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RESEARCH HIGHLIGHTS

PERSPECTIVE

SPOTLIGHT

Summary: This Spotlight summarizes and discusses single-cell RNA-sequencing studies on mammalian brains, highlighting the remaining gaps and proposing future directions for human brain development research.

REVIEW

Summary: This Review summarizes the formation and function of focal adhesions, highlighting similarities and differences in how these macromolecular assemblies are used in in vitro and in vivo contexts.

STEM CELLS AND REGENERATION

Summary: Multi-omics approaches and functional assays reveal global DNA methylome dynamics and an indispensable role of DNA methyltransferase 1 in hematopoietic stem/progenitor cell generation through repression of Notch signaling.

Highlighted Article: In zebrafish melanocyte regeneration, quiescent McSCs respond by re-expressing a neural crest identity, followed by an Aldh2-dependent metabolic switch to generate progeny.

RESEARCH REPORTS

Highlighted Article: This study resolves previously unidentified subsets of immature and mature thymic fibroblasts, providing further evidence that their homeostasis is controlled by signals provided by developing thymocytes.

Summary: The mechanical properties of the basement membrane of Drosophila egg chambers are mainly determined by Collagen IV.

RESEARCH ARTICLES

Summary: Pen2 is critical for the fate determination of apical progenitors (APs) in the hippocampal neuroepithelium. Pen2 governs the transition of APs to neurons through the γ-secretase/Notch/NeuroD1 pathway.

Summary: GSK3 kinases are required for sperm motility and are part of a sperm-derived signal that triggers the completion of female meiosis after fertilization in Caenorhabditis elegans.

Summary: The interaction between kinases and phosphatases during the DNA damage response, and the regulatory mechanism that exists between the DNA damage checkpoint and the cell cycle.

Highlighted Article: multiple cellular processes mediate secondary palate fusion, including a unique form of streaming collective epithelial migration driven by pulsatile actomyosin contractility.

Summary: Using a range of reporter lines, expression maps of synaptic recognition molecules have been generated, which may provide insights into their function in Drosophila nervous system development.

Summary: Fragile X mental retardation protein regulates sensory neurons dendrite branching morphogenesis through effects on microtubule dynamics and stability, as well by controlling dendritic localization and expression of the actin regulator Chickadee.

Summary: Analysis of 70 Arabidopsis thaliana accessions reveals that natural variation in vegetative phase change is attributable both to miR156 and to genes that regulate vegetative traits independently of miR156.

Summary: Notch signaling acts in nephron segmentation to select early proximal, but not distal, tubule fate downstream of a global role in promoting epithelial growth and maturation in mouse and human.

Summary: Phytochrome-interacting factors orchestrate development of hypocotyl adventitious root by simultaneously activating genes involved in auxin biosynthesis, auxin transport and the transcriptional control of root primordium initiation.

Highlighted Article: In a large developing system, the chick embryo before gastrulation, cells may interpret gradients of positional signals relative to their neighbours to position the primitive streak, establishing bilateral symmetry.

Summary: Lmo7, an adaptor protein at apical junctions, triggers apical constriction by promoting non-muscle myosin II incorporation into actomyosin networks in Xenopus.

Summary: FGF signalling inhibition in cephalochordates induces a loss of anteriormost somites. After FGFR inhibition, the presomitic anterior region cells are incorporated in the anterior notochord which transiently present prechordal plate features.

CORRECTION

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