Issues
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Cover image
Cover Image
Cover: Spatial organisation of the zebrafish germline cyst, a conserved cellular hub for oocyte production, segmented and rendered from serial block-face scanning electron microscopy (SBF-SEM) data (cytoplasmic membranes, transparent colours; nuclei, transparent greyscale). Two adjacent cysts are shown (top-left and bottom-right cell clusters). See Research article by Kumar and Elkouby (dev201349).
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RESEARCH HIGHLIGHTS
INTERVIEW
SPOTLIGHT
Single-cell proteomics: quantifying post-transcriptional regulation during development with mass-spectrometry
Summary: This Spotlight highlights how mass spectrometry analysis of single cells can enable protein quantification and help the identification of their roles in developmental mechanisms.
PRIMER
Modeling development using hydrogels
Summary: This Primer introduces hydrogel technologies and discusses how engineered hydrogels can advance our understanding of developmental biology.
HUMAN DEVELOPMENT
Human prostate organoid generation and the identification of prostate development drivers using inductive rodent tissues
Summary: Analysis of prostate organoids generated by co-culture of rat seminal vesicle mesenchyme with human iPSCs in vitro and RNA sequencing of rat tissue known to induce prostate development identifies candidate drivers of prostate development.
Directed differentiation of human hindbrain neuroepithelial stem cells recapitulates cerebellar granule neurogenesis
Highlighted Article: Human hindbrain neuroepithelial stem cells differentiated in vitro to cerebellar granule neurons (CGN) recapitulate key human-specific progenitor states, establishing a new system for developmental and disease modeling purposes.
RESEARCH ARTICLES
Kinesin-1 promotes centrosome clustering and nuclear migration in the Drosophila oocyte
Highlighted Article: This study identifies a crucial role of Kinesin-1 in centrosome clustering required for nuclear positioning and migration in the Drosophila oocyte.
DNA methylation dynamic in male rat germ cells during gametogenesis
Summary: Using FACS and DNA methyl-seq capture approaches, a detailed timing and mapping of DNA methylation was generated at key developmental stages of spermatogenesis in rat.
A chromatin remodelling SWI/SNF subunit, Snr1, regulates neural stem cell determination and differentiation
Summary: The chromatin remodelling SWI/SNF subunit Snr1 acts as a regulator of expression of transcription factors that direct cell differentiation in the developing brain.
Molecular mechanism of synovial joint site specification and induction in developing vertebrate limbs
Summary: Positioning of synovial joints is a crucial factor that governs limb architecture and functionality. RA-FGF signaling gradients define the expression domain of Barx1, which, in turn, induces the first joint site.
TECHNIQUES AND RESOURCES
DeXtrusion: automatic recognition of epithelial cell extrusion through machine learning in vivo
Summary: A new and fully available method based on machine learning can detect automatically cellular events (including cell extrusion, cell division and cell differentiation) from fluorescent movies of epithelia in vivo.
Tools to analyze the organization and formation of the germline cyst in zebrafish oogenesis
Summary: A description of a set of imaging-based tools for automated 3D analyses and functional live manipulations in vivo of the germline cyst, a cellular hub for oocyte production, in the zebrafish ovary.
Development presents... live stream of our upcoming Journal Meeting

Watch a session from Development’s next Journal Meeting, Unconventional and Emerging Experimental Organisms in Cell and Developmental Biology live on the Node on Monday 18 September at 16:00 BST (15:00 UTC).
Navigating a research career with a disability

Our two recent Perspectives articles explore the lived experiences of disabled scientists in our community. Kelsey L. Anbuhl and colleagues describe the lived experiences of five biologists who share the challenges and successes of undertaking a scientific career with a disability. Whereas Jack Darius Morgan reviews the literature exploring disabled scientists’ experiences in academia.
Focus on regeneration

Tissue regeneration is a fascinating phenomenon, but the cellular and molecular mechanisms underlying regeneration remain incompletely understood. Here, Development has collated a series of articles showcasing some of the most recent advances in regenerative biology.
Keeping up with the Node: Lab meetings

Keep up with the Node 'Lab meeting' posts as the platform regularly highlights development and stem cell biology labs from across the globe and showcases research and researchers from the community. August featured the Nichols lab at the University of Edinburgh, read their 'Lab meeting' article here.
Read & Publish Open Access publishing: what authors say

We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.