Issues
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Cover image
Cover Image
Cover: Human bronchial epithelial (NHBE) cells, stained by immunofluorescence for phalloidin (labelling F-actin) in turquoise, E-cadherin in green and ZO-1 in red with slightly adjusted intensities for artistic effect. See Research article by Peterson et al. (dev201893).
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RESEARCH HIGHLIGHTS
DEVELOPMENTAL TWISTS
PERSPECTIVE
SPOTLIGHT
Programming human cell fate: overcoming challenges and unlocking potential through technological breakthroughs
Summary: Advances in human cell programming offer the potential to manipulate cell identity and function but face many challenges. Recent breakthrough technologies hold promise for more precise and efficient cell engineering.
REVIEW
Endothelin signaling in development
Summary: This Review covers the role of endothelin signaling during craniofacial, cardiovascular, melanocyte and enteric nervous system development and describes the evolutionary conservation of endothelin action and implications to human health.
STEM CELLS AND REGENERATION
An EMC–Hpo–Yki axis maintains intestinal homeostasis under physiological and pathological conditions
Highlighted Article: The evolutionarily conserved endoplasmic reticulum membrane protein complex controls intestinal stem cell proliferation in Drosophila by associating with and stabilizing Hippo protein under physiological and pathological conditions.
In toto imaging of glial JNK signaling during larval zebrafish spinal cord regeneration
Summary: Kinase translocation reporters can be used to quantify JNK activity at single-cell resolution in spinal cord glia of live zebrafish, identifying a requirement for this pathway in spinal cord regeneration.
In situ regeneration of inner hair cells in the damaged cochlea by temporally regulated co-expression of Atoh1 and Tbx2
Summary: New inner hair cells can be effectively regenerated from supporting cells in the pre-damaged cochlea.
RESEARCH ARTICLES
On the origins of developmental robustness: modeling buffering mechanisms against cell-level noise
Summary: New and existing hypotheses on buffering mechanisms against cell-level noise are evaluated using EmbryoMaker.
Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease
Summary: Defective centrosome biogenesis in kidney progenitors blocks their growth and causes premature differentiation, resulting in abnormal branching morphogenesis, reduced nephron formation and small kidneys that become fibrotic and cystic.
Sall1 and Sall4 cooperatively interact with Myocd and SRF to promote cardiomyocyte proliferation by regulating CDK and cyclin genes
Summary: Analysis of heart-specific functional inhibition of Sall1 and Sall4 in mice reveals their importance in cardiomyocyte proliferation by regulating cyclin genes that interact with myocardin and serum response factor.
Caenorhabditis elegans germ granules are present in distinct configurations and assemble in a hierarchical manner
Summary: Quantification of the relationships between C. elegans germ granule compartments establishes a more accurate model of germ granule assembly, compartment hierarchy, and interaction with nuclear pores and RNA.
Toll-like receptor signalling via IRAK4 affects epithelial integrity and tightness through regulation of junctional tension
Summary: The kinase IRAK4, downstream of TLRs, maintains epithelial tightness and integrity at steady state in human tissue culture models, with inhibition or loss of IRAK4 leading to loss of tension and changes in components at tight junctions.
Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis
Summary: Loss of NR5A1 after the sex determination period causes Sertoli cells to revert to supporting progenitor-like cells and transdifferentiate into pre-granulosa-like cells that die by a Trp53-independent mechanism.
GRD-1/PTR-11, the C. elegans hedgehog/patched-like morphogen-receptor pair, modulates developmental rate
Summary: C. elegans deficient in nutrient-sensitive target of rapamycin complex 2 signaling demonstrate significantly slowed growth and delayed development that converges on a pathway regulated by hedgehog/patched-like signaling.
ARRDC5 deficiency impairs spermatogenesis by affecting SUN5 and NDC1
Summary: Mass spectrometry reveals that ARRDC5 anchors the sperm head to the tail during spermatogenesis by facilitating SEC22A-mediated transport of NDC1 and SUN5.
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
