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Issues

RESEARCH HIGHLIGHT

EDITORIAL

PERSPECTIVES

INTERVIEW

DEVELOPMENT AT A GLANCE

Summary: This Development at a Glance article provides an overview of the genomic organization, protein structure and regulation of Hox genes and our current understanding of their roles both during and after embryogenesis.

REVIEW

Summary: A Review discussing how the formation of a polarised dorsal aorta leads to the creation of a unique niche suitable for haematopoietic stem cell emergence within the floor of this vessel.

STEM CELLS AND REGENERATION

Summary: Intraventricular infusion of recombinant insulin-like growth factor 2 (IGF2) in a Cdkn1c-deficient mouse, reveals that p57 partially mediates the differentiation effects of IGF2 independently of its role in cell-cycle progression.

Summary: Ccn2a promotes intervertebral disc regeneration in aged degenerated discs in zebrafish. Thus, CCN2 could be exploited for therapeutic intervention in degenerated human discs.

RESEARCH REPORTS

Summary: Hydrozoan spH2B variants containing SPKK motifs package sperm chromatin with limited compaction yet reduce accessibility and downregulate transcription. This could contribute to sperm buoyancy as a reproductive adaptation.

Highlighted Article: Spindle assembly checkpoint (SAC) acquisition is likely specific to Phallusia mammillata embryos, whereas modulation of SAC efficiency in SAC proficient stages depends on cell fate and cell size.

RESEARCH ARTICLES

Summary: Isolation of a temperature-sensitive mutation in insulin receptor could prove to be a valuable tool for the Drosophila genetic model of insulin resistance and type 2 diabetes.

Summary: Quantitative trait loci mapping identifies two genomic loci that epistatically modulate horizontal cell number in the mouse retina, uncovering a novel interaction between Neurog2 and Isl1 in the development of these cells.

Summary: This paper shows that canonical proneural bHLH complexes do not globally affect neurogenesis in C. elegans but have selective effects in specific linages on specific neuronal features.

TECHNIQUES AND RESOURCES

Summary: Conditional induction of gene expression to disrupt MAPK signaling using the Tet-On system in sea urchin embryos demonstrates the utility of this system to investigate later stages of development in echinoderms.

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