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Summary: An overview of cellular and epigenetic dynamics of human male germline development from germline specification to spermatogenesis, highlighting the conserved and divergent features between mice and humans.


Highlighted Article: Mouse gastruloids, 3D in vitro models of gastrulation, contain a population of primordial germ cell (PGC)-like cells that resemble early PGCs in vivo and are closely associated with neighbouring tissues during their development.


Highlighted Article: Activated DAF-16, a FOXO transcription factor working downstream of the conserved insulin signaling pathway, senses DNA damage signals from the uterus to arrest oogenesis, thereby ensuring progeny fitness.

Summary: Chondroitin sulfate depletion results in muscle dysfunction and disrupted mechanical properties of the basement membrane, leading to age-dependent morphological defects in Drosophila.

Highlighted Article: Region-specific rotation of the planar cell polarity axis correlates with reversed hair follicle orientation in the rosette fancy mouse.

Summary: Using an oocyte-specific knockout, we demonstrate that UBE2I is required for timing key hallmarks of oocyte development, including chromatin organization, transcriptional regulation, meiotic progression and maintenance of fully-grown cell identity.

Highlighted Article: Optogenetic dissection of the incoherent feedforward loop regulating brachyenteron in the Drosophila embryo reveals that temporal dynamics and spatial diffusion contribute to stripe formation.

Summary: Notch-driven basal extrusion and Piezo1-mediated apical extrusion work in concert to ensure that all multiciliated cells are lost from the epithelium by stage 48 of Xenopus embryonic development.

Highlighted Article: Using transgenic mice that overexpress Sall1 in ovaries, we demonstrate the capacity of this factor to activate kidney-related gene programs that are also observed during mole ovotestis formation.

Highlighted Article: Cleavage-resistant EpCAM does not prevent intestinal failure in the Spint2-deficient mouse model of congenital tufting enteropathy, challenging the current model of proteolysis-driven disease progression.

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