Issues

Summary: This Spotlight explores recent findings from Drosophila and vertebrates on how mitochondrial respiration and morphology interact with neural stem cell transitions in the developing and adult brain in vivo.

Summary: A review of how diverse groups of dermal fibroblasts regulate epidermal and hair follicle growth and differentiation, fueled by tools capable of resolving molecular heterogeneity at the single-cell level.

Summary: A unique transcriptional profile of the developing human fetal VM and functionally mature human DA neurons that can be used to guide stem cell-based therapies and disease modeling approaches in Parkinson's disease.

Summary: A combination of computational modeling and experiments examining the spatial distribution of Ptc and CiA reveals distinct signaling profiles downstream of Hh in different organs during Drosophila development.

Summary: SynbCre is a new and efficient transgenic Cre line in the mouse placenta that enables functional validation of the essential role of ferroportin in placental iron transport.

Summary: Nr2f nuclear receptors broadly activate skeletal progenitor genes in post-migratory cranial neural crest cells.

Highlighted Article: In vivo RNA interference identifies the receptor tyrosine kinase discoidin domain receptor as required for the proper development and function of non-myelinating glia and axonal ensheathment in the fly.

Highlighted Article: Loss of the Maf family transcription factors MAFB and c-MAF or the transcriptional repressor BLIMP1 leads to an inability of neonatal enterocytes to take up nutrients.

Highlighted Article: Focal adhesions drive actin rearrangements that are essential for endothelial cell elongation and junction linearisation in flow-pressured vessels.

Summary: Different lateral organs with different morphology possess different properties of meristems; cell division angles, position of cell proliferative area and AN3 localization patterns. This study examined their roles using simulation analyses.

Summary: Genetic ablation of either cxcr4a or the ligand gene cxcl12b causes pharyngeal arch artery (PAA) stenosis in zebrafish, revealing a central role for chemokine signaling in PAA vasculogenesis through orchestrating angioblast proliferation and differentiation.

Summary: Differences in regulatory interactions between Ubx and the eyespot-essential genes Dll, sal and Antp explain the development of different numbers of eyespots in fore- and hindwings of Bicyclus anynana butterflies.

Highlighted Article: Loss of Wnt4 in the gubernaculum leads to aberrant left unilateral testicular descent and fertility defects despite the normal descent of the right testis.

Summary: N-WASP-Arp2/3 signaling is essential to the establishment of the stem dendrite, as well as the expansion of dendritic tree, in developing Purkinje cells in vivo.

Summary: Gene regulation is governed by protein complexes composed of DNA-binding transcription factors and non-DNA-binding co-factors. CUT&RUN-LoV-U facilitates the detection of the genome-wide binding profile of co-factors.