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Special Issue: Modelling Development in vitro

HUMAN DEVELOPMENT

Summary: The combination of light-sheet fluorescence and expansion microscopy enables imaging of mature human brain organoids in toto and down to synaptic resolution.

Summary: An optimized protocol is presented that allows morphological, quantifiable differences between the damaged and control human neuronal networks to be detected in three-dimensional cultures.

Summary: Asymmetric segregation of cellular components, which may contribute to the fate and behavior of human neural progenitors, is allowed by a diffusion barrier in the endoplasmic reticulum membrane during cell division.

Summary: The key developmental transcription factor eomesodermin can replace Wnt priming in the differentiation of human embryonic stem cells into mesendoderm.

Summary: Induced pluripotent stem cell-derived model systems reveal defects in early neurogenesis due to dysregulation of key metabolic pathways associated with Leigh syndrome.

Summary: This paper shows the generation of myelinating human oligodendrocytes from dermal fibroblasts using a direct lineage conversion technique, which could be of high interest for regenerative medicine applications.

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