Issues

Summary: This Meeting Review provides an overview of the exciting topics discussed during the eighth EMBO conference in the series ‘The Molecular and Cellular Basis of Regeneration and Tissue Repair’ held in September 2022.

Summary: This Review summarises mechanisms of Wnt ligand export and recent structural insights, with a focus on the Wnt transport protein Evi/Wntless.

Highlighted Article: Autosomal dominant Robinow syndrome is successfully modeled in mice for the first time and a therapeutic intervention strategy established for potential translation to human patients.

Highlighted Article: The bHLH transcription factor HAND2 regulates key gene regulatory networks within the developing endocardium and its DNA occupancy within regulated genes is predictive of transcriptional enhancers.

Summary: Inflorescence stem mechanical integrity relies on coordinated cell growth in inner tissues and physical support provided by vascular bundles.

Summary: CNKSR2 is a previously unreported downstream mediator of RA signaling that modulates the Ras/Raf/MEK pathway for inducing roof plate marker expression during midline invagination of the chick forebrain roof plate.

Highlighted Article: A crucial role is revealed for hnRNPH1 in SCs during spermatogenesis and a potential molecular regulatory network invoving hnRNPH1 in establishing Sertoli–germ cell crosstalk.

Summary: Cell-like arrays in self-organizing egg extracts feature a dynamically coarse-graining geometry similar to two-dimensional foams without long-range order. Similar results from embryos and tissues suggest common principles of space compartmentalization.

Summary: Unbiased phenotyping of the mouse hypothalamus using single-cell RNA sequencing reveals the crucial role of early postnatal thyroid hormone receptor α1 signaling for hypothalamic oligodendrocyte maturation.

Highlighted Article: TAT-Cre microinjection can be used to trace cell lineages and edit genes at custom anatomical locations in postimplantation mouse embryos, allowing prospective clonal analysis and genetic mosaic studies in progenitor cell populations.

Summary: GliaMorph allows for multi-dimensional Muller glial cell analysis, enabling image-level as well as subcellular morphological assessments that are robust, adaptable and easy to use.