Issues
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Cover image
Cover Image
Cover: Spatial organisation of the zebrafish germline cyst, a conserved cellular hub for oocyte production, segmented and rendered from serial block-face scanning electron microscopy (SBF-SEM) data (cytoplasmic membranes, transparent colours; nuclei, transparent greyscale). Two adjacent cysts are shown (top-left and bottom-right cell clusters). See Research article by Kumar and Elkouby (dev201349).
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RESEARCH HIGHLIGHTS
INTERVIEW
SPOTLIGHT
Single-cell proteomics: quantifying post-transcriptional regulation during development with mass-spectrometry
Summary: This Spotlight highlights how mass spectrometry analysis of single cells can enable protein quantification and help the identification of their roles in developmental mechanisms.
PRIMER
Modeling development using hydrogels
Summary: This Primer introduces hydrogel technologies and discusses how engineered hydrogels can advance our understanding of developmental biology.
HUMAN DEVELOPMENT
Human prostate organoid generation and the identification of prostate development drivers using inductive rodent tissues
Summary: Analysis of prostate organoids generated by co-culture of rat seminal vesicle mesenchyme with human iPSCs in vitro and RNA sequencing of rat tissue known to induce prostate development identifies candidate drivers of prostate development.
Directed differentiation of human hindbrain neuroepithelial stem cells recapitulates cerebellar granule neurogenesis
Highlighted Article: Human hindbrain neuroepithelial stem cells differentiated in vitro to cerebellar granule neurons (CGN) recapitulate key human-specific progenitor states, establishing a new system for developmental and disease modeling purposes.
RESEARCH ARTICLES
Kinesin-1 promotes centrosome clustering and nuclear migration in the Drosophila oocyte
Highlighted Article: This study identifies a crucial role of Kinesin-1 in centrosome clustering required for nuclear positioning and migration in the Drosophila oocyte.
DNA methylation dynamic in male rat germ cells during gametogenesis
Summary: Using FACS and DNA methyl-seq capture approaches, a detailed timing and mapping of DNA methylation was generated at key developmental stages of spermatogenesis in rat.
A chromatin remodelling SWI/SNF subunit, Snr1, regulates neural stem cell determination and differentiation
Summary: The chromatin remodelling SWI/SNF subunit Snr1 acts as a regulator of expression of transcription factors that direct cell differentiation in the developing brain.
Molecular mechanism of synovial joint site specification and induction in developing vertebrate limbs
Summary: Positioning of synovial joints is a crucial factor that governs limb architecture and functionality. RA-FGF signaling gradients define the expression domain of Barx1, which, in turn, induces the first joint site.
TECHNIQUES AND RESOURCES
DeXtrusion: automatic recognition of epithelial cell extrusion through machine learning in vivo
Summary: A new and fully available method based on machine learning can detect automatically cellular events (including cell extrusion, cell division and cell differentiation) from fluorescent movies of epithelia in vivo.
Tools to analyze the organization and formation of the germline cyst in zebrafish oogenesis
Summary: A description of a set of imaging-based tools for automated 3D analyses and functional live manipulations in vivo of the germline cyst, a cellular hub for oocyte production, in the zebrafish ovary.
Save the date - Human Development: Stem Cells, Models, Embryos

We will be hosting a 2026 Human Development: Stem Cells, Models, Embryos meeting. We have teamed up with the Wellcome-funded consortium, the Human Developmental Biology Initiative (HDBI) to co-organise this event, which will bring together researchers from around the world, united by an interest in understanding human developmental biology. Save the date for 7-9 September 2026 and register.
Development presents…

Development is delighted to host a webinar series showcasing the latest developmental biology and stem cell research. The webinars are held each month with talks from postdocs applying for independent positions as part of our Pathway to Independence programme. Visit Development presents... on the Node to see which stimulating topics are coming up in the next few months.
Meet our 2025 Pathway to Independence (PI) fellows

We are delighted to announce our third cohort of PI fellows - researchers whom we will be supporting as they transition from postdoc to Principal Investigator. Read about the eight talented fellows chosen, whom we're excited to be working with as they navigate the job market.
From bench to business

In this Perspective, researchers who have transitioned from academia to industry tell us how they have navigated patents, intellectual property, investors and biotechnology start-ups to bring new biological advances from the bench and into the boardroom.
Browse by subject
![Development logo - Browse by subject: Explore Development's content, now easily accessible by subject area. The ad has a black background with three vibrant scientific images: a developing embryo on the left, a green plant-like structure in the center, and a gastruloid (a circular cell with a bright pink center and blue outer ring) on the right. [Blue button: browse content].](https://cob.silverchair-cdn.com/ImageLibrary/Development/Snippets/2025_05_Dev_Browse-by-subject_600x230_Snippet.png?versionId=9135)
From cardiovascular development and regeneration to tissue engineering and organoids, Development’s browse by subject archive allows you to access the latest papers (from late 2024 onwards) on a particular field of interest. In addition to our curated subject collections, these subject pages allow readers to browse a broader range of papers organised by topic.