Summary: Mutations in spliceosome components are linked to diseases characterized by tissue-specific phenotypes. This unique role of the spliceosome in vertebrate development is currently being unravelled through new animal models.
Dysregulation of integrin αvβ3 and α5β1 impedes migration of placental endothelial cells in fetal growth restriction
Highlighted Article: Placental dysfunction with impaired placental angiogenesis is a key finding in severe fetal growth restriction. We show that integrin dysregulation within human placental endothelial cells contributes to reduced angiogenic properties.
Young transposable elements rewired gene regulatory networks in human and chimpanzee hippocampal intermediate progenitors
Highlighted Article: Evolution of human and chimpanzee hippocampal development was mediated by the co-option of young retrotransposons into species-specific enhancers.
Summary: The ray-finned fish-specific ETS transcription factor Spi2 is explicitly expressed in hemogenic endothelium and hematopoietic lineages and is involved in hematopoietic stem/progenitor cell and myeloid cell development in zebrafish.
The single Marchantia polymorpha FERONIA homolog reveals an ancestral role in regulating cellular expansion and integrity
Summary: The CrRLK1L family arose in land plants and the Marchantia polymorpha genome contains a single copy, MpFER, which is broadly expressed and regulates cell expansion and cellular integrity.
Plap-1 lineage tracing and single-cell transcriptomics reveal cellular dynamics in the periodontal ligament
Summary: Plap-1 expression can be used to define and isolate the periodontal ligament fibroblast lineage, revealing the role of periodontal ligament cells in tissue homeostasis and repair.
Loss of function of the maternal membrane oestrogen receptor ERα alters expansion of trophoblast cells and impacts mouse fertility
Summary: A point mutation in the oestrogen receptor ERα alters pregnancy, revealing the crucial role for this receptor in maternal tissues for both placental development and delivery.
Highlighted Article: Expression and functional analysis of Notch3 reveals an unexpected tumor-suppressive function for Notch3 in the parous mammary gland through restriction of parity-identified mammary epithelial cell expansion.
Summary: In Nematostella, the ectoderm is patterned along the oral-aboral axis by Wnt/Fz/LRP5/6-mediated β-catenin signalling. In contrast, β-catenin-dependent endoderm specification does not seem to require Fz/LRP5/6.
The RNA ligase RNA terminal phosphate cyclase B regulates mRNA alternative splicing and is required for mouse oocyte development and maintenance
Summary: The important role of RNA terminal phosphate cyclase B-regulated non-canonical splicing in female reproduction and the mechanisms involved.
Omics profiling identifies the regulatory functions of the MAPK/ERK pathway in nephron progenitor metabolism
Summary: A systems biology approach was used to identify the participation of the MAPK/ERK pathway in the regulation of cellular metabolism of nephron progenitors during renal development.
Highlighted Article: Sharp stepwise increase of mature miR-9 is contributed by sequential-temporal activation of distinct loci; a strategy to overcome adaptation and facilitate a transition to a new state of Her6 dynamics/level.
Summary: Haemolymph flow in the Drosophila heart is regulated by highly specialised valve cells that can dynamically change their cell shape via intracellular vesicular cavity generation and redirection of recycling endosomes.
A dual involvement of Protocadherin 18a in stromal cell development guides the formation of a functional hematopoietic niche
Summary: Protocadherin 18a conditions the proper migration of somite-derived stromal cells and their interaction with the endothelial cells with which they constitute the first niche of definitive hematopoiesis in zebrafish.
Interactive CLV3, CLE16 and CLE17 signaling mediates stem cell homeostasis in the Arabidopsis shoot apical meristem
Highlighted Article: The CLE16 and CLE17 peptides play overlapping roles in buffering stem cell homeostasis in Arabidopsis shoot apical meristems by compensating for reduced CLV3 activity.