Issues

Summary: Untangling the drivers of human cardiomyocyte proliferation can stimulate cardiac regenerative approaches. This Review compares in vivo heart growth pathways with the molecular targets promoting in vitro cardiomyocyte proliferation.

Summary: Analyses of RNA- and ATAC-sequencing measurements of optic-vesicle organoid development robustly characterize the mammalian eye-field and generate specific hypotheses of cis-regulation of eye-field transcription factors.

Summary: regeneration factors expressed on myeloid genes induced in the regeneration bud are required for the regeneration-promoting function of macrophages in Xenopus laevis tail regeneration.

Highlighted Article: In Arabidopsis, DELLA protein activity induces cell proliferation in ovule integuments that results in the development of larger ovules and, consequently, larger seeds.

Highlighted Article: Amino acid substitutions in a histone deacetylase demonstrate catalytic-dependent gene activation and non-enzymatic gene repression as crucial for Drosophila embryo development.

Summary: Endochondral ossification, which is a major process of longitudinal bone growth, is increased in Smad4-deficient mice by stimulating Wnt7b expression in differentiated hypertrophic chondrocytes.

Summary: Genetic fate mapping, single-cell transcriptomics, and electrophysiological recordings reveal that mouse cortical neurogliaform interneurons with distinct functional and anatomical properties develop from a spatially restricted pool of Tox2-expressing precursors in the preoptic area.

Summary: An interactome for the conserved axon guidance receptor Frazzled with genetic and biochemical validation of key interaction partners – a valuable resource for future functional studies in both invertebrate and vertebrate systems.

Summary: Integrating single-nucleus ATAC-seq and single-cell RNA-seq data from the rat uterine-placental interface with data from human extravillous trophoblast cells identifies a conserved regulatory network governing the invasive trophoblast cell population.