Issues
-
Cover image
Cover Image
Cover: Confocal image of a Drosophila melanogaster larva with dendritic arborization somatosensory neuron dendrites and axons labeled. Dendrites cover the body wall and axons form a ladder-like scaffold that spans the ventral nerve cord at the anterior part of the larva (left in image). Class III gentle touch and class IV nociceptive neurons are labeled green and magenta, respectively. See Research article by Galindo et al. (dev199832).
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
RESEARCH HIGHLIGHTS
INTERVIEWS
REVIEW
Ribosome biogenesis and function in development and disease
Summary: This Review discusses how recent studies of ribosomopathies have provided insights into the complexity and heterogeneity of ribosome biogenesis and function in developmental processes and cell fate decisions.
STEM CELLS AND REGENERATION
Cyclin A participates in the TSO1-MYB3R1 regulatory module to maintain shoot meristem size and fertility in Arabidopsis
Summary: A cyclin mutation suppresses the enlarged shoot meristem and sterility of tso1 mutants, linking a cell cycle regulator to stem cell regulation.
Developmental trajectory of pluripotent stem cell establishment in Arabidopsis callus guided by a quiescent center-related gene network
Summary: During Arabidopsis callus formation, a quiescent center-related gene network involving SCR, SHR, WOX5, PLT1 and JKD is required for initiation and maintenance of pluripotent stem cells in the middle cell layer.
RESEARCH ARTICLES
Biased precursor ingression underlies the center-to-pole pattern of male sex determination in mouse
Summary: Developmental patterns of gonadal sex determination are investigated using spatiotemporal analysis of supporting cell differentiation and precursor behavior. Testis-specific patterning is explained by intersecting morphogenic and transcriptional organizing principles.
Axon–axon interactions determine modality-specific wiring and subcellular synaptic specificity in a somatosensory circuit
Highlighted Article: Axons of nociceptive neurons impact the modality-specific wiring and subcellular synaptic specificity of touch receptor axons in a Drosophila somatosensory circuit.
DMRT1-mediated regulation of TOX3 modulates expansion of the gonadal steroidogenic cell lineage in the chicken embryo
Summary: TOX3 overexpression and knockdown studies reveal that it modulates differentiation of the steroidogenic cell population and that its dysregulation may underlie increased steroidogenic capacity, which might lead to polycystic ovarian syndrome.
Epidermal growth factor receptor signaling protects epithelia from morphogenetic instability and tissue damage in Drosophila
Highlighted Article: EGF receptor signaling in Drosophila protects epithelial tissues under mechanical stress from collapsing by preventing apical cell extrusion.
Canonical Wnt signaling regulates soft palate development by mediating ciliary homeostasis
Summary: This study reveals a crucial role of canonical Wnt signaling in controlling ciliary homeostasis in CNC-derived palatal mesenchyme to indirectly regulate muscle development in the soft palate.
Actin-related protein 6 facilitates proneural protein-induced gene activation for rapid neural differentiation
Summary: Examination of Drosophila Arp6 and H2A.Z mutants reveals that H2A.Z incorporation near the transcription start site, facilitated by the SWR1 component Arp6, is required for rapid activation of proneural target genes.
A distinct transcriptome characterizes neural crest-derived cells at the migratory wavefront during enteric nervous system development
Summary: Enteric nervous system development relies on migration and proliferation of undifferentiated enteric neural crest-derived cells at the wavefront that are transcriptionally distinct and require DUSP6-mediated signaling for their migration.
Warm temperature-triggered developmental reprogramming requires VIL1-mediated, genome-wide H3K27me3 accumulation in Arabidopsis
Highlighted Article: In addition to its role in the cold temperature response, VIL1 is required for the response to high ambient temperature, involving the modulation of developmental reprogramming by genome-wide H3K27me3 accumulation in Arabidopsis.
Sp3 is essential for normal lung morphogenesis and cell cycle progression during mouse embryonic development
Summary: The ubiquitous transcription factor Sp3 is required for the development of gas exchange regions of the lung in addition to controlling expression of multiple cell cycle regulators.
Microglia refine developing retinal astrocytic and vascular networks through the complement C3/C3aR axis
Summary: Multicellular crosstalk regulates the development of the neurovascular complex. Microglial depletion, C3 or C3aR loss reveal that microglia regulate astrocytic and vascular network densities through the C3/C3aR axis during neuroretinal development.
Save the date - Human Development: Stem Cells, Models, Embryos

We will be hosting a 2026 Human Development: Stem Cells, Models, Embryos meeting. We have teamed up with the Wellcome-funded consortium, the Human Developmental Biology Initiative (HDBI) to co-organise this event, which will bring together researchers from around the world, united by an interest in understanding human developmental biology. Save the date for 7-9 September 2026 and register.
Development presents…

Development is delighted to host a webinar series showcasing the latest developmental biology and stem cell research. The webinars are held each month with talks from postdocs applying for independent positions as part of our Pathway to Independence programme. Visit Development presents... on the Node to see which stimulating topics are coming up in the next few months.
Meet our 2025 Pathway to Independence (PI) fellows

We are delighted to announce our third cohort of PI fellows - researchers whom we will be supporting as they transition from postdoc to Principal Investigator. Read about the eight talented fellows chosen, whom we're excited to be working with as they navigate the job market.
From bench to business

In this Perspective, researchers who have transitioned from academia to industry tell us how they have navigated patents, intellectual property, investors and biotechnology start-ups to bring new biological advances from the bench and into the boardroom.
Browse by subject
![Development logo - Browse by subject: Explore Development's content, now easily accessible by subject area. The ad has a black background with three vibrant scientific images: a developing embryo on the left, a green plant-like structure in the center, and a gastruloid (a circular cell with a bright pink center and blue outer ring) on the right. [Blue button: browse content].](https://cob.silverchair-cdn.com/ImageLibrary/Development/Snippets/2025_05_Dev_Browse-by-subject_600x230_Snippet.png?versionId=9135)
From cardiovascular development and regeneration to tissue engineering and organoids, Development’s browse by subject archive allows you to access the latest papers (from late 2024 onwards) on a particular field of interest. In addition to our curated subject collections, these subject pages allow readers to browse a broader range of papers organised by topic.