Issues
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Cover image
Cover Image
Cover: Reconstitution of adult zebrafish skeletons using micro-computed tomography. The images show daw1 mutants, a proportion of which exhibit spinal curves due to a failure of axis development because of perturbed cilia motility. See Research article by Bearce et al. (dev200017).
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RESEARCH HIGHLIGHTS
DEVELOPMENTAL TWISTS
INTERVIEW
REVIEWS
Prostate organogenesis
Summary: This Review summarizes recent technical advances that have provided new insights into androgen regulation, epithelial cell origins and cellular heterogeneity during prostate organogenesis.
The regenerative capacity of neonatal tissues
Summary: This Review highlights common and tissue-specific mechanisms of neonatal regeneration involving cells, signaling pathways and the extracellular matrix.
STEM CELLS AND REGENERATION
SyNPL: Synthetic Notch pluripotent cell lines to monitor and manipulate cell interactions in vitro and in vivo
Summary: Optimised Synthetic Notch circuitry in mouse pluripotent stem cells provides a modular tool with which to monitor cell-cell interactions and program synthetic patterning of cell fates in culture and in embryos.
Embryonic vascular establishment requires protein C receptor-expressing endothelial progenitors
Summary: Genetic fate mapping and single-cell RNA sequencing reveal Procr expression as early as embryonic day 7.5 and demonstrate an essential role for Procr+ endothelial progenitor cells in establishment of the murine vasculature.
Hbxip is essential for murine embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1
Summary: Characterization of the essential role of Hbxip in embryogenesis and embryonic stem cell differentiation, demonstrating that Hbxip is required for activating mTORC1 in these processes.
A non-disruptive and efficient knock-in approach allows fate tracing of resident osteoblast progenitors during repair of vertebral lesions in medaka
Summary: A novel CRISPR/Cas9 homology-directed knock-in approach allows fate tracing of resident collagen10a1 (col10a1) osteoblast progenitors during repair of vertebral lesions in a medaka osteoporosis model while preserving endogenous col10a1 expression.
RESEARCH REPORT
Daw1 regulates the timely onset of cilia motility during development
Summary: Daw1 promotes the onset of timely cilia motility for robust axial straightening during zebrafish development.
RESEARCH ARTICLES
Developmental and evolutionary comparative analysis of a regulatory landscape in mouse and chicken
Highlighted Article: Analyses of the relationships between chromatin architecture and regulatory activities at the HoxD locus show that ancestral transcription patterns can be maintained while new regulations evolve.
Nucleolin loss of function leads to aberrant Fibroblast Growth Factor signaling and craniofacial anomalies
Summary: Loss of function of the ribosomal RNA processing protein Nucleolin results in cartilage and bone hypoplasia in the craniofacial region of zebrafish, which can be rescued by FGF8 supplementation.
A genetic framework for proximal secondary vein branching in the Arabidopsis thaliana embryo
Highlighted Article: A genetic framework involving RPK2, CVP2, CVL1 and OPS reveals how Arabidopsis embryonic cotyledons modulate vascular branching for organ growth by an auxin-independent mechanism.
Feedforward regulatory logic controls the specification-to-differentiation transition and terminal cell fate during Caenorhabditis elegans endoderm development
Summary: This study describes the architecture of the gene regulatory network underlying endoderm development in C. elegans and illuminates the mechanisms that provoke specification, differentiation and commitment during embryogenesis.
The cellular function of ROP GTPase prenylation is important for multicellularity in the moss Physcomitrium patens
Summary: The unicellular state of the moss Physcomitrium patens is caused in part by uncontrolled cell expansion and defects in cell wall integrity, which are regulated by ROP GTPase activation by prenylation.
Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice
Summary: Analysis of Actrt1-knockout mice reveals that ACTRT1, ACTRT2, ACTL7A and ACTL9 form a complex of sperm-specific actin-related proteins, and ACTRT1 in the acroplaxome anchors developing acrosomes to the sperm nucleus.
The extra-embryonic area opaca plays a role in positioning the primitive streak of the early chick embryo
Summary: Two adjacent extra-embryonic tissues, the area opaca and the marginal zone, interact to influence the polarity of the early chick embryo.
Loss of Prm1 leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male mice
Summary: Analysis of protamine 1-deficient mice revealed that heterozygous (Prm1+/−) males are subfertile, whereas homozygous males are infertile, with Prm1 deficiency leading to defective chromatin compaction and sperm damage.
Arabidopsis root responses to salinity depend on pectin modification and cell wall sensing
Summary: Salt-triggered activation of pectin methyl esterase changes pectin in Arabidopsis, inducing at least two pathways: a CrRLK1L-dependent pathway downregulating salt stress responses and a CrRLK1L-independent pathway that activates downstream signaling.
Chondroitin sulfate enhances the barrier function of basement membrane assembled by heparan sulfate
Summary: Disruption of the biosynthesis of heparan sulfate and chondroitin sulfate enhances retinal permeability, suggesting their roles in the formation of the basement membrane and glycocalyx and maintenance of the retinal barrier.
Alignment of the cell long axis by unidirectional tension acts cooperatively with Wnt signalling to establish planar cell polarity
Highlighted Article: Unidirectional tissue tension deriving from morphogenetic movements aligns the cell long axis; this alignment acts cooperatively with Wnt signalling to establish planar cell polarity in Xenopus neuroectoderm.
Uncoupling transcription and translation through miRNA-dependent poly(A) length control in haploid male germ cells
Summary: miRNA-dependent poly(A) length control represents an important mechanism underlying uncoupled translation and transcription in male germ cells undergoing spermiogenesis.
TECHNIQUES AND RESOURCES
Fluorescent cytoskeletal markers reveal associations between the actin and microtubule cytoskeleton in rice cells
Summary: We generated rice cytoskeleton fluorescent marker lines and demonstrated cytoskeletal organization and associations in live rice cells, indicating the utility of the marker lines for investigations in rice biology.
The Company of Biologists Workshops

For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues

Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 30 May 2025.
Meet our 2025 Pathway to Independence (PI) fellows

We are delighted to announce our third cohort of PI fellows - researchers whom we will be supporting as they transition from postdoc to Principal Investigator. Read about the eight talented fellows chosen, whom we're excited to be working with as they navigate the job market.
In preprints
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the Node: Have your say

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