Issues
Special Issue: Modelling Development in vitro
HUMAN DEVELOPMENT
Imaging three-dimensional brain organoid architecture from meso- to nanoscale across development
Summary: The combination of light-sheet fluorescence and expansion microscopy enables imaging of mature human brain organoids in toto and down to synaptic resolution.
Practical guide for preparation, computational reconstruction and analysis of 3D human neuronal networks in control and ischaemic conditions
Summary: An optimized protocol is presented that allows morphological, quantifiable differences between the damaged and control human neuronal networks to be detected in three-dimensional cultures.
Human neural progenitors establish a diffusion barrier in the endoplasmic reticulum membrane during cell division
Summary: Asymmetric segregation of cellular components, which may contribute to the fate and behavior of human neural progenitors, is allowed by a diffusion barrier in the endoplasmic reticulum membrane during cell division.
Mechanisms underlying WNT-mediated priming of human embryonic stem cells
Summary: The key developmental transcription factor eomesodermin can replace Wnt priming in the differentiation of human embryonic stem cells into mesendoderm.
Human iPSC-derived cerebral organoids model features of Leigh syndrome and reveal abnormal corticogenesis
Summary: Induced pluripotent stem cell-derived model systems reveal defects in early neurogenesis due to dysregulation of key metabolic pathways associated with Leigh syndrome.
Generation of functional human oligodendrocytes from dermal fibroblasts by direct lineage conversion
Summary: This paper shows the generation of myelinating human oligodendrocytes from dermal fibroblasts using a direct lineage conversion technique, which could be of high interest for regenerative medicine applications.
Development Journal Meeting 2022: From Stem Cells to Human Development
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Following a virtual meeting in 2020, we are delighted to announce that the fifth iteration of our popular Journal Meeting will be held from 11-14 September 2022 at the historic Wotton House, Surrey. Registration is open now.
Preprints in Development
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As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context.
Submit your next Techniques and Resources paper to Development
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Development regularly publishes Techniques and Resources papers. These manuscripts describe a novel technique, a substantial advance of an existing technique, or a new resource that will have a significant impact on developmental biology research. Find out more here.
Transitions in development: Rashmi Priya
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Rashmi Priya’s research group uses the zebrafish heart as a model system to understand the complex morphogenetic events of organogenesis. We interviewed Rashmi to learn about her career path so far, and to discuss the challenges of starting a lab in the middle of a global pandemic.
The Node Network
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The Node Network is a global directory of developmental and stem cell biologists, designed to help you find speakers, referees, panel members and potential collaborators. Find out more about the Node Network.