Issues

Summary: An update on Development's community site the Node, including the appointment of correspondents for both the Node and its sister microscopy site FocalPlane.

Summary: In this Review, we characterize the roles of macrophage subtypes in individual regenerative and developmental processes and illustrate the surprisingly direct role for immune cells in coordinating stem cell formation and activation.

Highlighted Article: Analysis of the mechanisms involved in the first cell specification event in mouse, rat, cow and human embryos reveals that, despite some expected similarities, mice seem to diverge from other mammals at the molecular level.

Highlighted Article: Post-injury born oligodendrocytes incorporate into the glial scar and contribute to inhibiting experimentally stimulated axon regeneration within the CNS. They are also susceptible to the demyelination-inducing cuprizone diet, which promotes axon regeneration.

Summary: A new method for capturing long-distance axon-regenerating RGCs for single-cell RNA-sequencing analysis reveals that adult neuronal subtypes that retain features of the embryonic cell state dedifferentiate in response to a treatment.

Summary: Using a biophysical model, we demonstrate how a modest change in the Pnt/Yan ratio affects the transition of eye disc cells to photoreceptor cell fates.

Summary: This paper demonstrates essential roles for the non-canonical Wnt receptors, Ror1 and Ror2, in cartilage morphogenesis in zebrafish.

Summary: Craniofacial dysmorphology in mouse models of Down syndrome is caused by increased dosage of at least four genes, including Dyrk1a, resulting in reduced proliferation of neural crest-derived cranial bone progenitors.

Summary: Analysis of K5.Foxn1 transgenic mice reveals that moderate Foxn1 overexpression in progenitor TECs rescues some, but not all, thymic aging phenotypes, and that FOXN1 promotion of TEC proliferation and differentiation is context dependent.

Highlighted Article: Chimeric tissue recombinations and organ culture assays reveal that CXCR4 and CXCL12 signaling play an essential role in formation of extrinsic innervation of the colorectum, the control of which is poorly understood.

Summary: A two-component polarity scheme is found to drive sequential rosette formation and resolution during tissue rearrangement in C. elegans embryos.

Summary: A searchable transcriptomic resource for a manually curated primary ciliome, detailing various subgroups of differentially expressed genes within the ciliome that display tissue and temporal specificity.

Summary: The generation, validation, and application of several new plasmid vectors suitable for transgenesis in zebrafish and other species.