Issues

Summary: The latest findings on non-canonical imprinting and a discussion of what is known about the conservation of this phenomenon and how it impacts mammalian development.

Summary: This Review presents compelling examples of the roles and regulation of transcriptional bursting in development and explores the question of how stochastic transcription leads to deterministic organism development.

Highlighted Article: Longitudinal scRNA-seq analysis of human inner ear organoids identifies supporting cells as possible precursors of hair cells and upregulation of previously unrecognized early genes during hair cell differentiation.

Summary: Functional inversion of the Notch signaling pathway underlies the ability of horizontal basal cells to regulate their own differentiation into olfactory sensory neurons during injury-induced regeneration of the olfactory epithelium.

Highlighted Article: Induced overexpression of oncogenic HRAS^G12V stimulated dedifferentiation and proliferation of adult zebrafish cardiomyocytes, leading to cardiomegaly. Short reversible HRAS^G12V overexpression accelerated heart regeneration, revealing a mechanism for boosting cardiac restoration.

Summary: Physiological reduction of insulator protein levels in the germ cysts results in a short-term burst of expression of telomeric retrotransposon encoding reverse transcriptase that appears to be necessary for telomere elongation in the germline.

Summary: Previously unreported mechanism involving anillin and PRC1 to maintain myosin in the contractile ring during late furrow ingression ensures successful completion of cytokinesis.

Summary: Sim plays two roles throughout oogenesis: in stage 10B-12 follicles, it functions with Tgo to promote follicle cell maturation; in mature follicles, it actively regulates genes required for follicle rupture.

Summary: This work reveals the unrecognized role of PATL2 in regulating the maternal transcriptome coupled with EIF4E and CPEB1, and phosphorylation at S279 act as a molecular switch for PATL2 degradation.

Summary: Optimization of CRISPR-Cas9 assisted knock-in in zebrafish using PCR generated HDR templates, exemplified in vamp/synaptobrevin genes