Issues
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Cover image
Cover Image
Cover: A cross-section of the nasal cavity of a 2-month-old wild-type mouse showing healthy olfactory mucosa. Yellow marks cilia and magenta marks nuclei. See Research article by Habif et al (dev201116).
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RESEARCH HIGHLIGHTS
INTERVIEWS
DEVELOPMENT AT A GLANCE
Germ granules in development
Summary: A survey of germ granules across organisms and developmental stages, highlighting emerging themes regarding granule regulation, dynamics and proposed functions.
REVIEW
Optic cup morphogenesis across species and related inborn human eye defects
Summary: This Review analyses the common principles by which vertebrates generate overall similar cup-shaped eyes, pointing to relevant differences and discussing the relationship with congenital eye malformations.
STEM CELLS AND REGENERATION
The adult Drosophila testis lacks a mechanism to replenish missing niche cells
Summary: Non-dividing niche cells in the adult Drosophila testis, which are able to divide to replace missing stem cells, are unable to replace themselves.
NANOGP1, a tandem duplicate of NANOG, exhibits partial functional conservation in human naïve pluripotent stem cells
Highlighted Article: Establishing that NANOGP1 has retained partial functional conservation with its ancestral copy NANOG sheds light on the role of gene duplication and subfunctionalisation in human pluripotency and development.
RESEARCH REPORTS
Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling
Summary: Adar1 prevents aberrant activation of the Mavs-mediated innate immune pathway in the pancreas, thereby maintaining pancreatic homeostasis.
Primordial germ cells adjust their protrusion type while migrating in different tissue contexts in vivo
Highlighted Article: Germ cells migrating in vivo alter the dynamic parameters of the protrusions they form in different cellular contexts and respond to differences in cortical tension in neighboring cells.
RESEARCH ARTICLES
Psi promotes Drosophila wing growth via direct transcriptional activation of cell cycle targets and repression of growth inhibitors
Summary: Psi orchestrates wing growth in Drosophila via direct transcriptional activation of pro-proliferative genes in combination with repression of growth inhibitory pathways.
The centralspindlin complex regulates cytokinesis and morphogenesis in the C. elegans spermatheca
Summary: In Caenorhabditis elegans, the centralspindlin complex components CYK-4 and ZEN-4, together with RHO-1 and CDC-42, shape the spermatheca by controlling the completion of cytokinesis.
The role of a ciliary GTPase in the regulation of neuronal maturation of olfactory sensory neurons
Summary: ARL13B, a protein enriched in a signaling hub (cilia), is required for the maturation of neurons in the mouse nose and its loss impairs smell.
Actomyosin-mediated cellular tension promotes Yap nuclear translocation and myocardial proliferation through α5 integrin signaling
Summary: ROCK-regulated nonmuscle myosin contractility couples signals from integrin to Yap in an integrated mechanochemical signaling system to ultimately control cardiomyocyte proliferation in the newborn mouse heart.
Src42A is required for E-cadherin dynamics at cell junctions during Drosophila axis elongation
Summary: The non-receptor tyrosine kinase Src42A regulates embryonic axis elongation by multiple mechanisms, including the control of E-cadherin dynamics at adherens junctions.
The AKT1-FOXO4 axis reciprocally regulates hemochorial placentation
Summary: Genome-edited rat models reveal that the kinase AKT1 and the AKT1 substrate FOXO4 act in a reciprocal manner to regulate development of the hemochorial placenta.
Ikaros family proteins redundantly regulate temporal patterning in the developing mouse retina
Summary: How different neuronal cell types are produced at specific times during development remains unclear. This study provides evidence that the zinc-finger protein Ikzf4 contributes to temporal patterning in the retina.
TECHNIQUES AND RESOURCES
De novo PAM generation to reach initially inaccessible target sites for base editing
Summary: A combinatorial and sequential one-shot approach termed ‘inception’ is a twist on base editing that allows initially inaccessible nucleotides to be reached.
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
