Skip to Main Content

Advertisement

Skip Nav Destination

Issues

RESEARCH HIGHLIGHTS

EDITORIAL

PERSPECTIVE

INTERVIEW

SPOTLIGHT

Summary: This Spotlight explores recent findings from Drosophila and vertebrates on how mitochondrial respiration and morphology interact with neural stem cell transitions in the developing and adult brain in vivo.

REVIEW

Summary: A review of how diverse groups of dermal fibroblasts regulate epidermal and hair follicle growth and differentiation, fueled by tools capable of resolving molecular heterogeneity at the single-cell level.

HUMAN DEVELOPMENT

Summary: A unique transcriptional profile of the developing human fetal VM and functionally mature human DA neurons that can be used to guide stem cell-based therapies and disease modeling approaches in Parkinson's disease.

RESEARCH REPORTS

Summary: A combination of computational modeling and experiments examining the spatial distribution of Ptc and CiA reveals distinct signaling profiles downstream of Hh in different organs during Drosophila development.

Summary: SynbCre is a new and efficient transgenic Cre line in the mouse placenta that enables functional validation of the essential role of ferroportin in placental iron transport.

Summary: Nr2f nuclear receptors broadly activate skeletal progenitor genes in post-migratory cranial neural crest cells.

RESEARCH ARTICLES

Highlighted Article: In vivo RNA interference identifies the receptor tyrosine kinase discoidin domain receptor as required for the proper development and function of non-myelinating glia and axonal ensheathment in the fly.

Highlighted Article: Loss of the Maf family transcription factors MAFB and c-MAF or the transcriptional repressor BLIMP1 leads to an inability of neonatal enterocytes to take up nutrients.

Highlighted Article: Focal adhesions drive actin rearrangements that are essential for endothelial cell elongation and junction linearisation in flow-pressured vessels.

Summary: Different lateral organs with different morphology possess different properties of meristems; cell division angles, position of cell proliferative area and AN3 localization patterns. This study examined their roles using simulation analyses.

Summary: Genetic ablation of either cxcr4a or the ligand gene cxcl12b causes pharyngeal arch artery (PAA) stenosis in zebrafish, revealing a central role for chemokine signaling in PAA vasculogenesis through orchestrating angioblast proliferation and differentiation.

Summary: Differences in regulatory interactions between Ubx and the eyespot-essential genes Dll, sal and Antp explain the development of different numbers of eyespots in fore- and hindwings of Bicyclus anynana butterflies.

Highlighted Article: Loss of Wnt4 in the gubernaculum leads to aberrant left unilateral testicular descent and fertility defects despite the normal descent of the right testis.

Summary: N-WASP-Arp2/3 signaling is essential to the establishment of the stem dendrite, as well as the expansion of dendritic tree, in developing Purkinje cells in vivo.

TECHNIQUES AND RESOURCES

Summary: Gene regulation is governed by protein complexes composed of DNA-binding transcription factors and non-DNA-binding co-factors. CUT&RUN-LoV-U facilitates the detection of the genome-wide binding profile of co-factors.

Close Modal

or Create an Account

Close Modal
Close Modal