Issues

Summary: This Review describes the tissue-resident gastric stem cell population that drives stomach patterning and lineage specification during development and continued homeostatic maintenance and regeneration in adulthood.

Summary: alx-3 plays an essential role in integrating wound signals, priming neurogenesis and successful head regeneration.

Summary: Perturbation of glia with ets-1(RNAi) alters neuronal gene expression, impedes animal movement and impairs nervous system architecture in planarians.

Highlighted Article: The mechanisms of Wnt signaling in butterfly wings, identifying Frizzled2 as a receptor for WntA that mediates major effects on color pattern induction.

Summary: The kinesin-1 heavy chain promotes the localization and motility of the NEKL-3 kinase in axons. This process is required for axon targeting and its disruption may cause neurodevelopmental disorders.

Summary: The first molecular description of pupal Drosophila blood cells provides insights into blood cell functional diversification and plasticity during metamorphosis, a phase marked by programmed cell death and inflammatory signals.

Summary: The role of wnt9a/b in assembly of myocardial progenitor cells at the embryonic midline to form the heart cone and then initiate leftward-directed heart tube elongation.

Highlighted Article: Transcriptomic and epigenomic analyses of Drosophila mutants reveals that, in the absence of Pc, the eye is reprogrammed into a wing through inappropriate formation of the Vestigial–Scalloped complex.

Highlighted Article: Loss of balanced retinoic acid signaling from the meninges causes cortical folding due to regionalized changes to neurogenesis that affect the tangential distribution of neurons and cortical expansion.

Summary: Longitudinal live imaging of zebrafish skin development revealed an active traveling wave coupled to cellular processes as a mechanism for producing periodic patterning of skin appendages.

Summary: The first report indicating that tongue mesenchyme is required for taste papilla cell differentiation.

Summary: The neuronal furin-like proprotein convertase KPC-1 in Caenorhabditis elegans requires catalytic activity to non-autonomously regulate the Menorin adhesion complex from adjacent tissues, thereby providing negative feedback during dendrite development.

Summary: An acytokinetic cell division breaks the initial membrane symmetry in embryonic garland nephrocytes creating PIP2-enriched membrane microdomains suitable for slit diaphragm assembly.

Highlighted Article: Loss of Rasa1 in zebrafish leads to cavernous arteriovenous malformations with venous-specific increased MEK/ERK activity and cell size, and disrupted angiogenesis and blood flow.

Summary: Examination of the migration and morphogenesis of Drosophila visceral muscle precursors reveals how these multinucleated precursors form the stereotypic arrangement of longitudinal gut muscles and identifies Tey as a crucial regulator of this process.

Summary: Dynamic expression of Zbtb16 underlies downregulation of early segmental fgf3 expression in the zebrafish hindbrain, enabling the correct pattern of Fgf signalling at later stages when Fgf20 organizes neurogenesis.

Summary: A chicken model, termed gSAMURAI, has been developed that can be used as the surrogate for PGC-mediated gene editing, producing a high-grade germline chimera by inducible ablation of host germ cells.