Issues
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Cover image
Cover Image
Cover: A stage 38 Xenopus tadpole before multiciliated cell extrusion. The tadpole is transgenic for a multiciliated cell specific marker, TgTub-MemRFP (magenta), and is stained for the cilia marker acetylated tubulin (white) and the actin marker phalloidin (purple). By stage 48, all the multiciliated cells (magenta/white) will have undergone cell extrusion. See Research article by Rosa Ventrella et al. (dev201612).
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RESEARCH HIGHLIGHTS
DEVELOPMENTAL TWISTS
PERSPECTIVE
INTERVIEWS
REVIEW
The developmental dynamics of the human male germline
Summary: An overview of cellular and epigenetic dynamics of human male germline development from germline specification to spermatogenesis, highlighting the conserved and divergent features between mice and humans.
STEM CELLS AND REGENERATION
Gastruloid-derived primordial germ cell-like cells develop dynamically within integrated tissues
Highlighted Article: Mouse gastruloids, 3D in vitro models of gastrulation, contain a population of primordial germ cell (PGC)-like cells that resemble early PGCs in vivo and are closely associated with neighbouring tissues during their development.
RESEARCH ARTICLES
DNA damage signals from somatic uterine tissue arrest oogenesis through activated DAF-16
Highlighted Article: Activated DAF-16, a FOXO transcription factor working downstream of the conserved insulin signaling pathway, senses DNA damage signals from the uterus to arrest oogenesis, thereby ensuring progeny fitness.
Chondroitin sulfate is required for follicle epithelial integrity and organ shape maintenance in Drosophila
Summary: Chondroitin sulfate depletion results in muscle dysfunction and disrupted mechanical properties of the basement membrane, leading to age-dependent morphological defects in Drosophila.
Region-specific reversal of epidermal planar polarity in the rosette fancy mouse
Highlighted Article: Region-specific rotation of the planar cell polarity axis correlates with reversed hair follicle orientation in the rosette fancy mouse.
Global SUMOylation in mouse oocytes maintains oocyte identity and regulates chromatin remodeling and transcriptional silencing at the end of folliculogenesis
Summary: Using an oocyte-specific knockout, we demonstrate that UBE2I is required for timing key hallmarks of oocyte development, including chromatin organization, transcriptional regulation, meiotic progression and maintenance of fully-grown cell identity.
Dynamics of an incoherent feedforward loop drive ERK-dependent pattern formation in the early Drosophila embryo
Highlighted Article: Optogenetic dissection of the incoherent feedforward loop regulating brachyenteron in the Drosophila embryo reveals that temporal dynamics and spatial diffusion contribute to stripe formation.
Bidirectional multiciliated cell extrusion is controlled by Notch-driven basal extrusion and Piezo1-driven apical extrusion
Summary: Notch-driven basal extrusion and Piezo1-mediated apical extrusion work in concert to ensure that all multiciliated cells are lost from the epithelium by stage 48 of Xenopus embryonic development.
Induction of kidney-related gene programs through co-option of SALL1 in mole ovotestes
Highlighted Article: Using transgenic mice that overexpress Sall1 in ovaries, we demonstrate the capacity of this factor to activate kidney-related gene programs that are also observed during mole ovotestis formation.
Early-onset tufting enteropathy in HAI-2-deficient mice is independent of matriptase-mediated cleavage of EpCAM
Highlighted Article: Cleavage-resistant EpCAM does not prevent intestinal failure in the Spint2-deficient mouse model of congenital tufting enteropathy, challenging the current model of proteolysis-driven disease progression.
Development presents... live stream of our upcoming Journal Meeting
Watch a session from Development’s next Journal Meeting, Unconventional and Emerging Experimental Organisms in Cell and Developmental Biology live on the Node on Monday 18 September at 16:00 BST (15:00 UTC).
Navigating a research career with a disability
Our two recent Perspectives articles explore the lived experiences of disabled scientists in our community. Kelsey L. Anbuhl and colleagues describe the lived experiences of five biologists who share the challenges and successes of undertaking a scientific career with a disability. Whereas Jack Darius Morgan reviews the literature exploring disabled scientists’ experiences in academia.
Focus on regeneration
Tissue regeneration is a fascinating phenomenon, but the cellular and molecular mechanisms underlying regeneration remain incompletely understood. Here, Development has collated a series of articles showcasing some of the most recent advances in regenerative biology.
Keeping up with the Node: Lab meetings
Keep up with the Node 'Lab meeting' posts as the platform regularly highlights development and stem cell biology labs from across the globe and showcases research and researchers from the community. August featured the Nichols lab at the University of Edinburgh, read their 'Lab meeting' article here.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
