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Special Issue: Metabolic and Nutritional Control of Development and Regeneration




Summary: HEXOKINASE1 is a crucial regulator of plant development. In this Spotlight, we discuss the vital role of HEXOKINASE1 catalytic activity and glucose-6-phosphate production in plant growth and senescence.

Summary: This Spotlight gives an overview of the role of nutritional and metabolic cues during development, across different species and multiple levels of complexity. 


Summary: This Development at a glance article summarizes insulin hormone family signaling and highlights the roles of individual hormones in regulating growth, cell proliferation and differentiation.


Summary: This Review provides an overview of the remarkable roles that metabolism and metabolic switches play during development, differentiation and regeneration.

Summary: This Review highlights mechanisms by which metabolism supports developmental biology beyond cell growth and energy to include differentiation, signaling, cell behavior and organismal maturation in multiple model systems.

Summary: Precise metabolism reprogramming is essential for successful establishment of pre-implantation embryo fate and ensures early mammalian embryogenesis by maintaining energy and epigenetic homeostasis.

Summary This Review summarizes emerging evidence that cardiometabolic diseases in offspring arise from changes in placental development and function and discusses mechanisms of cross-talk between the mother and fetus via the placenta.

Summary: This Review highlights recent mechanistic insights into how common diets and specific nutrients impact developmental processes and cell fate decisions in healthy and disease contexts.


Summary: L-proline acts as growth factor to modulate phosphorylation of the Mapk, Pi3k, Fgf and mTor signalling pathways to drive embryonic stem cells to primitive ectoderm-like cells.

Summary: An auxin-regulated class VIII myosin, ATM1, is required for root cell proliferation in response to sugar.

Summary: The fish-specific translation initiation factor Eif4e1c, which is absent in terrestrial species, regulates growth and heart regeneration in zebrafish.

Summary: Shmt, a key player in one-carbon metabolism, is essential for optic lobe development, and its loss leads to neuroepithelia apoptosis and morphological defects with consequent loss of neuroblasts and neurons.

Summary: Measuring the amino acid requirements of germline stem cells reveals that spermatogonia require glutamine for protection against reactive oxygen species.


Summary: A high-sugar diet, but not obesity, impairs female fertility in Drosophila, highlighting the importance of distinguishing diet versus obesity effects in studies involving obesity.

Summary: Using mouse genetics and human neural organoids, we assessed the consequences of reducing the activity of a metabolic enzyme, DHFR, on the production of different neuronal subtypes during neocortex development.

Summary: Heme-deficient primitive RBCs induced HSPC ferroptosis through the disruption of iron trafficking, and the iron-ROS-lipid peroxidation axis is responsible for defective HSPC production.

Summary: Genetic and lipid studies reveal that the lipid droplet-associated Adipose Triglyceride Lipase provides the substrate for prostaglandin production during Drosophila follicle development, ultimately regulating actin remodeling and promoting fertility.

Summary: Transgenic, micromorphological, dynamic and multi-omic analyses in wheat reveal the underlying mechanism of the Green Revolution gene Rht-B1b in modulation of plant architecture and yield component traits.

Summary: Supplementation of the intermediate metabolite SAM in the methionine metabolic pathway alleviates damaged intestinal epithelium and inflammatory infiltration caused by IEC-specific deletion of Mat2a and partly ameliorates the DSS-induced colitis.

Summary: In Drosophila embryos, Jabba is essential for correct sorting of glycogen granules and lipid droplets into different tissues by preventing inappropriate interactions between these organelles.

Summary: Gestational iron deficiency leads to altered neuronal progenitor cell proliferation in the embryo and is associated with changes in specific interneuron subtypes in the offspring.

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