Issues
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Cover image
Cover Image
Cover: Confocal image of a horizontal section through a wild-type adult Drosophila eye, stained for Retinol dehydrogenase B (RdhB, green), N-cadherin (red) and Rhodopsin 1 (Rh1, blue). The image shows the curved external surfaces of the corneal lenses and their attachments to the secondary and tertiary pigment cells stained for RdhB, as well as the rhabdomeres stained for Rh1 that extend through the full depth of the retina. See Research article by Wang et al. (dev200217).
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RESEARCH HIGHLIGHTS
EDITORIAL
PERSPECTIVE
INTERVIEW
REVIEW
The mechanical forces that shape our senses
Summary: This Review gives an overview of our current understanding of how physical forces influence developing sensory organs, both in the embryo and in organoid cultures.
STEM CELLS AND REGENERATION
Notch-dependent DNA cis-regulatory elements and their dose-dependent control of C. elegans stem cell self-renewal
Highlighted Article: Notch-dependent DNA cis-regulatory elements work together in their developmental context in C. elegans to shape a transcriptional gradient, control stem cell pool size, and govern differentiation onset.
Jagged 2b induces intercellular signaling within somites to establish hematopoietic stem cell fate in zebrafish
Summary: Jag2b-driven Notch signaling regulates efna1b expression in the somite to modulate the Wnt16–Dlc/Dld signaling axis, which is required for hematopoietic stem cell specification.
Regenerating vascular mural cells in zebrafish fin blood vessels are not derived from pre-existing mural cells and differentially require Pdgfrb signalling for their development
Summary: Conserved roles for Pdgfrb signalling in development and regeneration suggest a limited capacity of mural cells to self-renew or contribute to other cell types during tissue regeneration.
RhoA/ROCK signaling antagonizes bovine trophoblast stem cell self-renewal and regulates preimplantation embryo size and differentiation
Highlighted Article: Signaling for self-renewal and differentiation revealed via systems biology analysis of the bovine blastocyst trophectoderm permits establishment of trophoblast stem cells and discovery of mechanisms surrounding placental development and differentiation.
Src acts with WNT/FGFRL signaling to pattern the planarian anteroposterior axis
Highlighted Article: src-1 acts in parallel or downstream of pathways involving Wnt and FGFRL factors to regulate positional information along the anteroposterior axis in planarian regeneration
RESEARCH ARTICLES
Molecular contribution to embryonic aneuploidy and karyotypic complexity in initial cleavage divisions of mammalian development
Highlighted Article: Using a combination of live-cell imaging, single-cell sequencing and genetic manipulation, the molecular connections are defined between cell cycle checkpoints, mitotic divisions and aneuploidy in mammalian preimplantation embryos.
Premeiotic endoreplication is essential for obligate parthenogenesis in geckos
Summary: Premeiotic endoreplication is a mechanism of production of unreduced eggs in parthenogenetic gecko complexes. The endoreplication might be induced by a failure of oocytes with the original ploidy during pachytene in the obligate parthenogenetic hybrids.
FOXP4 differentially controls cold-induced beige adipocyte differentiation and thermogenesis
Summary: Foxp4 has a phase-dependent role in beige adipocyte differentiation, priming their early cell fate commitment but attenuating their thermogenic activation at mature stages.
A 3D molecular map of the cavefish neural plate illuminates eye-field organization and its borders in vertebrates
Summary: At the end of gastrulation, the vertebrate eye field is already highly regionalized, and species-specific or morphotype-specific pattern variations are apparent.
FOXO1 represses sprouty 2 and sprouty 4 expression to promote arterial specification and vascular remodeling in the mouse yolk sac
Summary: A previously unreported role for FOXO1 as a key transcriptional repressor regulating both pre-flow arterial specification and subsequent vessel remodeling within the murine yolk sac.
The Blimp-1 transcription factor acts in non-neuronal cells to regulate terminal differentiation of the Drosophila eye
Summary: Terminal differentiation of the Drosophila eye requires Blimp-1, a transcription factor induced by ecdysone signaling, that promotes photoreceptor rhabdomere extension and increases corneal lens refractive power.
Traip controls mushroom body size by suppressing mitotic defects
Summary: Analysis of the effect on brain development of mutations in the Drosophila traip gene reveals that Traip suppresses DNA bridges and premature neural stem cell loss to ensure proper brain size.
SCARECROW is deployed in distinct contexts during rice and maize leaf development
Summary: The transcription factor SCARECROW patterns stomata in rice leaves, whereas in maize it predominantly patterns the inner leaf.
TECHNIQUES AND RESOURCES
Establishment and characterization of equine mammary organoids using a method translatable to other non-traditional model species
Summary: A protocol to establish mammary organoids from non-traditional model species, providing a physiologically relevant 3D in vitro model for comparative studies centered on mammary gland development and cancer.
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
