transgenesis in zebrafish and other species.
Development presents…
Development is delighted to host a webinar series showcasing the latest developmental biology and stem cell research. The webinars are held each month with talks from postdocs applying for independent positions as part of our Pathway to Independence programme. Visit Development presents... on the Node to see which stimulating topics are coming up in the next few months.
Meet our 2025 Pathway to Independence (PI) fellows
We are delighted to announce our third cohort of PI fellows - researchers whom we will be supporting as they transition from postdoc to Principal Investigator. Read about the eight talented fellows chosen, whom we're excited to be working with as they navigate the job market.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
Browse by subject
![Development logo - Browse by subject: Explore Development's content, now easily accessible by subject area. The ad has a black background with three vibrant scientific images: a developing embryo on the left, a green plant-like structure in the center, and a gastruloid (a circular cell with a bright pink center and blue outer ring) on the right. [Blue button: browse content].](https://cob.silverchair-cdn.com/ImageLibrary/Development/Snippets/2025_05_Dev_Browse-by-subject_600x230_Snippet.png?versionId=8993)
From cardiovascular development and regeneration to tissue engineering and organoids, Development’s browse by subject archive allows you to access the latest papers (from late 2024 onwards) on a particular field of interest. In addition to our curated subject collections, these subject pages allow readers to browse a broader range of papers organised by topic.
