Skip to Main Content

Advertisement

Skip Nav Destination

Issues

RESEARCH HIGHLIGHTS

PERSPECTIVE

INTERVIEWS

REVIEW

Summary: Untangling the drivers of human cardiomyocyte proliferation can stimulate cardiac regenerative approaches. This Review compares in vivo heart growth pathways with the molecular targets promoting in vitro cardiomyocyte proliferation.

STEM CELLS AND REGENERATION

Summary: Analyses of RNA- and ATAC-sequencing measurements of optic-vesicle organoid development robustly characterize the mammalian eye-field and generate specific hypotheses of cis-regulation of eye-field transcription factors.

Summary: regeneration factors expressed on myeloid genes induced in the regeneration bud are required for the regeneration-promoting function of macrophages in Xenopus laevis tail regeneration.

RESEARCH ARTICLES

Highlighted Article: In Arabidopsis, DELLA protein activity induces cell proliferation in ovule integuments that results in the development of larger ovules and, consequently, larger seeds.

Highlighted Article: Amino acid substitutions in a histone deacetylase demonstrate catalytic-dependent gene activation and non-enzymatic gene repression as crucial for Drosophila embryo development.

Summary: Endochondral ossification, which is a major process of longitudinal bone growth, is increased in Smad4-deficient mice by stimulating Wnt7b expression in differentiated hypertrophic chondrocytes.

Summary: Genetic fate mapping, single-cell transcriptomics, and electrophysiological recordings reveal that mouse cortical neurogliaform interneurons with distinct functional and anatomical properties develop from a spatially restricted pool of Tox2-expressing precursors in the preoptic area.

TECHNIQUES AND RESOURCES

Summary: An interactome for the conserved axon guidance receptor Frazzled with genetic and biochemical validation of key interaction partners – a valuable resource for future functional studies in both invertebrate and vertebrate systems.

Summary: Integrating single-nucleus ATAC-seq and single-cell RNA-seq data from the rat uterine-placental interface with data from human extravillous trophoblast cells identifies a conserved regulatory network governing the invasive trophoblast cell population.

CORRECTION

PREPRINT HIGHLIGHTS

Close Modal

or Create an Account

Close Modal
Close Modal