Issues

Summary: This Review discusses how recent studies of ribosomopathies have provided insights into the complexity and heterogeneity of ribosome biogenesis and function in developmental processes and cell fate decisions.

Summary: A cyclin mutation suppresses the enlarged shoot meristem and sterility of tso1 mutants, linking a cell cycle regulator to stem cell regulation.

Summary: During Arabidopsis callus formation, a quiescent center-related gene network involving SCR, SHR, WOX5, PLT1 and JKD is required for initiation and maintenance of pluripotent stem cells in the middle cell layer.

Summary: Developmental patterns of gonadal sex determination are investigated using spatiotemporal analysis of supporting cell differentiation and precursor behavior. Testis-specific patterning is explained by intersecting morphogenic and transcriptional organizing principles.

Highlighted Article: Axons of nociceptive neurons impact the modality-specific wiring and subcellular synaptic specificity of touch receptor axons in a Drosophila somatosensory circuit.

Summary: TOX3 overexpression and knockdown studies reveal that it modulates differentiation of the steroidogenic cell population and that its dysregulation may underlie increased steroidogenic capacity, which might lead to polycystic ovarian syndrome.

Highlighted Article: EGF receptor signaling in Drosophila protects epithelial tissues under mechanical stress from collapsing by preventing apical cell extrusion.

Summary: This study reveals a crucial role of canonical Wnt signaling in controlling ciliary homeostasis in CNC-derived palatal mesenchyme to indirectly regulate muscle development in the soft palate.

Summary: Examination of Drosophila Arp6 and H2A.Z mutants reveals that H2A.Z incorporation near the transcription start site, facilitated by the SWR1 component Arp6, is required for rapid activation of proneural target genes.

Summary: Enteric nervous system development relies on migration and proliferation of undifferentiated enteric neural crest-derived cells at the wavefront that are transcriptionally distinct and require DUSP6-mediated signaling for their migration.

Highlighted Article: In addition to its role in the cold temperature response, VIL1 is required for the response to high ambient temperature, involving the modulation of developmental reprogramming by genome-wide H3K27me3 accumulation in Arabidopsis.

Summary: The ubiquitous transcription factor Sp3 is required for the development of gas exchange regions of the lung in addition to controlling expression of multiple cell cycle regulators.

Summary: Multicellular crosstalk regulates the development of the neurovascular complex. Microglial depletion, C3 or C3aR loss reveal that microglia regulate astrocytic and vascular network densities through the C3/C3aR axis during neuroretinal development.