Issues
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Cover image
Cover Image
Cover: Sagittal section of an 8 day post-fertilisation zebrafish eye with the outer photoreceptor segments stained by anti-Zpr1 (magenta), amacrine and retinal ganglion cells expressing GFP [Tg(islt1:GFP); cyan], and nuclei counterstained with DAPI (blue). See Research article by Hernández-Bejarano et al. (dev200938).
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RESEARCH HIGHLIGHTS
DEVELOPMENTAL TWISTS
PERSPECTIVE
INTERVIEWS
SPOTLIGHT
The present and future of Turing models in developmental biology
Summary: This Spotlight discusses how the Turing model, first published 70 years ago, has been implemented and adapted to understand developmental principles.
REVIEW
Mammalian DNA methylome dynamics: mechanisms, functions and new frontiers
Summary: This Review examines the mechanisms and functions of regulated DNA methylation and demethylation, highlighting how these dynamics contribute to mammalian development and tissue maturation.
STEM CELLS AND REGENERATION
Suppression of YAP safeguards human naïve pluripotency
Highlighted Article: Tankyrase inhibition suppresses trophectoderm induction to stabilise human naïve pluripotent stem cells. This effect is mediated by stabilising angiomotin to restrict YAP activity.
RESEARCH REPORTS
Selective refinement of glutamate and GABA synapses on dorsal raphe 5-HT neurons during postnatal life
Highlighted Article: A combination of high-resolution immunofluorescence, electrophysiology and Fos immunohistochemistry uncovers a postnatal period of selective synaptic refinement of glutamate and GABA inputs to raphe 5-HT neurons.
OsFLZ2 interacts with OsMADS51 to fine-tune rice flowering time
Summary: OsFLZ2 interacts with OsMADS51 and inhibits the transcriptional activation activity of OsMADS51 in modulating the expression of its target gene Early heading date 1, thus delaying flowering in rice.
RESEARCH ARTICLES
Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development
Highlighted Article: The UBE4B-KLHL22 E3 cascade tightly controls activation of mTOR signaling and sustains perinatal neurogenesis at an appropriate level during mouse brain development.
Translational control by maternal Nanog promotes oogenesis and early embryonic development
Highlighted Article: Zebrafish Nanog regulates oogenesis and early embryogenesis through translational control of maternal mRNA via a mechanism whereby Nanog acts as a transcriptional repressor to suppress transcription of eef1a1l2.
Surface-localized glycoproteins act through class C ARFs to fine-tune gametophore initiation in Physcomitrium patens
Summary: Cell surface-localized arabinogalactan proteins control the expression strength of transcription factors to regulate cell wall-modifying enzymes, thereby fine-tuning the timing of gametophore initiation in moss.
Foxd1-dependent induction of a temporal retinal character is required for visual function
Summary: This study provides a mechanistic link between eye patterning and the establishment of functionally distinct retinal regions, and reveals that the temporal retina preferentially controls specific aspects of visual function.
blf and the drl cluster synergistically regulate cell fate commitment during zebrafish primitive hematopoiesis
Summary: blf and drl cluster genes act as determinants in the fate commitment of progenitor cells during primitive hematopoiesis by constraining the expression of vasculogenesis-promoting and monocytopoiesis-promoting genes.
A metazoan-specific C-terminal motif in EXC-4 and Gα-Rho/Rac signaling regulate cell outgrowth during tubulogenesis in C. elegans
Summary: A highly conserved C-terminal cysteine in EXC-4/CLIC and the Gα-Rho/Rac pathway regulate outgrowth of the C. elegans excretory canal cell, linking a metazoan-specific motif in CLICs to the emerging function of these proteins in Rho/Rac signaling.
CORRECTION
The Company of Biologists Workshops
For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 30 May 2025.
Meet our 2025 Pathway to Independence (PI) fellows
We are delighted to announce our third cohort of PI fellows - researchers whom we will be supporting as they transition from postdoc to Principal Investigator. Read about the eight talented fellows chosen, whom we're excited to be working with as they navigate the job market.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. Together with our preprint highlights service, preLights, these perspectives help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
the Node: Have your say
Our community site, the Node, is conducting a user survey about the content and the design of the site. Help us shape the Node's future and thank you for being a part of the Node over the last 15 years.
