Issues

Summary: Mayssa Mokalled discusses how she became interested in developmental biology and tissue regeneration, and the importance of mentoring and collaboration across disciplinary fields.

Summary: A brief overview of the Notch signaling pathway and its molecular activation mechanism, discussing different examples of Notch-mediated coordination of differentiation between neighboring cells during development and homeostasis.

Summary: This Primer of the reproductive genomics of the mouse covers single-gene and quantitative fertility traits affecting gametogenesis and gamete function, and discusses new genetic resources and their translational applications.

Highlighted Article: Three-dimensional region-specific organoids reveal that 16p11.2 deletion increases variability and prolongs the cell cycle of human subpallial progenitors by lengthening their G1 phase.

Highlighted Article: Hoxa11 expression marks a population of muscle interstitial cells capable of an extensive satellite cell-independent contribution to skeletal muscle fibers during adult homeostasis.

Summary: Molecular mechanisms for tripartite synapse formation were revealed using a newly developed in vitro co-culture system for mouse astrocytes and neurons.

Highlighted Article: Lingual epithelial stem cells variably express the transcription factor SOX2. Cells with high, but not low, SOX2 are taste competent and give rise to taste bud cell-replete organoids in vitro.

Summary: In vivo proximity labeling of Zucchini, an endonuclease for piRNA biogenesis, in Drosophila ovary.

Summary: Maternal Prc1l is required for microtubule reorganization involved in cell division and the segregation of dorsal determinants in the early zebrafish embryo.

Summary: Protein phosphatase A, which regulates internal cell organisation in plants and animals, controls cell identity in a brown alga. highlighting functional conservation across a billion years of eukaryotic evolution.

Summary: Frizzled 7 deletion interrupts the differentiation of stem cells and changes the cell distribution of intestinal epithelium, which drives tissue damage in intestines.

Summary: The testis-enriched translation initiation factor eIF4E-5 contributes to spermatid cyst polarization and is needed for individualization of mature sperm and male fertility in Drosophila.

Summary: Novel monoclonal antibodies to Xenopus laevis proteins have been generated and characterized using refined hybridoma production methods suitable for basic science research laboratories.

Summary: An intersectional genetic approach is used to develop engineered mice to simultaneously label cellular subtypes and knock out specific genes in vivo.