Summary: An overview of cellular and epigenetic dynamics of human male germline development from germline specification to spermatogenesis, highlighting the conserved and divergent features between mice and humans.
STEM CELLS AND REGENERATION
Highlighted Article: Mouse gastruloids, 3D in vitro models of gastrulation, contain a population of primordial germ cell (PGC)-like cells that resemble early PGCs in vivo and are closely associated with neighbouring tissues during their development.
Highlighted Article: Activated DAF-16, a FOXO transcription factor working downstream of the conserved insulin signaling pathway, senses DNA damage signals from the uterus to arrest oogenesis, thereby ensuring progeny fitness.
Chondroitin sulfate is required for follicle epithelial integrity and organ shape maintenance in Drosophila
Summary: Chondroitin sulfate depletion results in muscle dysfunction and disrupted mechanical properties of the basement membrane, leading to age-dependent morphological defects in Drosophila.
Highlighted Article: Region-specific rotation of the planar cell polarity axis correlates with reversed hair follicle orientation in the rosette fancy mouse.
Global SUMOylation in mouse oocytes maintains oocyte identity and regulates chromatin remodeling and transcriptional silencing at the end of folliculogenesis
Summary: Using an oocyte-specific knockout, we demonstrate that UBE2I is required for timing key hallmarks of oocyte development, including chromatin organization, transcriptional regulation, meiotic progression and maintenance of fully-grown cell identity.
Dynamics of an incoherent feedforward loop drive ERK-dependent pattern formation in the early Drosophila embryo
Highlighted Article: Optogenetic dissection of the incoherent feedforward loop regulating brachyenteron in the Drosophila embryo reveals that temporal dynamics and spatial diffusion contribute to stripe formation.
Bidirectional multiciliated cell extrusion is controlled by Notch-driven basal extrusion and Piezo1-driven apical extrusion
Summary: Notch-driven basal extrusion and Piezo1-mediated apical extrusion work in concert to ensure that all multiciliated cells are lost from the epithelium by stage 48 of Xenopus embryonic development.
Highlighted Article: Using transgenic mice that overexpress Sall1 in ovaries, we demonstrate the capacity of this factor to activate kidney-related gene programs that are also observed during mole ovotestis formation.
Early-onset tufting enteropathy in HAI-2-deficient mice is independent of matriptase-mediated cleavage of EpCAM
Highlighted Article: Cleavage-resistant EpCAM does not prevent intestinal failure in the Spint2-deficient mouse model of congenital tufting enteropathy, challenging the current model of proteolysis-driven disease progression.