Issues
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Cover image
Cover Image
Cover: Confocal image of the flank of a live intubated adult transgenic zebrafish with scales shown in white (BODIPY 630/650), lymphatic vessels in orange [Tg(mrc1a:eGFP)y251] and blood vessels in blue [Tg(kdrl:mcherry)y206]. See research article by Castranova et al. (dev199667).
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RESEARCH HIGHLIGHTS
DEVELOPMENTAL TWISTS
INTERVIEWS
SPOTLIGHT
Reprogramming cellular identity in vivo
Summary: In vivo lineage reprogramming emerges as innovative strategy for organ repair. Using conversion of brain glia into induced neurons as an example, this Spotlight highlights conceptual advances and technical challenges.
STEM CELLS AND REGENERATION
Heterogeneous pdgfrb+ cells regulate coronary vessel development and revascularization during heart regeneration
Summary: Heterogeneous pdgfrb+ epicardium-derived cells and coronary mural cells are essential for coronary vessel development and zebrafish heart regeneration.
Notch signaling regulates neural stem cell quiescence entry and exit in Drosophila
Summary: Notch signaling promotes neuroblast quiescence in Drosophila. Notch activity becomes attenuated in quiescent neuroblasts and low to no active Notch is required for neuroblast reactivation in response to dietary nutrients.
Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration
Highlighted Article: A resource of tissue regeneration enhancer elements (TREEs) of epicardial cells during zebrafish heart regeneration reveals new concepts in TREE-based gene regulation.
Intermittent ERK oscillations downstream of FGF in mouse embryonic stem cells
Summary: High time-resolution measurements reveal previously unseen signaling dynamics in single pluripotent cells, which alternate between oscillatory and non-oscillatory ERK activity. ERK dynamics change with ligand concentration, cell cycle and differentiation state.
RESEARCH REPORT
Nuclear morphogenesis: forming a heterogeneous nucleus during embryogenesis
Highlighted Article: The nuclear space becomes progressively heterogeneous during embryo development, forming distinct transcriptional sub-nuclear environments, paralleling the partitioning of the embryo body during morphogenesis.
RESEARCH ARTICLES
PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation
Summary: The closely related Prdm paralogs Prdm3 and Prdm16 act antagonistically of each other to control chromatin accessibility and balance downstream gene expression in chondrocytes during vertebrate craniofacial cartilage development.
Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum
Highlighted Article: Expression of Meis2, which promotes striatal MSN fate determination, is dependent on Dlx1/2 in the lateral ganglionic eminence, and this regulation is at least partially mediated by the hs599 enhancer.
Dual role of Ovol2 on the germ cell lineage segregation during gastrulation in mouse embryogenesis
Highlighted Article: Ovol2 and Zeb1 determine the balance between PGCs and somatic cells.
Notch signaling is a novel regulator of visceral smooth muscle cell differentiation in the murine ureter
Summary: Notch signaling is required for precise temporal activation of myocardin and, independently, of a group of genes expressed later in the visceral smooth muscle cell differentiation program of the murine ureter.
Quantitative live imaging of floral organ initiation and floral meristem termination in Aquilegia
Highlighted Article: Quantitative live-imaging of Aquilegia floral meristems reveals distinct patterns of floral organ initiation and cell-level dynamics of floral meristem termination.
A unique miR775-GALT9 module regulates leaf senescence in Arabidopsis during post-submergence recovery by modulating ethylene and the abscisic acid pathway
Summary: miR775 is unique in origin and it regulates post-submergence recovery by negatively regulating the target GALT9 and modulating senescence-associated genes, ethylene and ABA pathway components in Arabidopsis.
TECHNIQUES AND RESOURCES
Live 3D imaging and mapping of shear stresses within tissues using incompressible elastic beads
Highlighted Article: A pipeline of techniques, based on incompressible elastic sensors, to map in 3D and in real time the local shear stresses in living tissues, and to investigate the role of mechanical constraints during morphogenesis and development.
Long-term imaging of living adult zebrafish
Summary: A new method for intubation and long-term imaging of living adult zebrafish and other aquatic species on inverted microscopes.
Multi-view confocal microscopy enables multiple organ and whole organism live-imaging
Highlighted Article: MuViScopy is a multi-angle and multi-scale fluorescence confocal microscopy methodology enabling live-imaging of multiple organs with cellular resolution without sample embedding.
CORRECTION
The Company of Biologists Workshops
For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 30 May 2025.
Meet our 2025 Pathway to Independence (PI) fellows
We are delighted to announce our third cohort of PI fellows - researchers whom we will be supporting as they transition from postdoc to Principal Investigator. Read about the eight talented fellows chosen, whom we're excited to be working with as they navigate the job market.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
the Node: Have your say
Our community site, the Node, is conducting a user survey about the content and the design of the site. Help us shape the Node's future and thank you for being a part of the Node over the last 15 years.
