DEVELOPMENT AT A GLANCE
Summary: This Development at a Glance article describes how a cells’ limited repertoire of behaviours provide the basis for quantifying morphogenetic phenotypes.
Summary: This Review discusses current knowledge on the regulation of the movement and positioning of nuclei in multinucleated cells, applying the principles learned from well-studied models to other systems.
STEM CELLS AND REGENERATION
Highlighted Article: The RNA decay factor, UPF2, drives developmental progression of the mouse inner cell mass, with its loss leading to a deficit of epiblast cells and peri-implantation embryo lethality.
Summary: Loss of β-catenin in the embryonic mouse hem causes profoundly defective dentate gyrus morphogenesis and Cajal-Retzius migration due to disorganization of the fimbrial glial scaffold.
A mutation in THREONINE SYNTHASE 1 uncouples proliferation and transition domains of the root apical meristem: experimental evidence and in silico proposed mechanism
Highlighted Article: Experiments and mathematical modeling suggest that to maintain the functional root apical meristem, its stem cell niche depends on threonine metabolism and modeling correctly predicts root growth pattern.
Specialized germline P-bodies are required to specify germ cell fate in Caenorhabditis elegans embryos
Highlighted Article: This paper describes a new condensate in the C. elegans germ plasm, ‘germline P-bodies’, which contain regulators of RNA translation and decay and are essential to specify germ cell fate.
High-resolution ribosome profiling reveals translational selectivity for transcripts in bovine preimplantation embryo development
Summary: High-resolution ribosome profiling of bovine oocytes and early embryos characterizes the translational landscapes of preimplantation embryo development and reveals four modes of translational selectivity for transcripts in oocytes and embryos.
Shadow enhancers modulate distinct transcriptional parameters that differentially effect downstream patterning events
Highlighted Article: Non-intuitive shadow enhancer synergies are revealed by measuring transcriptional kinetics at the endogenous short gastrulation locus, giving rise to distinct patterning consequences in the dorsal ectoderm of Drosophila embryos.
Sex-biased effects on hippocampal circuit development by perinatal SERT expression in CA3 pyramidal neurons
Highlighted Article: Perinatal SERT expression in hippocampal and medial prefrontal cortex modulates sexually dimorphic gene expression during hippocampal circuit assembly and is a source of sex-biased susceptibilities to cognitive and behavioral impairments.
EGFR signal transduction is downregulated in C. elegans vulval precursor cells during dauer diapause
Summary: EGFR-Ras-ERK activity is downregulated during dauer diapause, a reversible long-lived stage of developmental quiescence, by a mechanism that desensitizes multipotential cells to an EGF patterning signal.
In toto imaging of early enteric nervous system development reveals that gut colonization is tied to proliferation downstream of Ret
Summary: Early development of the enteric nervous system is orchestrated by neural progenitor cells that migrate into the nascent gut and proliferate extensively in a Ret-dependent manner, driving their colonization from the foregut to the hindgut.
Different temporal requirements for tartan and wingless in the formation of contractile interfaces at compartmental boundaries
Summary: An unbiased screen to identify cell surface receptors at a Drosophila model boundary reveals that actomyosin enrichment at parasegmental boundaries requires Tartan during early germband extension but Wingless signalling at later stages.
Highlighted Article: The condensation of nephron progenitor cells (NPCs) to the ureteric bud depends strongly on the strong chemokinetic effects of FGF8, providing a mechanism through which NPCs can adapt to the microenvironment.
Summary: Analysis of a Cxcl12 transgenic reporter mouse reveals distinct gene enrichment that defines functional and spatially unique endothelial subtypes in the developing pulmonary arterial tree.
The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis
Summary: The Foxf1/Foxf2 transcription factors activate the HGF and TGFβ signaling pathways downstream of hedgehog signaling to drive sequential steps in tongue organogenesis and tongue muscle organization.
Highlighted Article: A subset of gustatory receptor-expressing internal sensory neurons in Drosophila innervates insulin-producing cells and regulates larval development in a stage-specific manner.
Summary: Loss of PAR3 in mouse telencephalon reveals that PAR3 regulates the transition to neurogenic divisions at early neurogenesis by restricting hedgehog signaling and establishing ciliary integrity.
Summary: The transcription factor Isl1 regulates Cxcl12+ mesenchymal cell migration through the SHH/WNT5A cascade, and CXCL12 serves as a bidirectional cue for myoblasts expressing its receptor CXCR4 in a concentration-dependent manner.
The miR156 juvenility factor and PLETHORA 2 form a regulatory network and influence timing of meristem growth and lateral root emergence
Summary: Examination of root development in Arabidopsis thaliana mutants reveals a gene regulatory network involving mutual repression of miR156 and PLT2 that influences a phase-change transition in roots.
Highlighted Article: Specification of the gut progenitor E in a distant relative of Caenorhabditis elegans uses the GATA factor ELT-3, suggesting that the ancestral network was simpler.
Summary: Zar1l acts as translational repressor by acting on the 3′UTR of cMos mRNA in Xenopus oocytes, ensuring temporally regulated translation of this key cell cycle regulator during oocyte maturation.
Summary: Plexin D1 acts cell-autonomously in LECs to guide the pathfinding of the zebrafish facial and trunk lymphatic networks.
Summary: Seedling vigor is a key trait that determines juvenile plant performance and can be enhanced by heterologous expression of structural variants of BRX family proteins from the lycophyte Selaginella moellendorffii.
Admp regulates tail bending by controlling ventral epidermal cell polarity via phosphorylated myosin localization in Ciona
Summary: Admp is an upstream regulator of tail bending in the chordate Ciona tailbud embryo, determining tissue polarity of the ventral midline epidermis by localizing phosphorylated myosin.
Summary: Single-nuclei analysis identified regulatory genes of cell differentiation in poplar apex, establishing a comparison between a model annual herbaceous and a woody perennial plant species.
TECHNIQUES AND RESOURCES
DeepProjection: specific and robust projection of curved 2D tissue sheets from 3D microscopy using deep learning
Summary: DeepProjection is a deep learning based tool for robust and rapid 2D projection enabling quantification of complex epithelial tissue morphologies with low signal-to-noise ratio and strongly fluorescent artifacts.