Issues

Summary: This Review examines the signalling pathways controlling vascular mural cell biology during development and regeneration and analyses their role in proper vascular function in health and disease.

Summary: The Erk and Akt signaling pathways have both common and distinct roles in the control of size, shape and patterned gene expression in an organoid model of mammalian gastrulation.

Summary: Somatic niche cells in the worm gonad relay basement membrane signals to the primordial germ cells using integrin receptors in order to control stem cell quiescence.

Summary: Neurogenesis redirects β-catenin from the adherens junctions to the nucleus to stimulate genes that control the growth and guidance of commissural axons in developing chick spinal cord.

Summary: The potassium channel gene kcnj13 regulates the shapes of all pigment cells in zebrafish stripes and its cis-regulatory evolution contributes to pattern diversification in Danio fish.

Highlighted Article: In both fly and human development, chamber-specific asymmetry in cardiomyocyte ploidy (DNA content) is conserved and reducing ploidy in flies leads to impaired cardiac function, mimicking human cardiomyopathies.

Summary: Spatial transcriptomic of embryonic control and SWI/SNF-deficient RPE uncovers RPE-specific gene regulatory networks and their dependence on the SWI/SNF complexes, which further inhibit the neural and cell proliferation genes.

Summary: The role of mechanical force in regulating gene expression at the tendon-bone interface and the consequences for the structure of the tendon matrix.

Summary: Nolz1 and its homologs are part of the evolutionarily conserved transcriptional regulator toolkits that are essential for the development of respiratory organs.

Summary: Development of the hepatic artery is controlled by Slit/Robo signalling, and perturbed morphogenesis of this artery impacts liver regeneration.

Summary: Identification of an endocytic recycling pathway that permits the rapid re-utilization of membrane for the formation of pseudocleavage furrows in the early Drosophila embryo.

Summary: This resource of single cell gene expression profiles during embryonic fly heart development expands research opportunities and translation to other species when using Drosophila to study heart development and disease.