Issues
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Cover image
Cover Image
Cover: A stage 38 Xenopus tadpole before multiciliated cell extrusion. The tadpole is transgenic for a multiciliated cell specific marker, TgTub-MemRFP (magenta), and is stained for the cilia marker acetylated tubulin (white) and the actin marker phalloidin (purple). By stage 48, all the multiciliated cells (magenta/white) will have undergone cell extrusion. See Research article by Rosa Ventrella et al. (dev201612).
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RESEARCH HIGHLIGHTS
DEVELOPMENTAL TWISTS
PERSPECTIVE
INTERVIEWS
REVIEW
The developmental dynamics of the human male germline
Summary: An overview of cellular and epigenetic dynamics of human male germline development from germline specification to spermatogenesis, highlighting the conserved and divergent features between mice and humans.
STEM CELLS AND REGENERATION
Gastruloid-derived primordial germ cell-like cells develop dynamically within integrated tissues
Highlighted Article: Mouse gastruloids, 3D in vitro models of gastrulation, contain a population of primordial germ cell (PGC)-like cells that resemble early PGCs in vivo and are closely associated with neighbouring tissues during their development.
RESEARCH ARTICLES
DNA damage signals from somatic uterine tissue arrest oogenesis through activated DAF-16
Highlighted Article: Activated DAF-16, a FOXO transcription factor working downstream of the conserved insulin signaling pathway, senses DNA damage signals from the uterus to arrest oogenesis, thereby ensuring progeny fitness.
Chondroitin sulfate is required for follicle epithelial integrity and organ shape maintenance in Drosophila
Summary: Chondroitin sulfate depletion results in muscle dysfunction and disrupted mechanical properties of the basement membrane, leading to age-dependent morphological defects in Drosophila.
Region-specific reversal of epidermal planar polarity in the rosette fancy mouse
Highlighted Article: Region-specific rotation of the planar cell polarity axis correlates with reversed hair follicle orientation in the rosette fancy mouse.
Global SUMOylation in mouse oocytes maintains oocyte identity and regulates chromatin remodeling and transcriptional silencing at the end of folliculogenesis
Summary: Using an oocyte-specific knockout, we demonstrate that UBE2I is required for timing key hallmarks of oocyte development, including chromatin organization, transcriptional regulation, meiotic progression and maintenance of fully-grown cell identity.
Dynamics of an incoherent feedforward loop drive ERK-dependent pattern formation in the early Drosophila embryo
Highlighted Article: Optogenetic dissection of the incoherent feedforward loop regulating brachyenteron in the Drosophila embryo reveals that temporal dynamics and spatial diffusion contribute to stripe formation.
Bidirectional multiciliated cell extrusion is controlled by Notch-driven basal extrusion and Piezo1-driven apical extrusion
Summary: Notch-driven basal extrusion and Piezo1-mediated apical extrusion work in concert to ensure that all multiciliated cells are lost from the epithelium by stage 48 of Xenopus embryonic development.
Induction of kidney-related gene programs through co-option of SALL1 in mole ovotestes
Highlighted Article: Using transgenic mice that overexpress Sall1 in ovaries, we demonstrate the capacity of this factor to activate kidney-related gene programs that are also observed during mole ovotestis formation.
Early-onset tufting enteropathy in HAI-2-deficient mice is independent of matriptase-mediated cleavage of EpCAM
Highlighted Article: Cleavage-resistant EpCAM does not prevent intestinal failure in the Spint2-deficient mouse model of congenital tufting enteropathy, challenging the current model of proteolysis-driven disease progression.
The Company of Biologists Workshops

For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues

Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 30 May 2025.
Meet our 2025 Pathway to Independence (PI) fellows

We are delighted to announce our third cohort of PI fellows - researchers whom we will be supporting as they transition from postdoc to Principal Investigator. Read about the eight talented fellows chosen, whom we're excited to be working with as they navigate the job market.
A case for broadening our view of mechanism in developmental biology

In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
the Node: Have your say

Our community site, the Node, is conducting a user survey about the content and the design of the site. Help us shape the Node's future and thank you for being a part of the Node over the last 15 years.