Issues
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Cover image
Cover Image
Cover: Cross section of seminiferous tubules with developing spermatocytes in murine testis. Spermatocytes undergoing meiosis 1 are marked by SYCP3 (green). Spermatocytes that have reached the pachytene stage show phosphorylated H2A.X (red) sequestered to the sex chromosomes. Nuclei are stained with DAPI (blue). See Research article by Chakraborty and Magnuson (dev200089).
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RESEARCH HIGHLIGHTS
EDITORIAL
PERSPECTIVE
INTERVIEW
REVIEW
Exocrine gland structure-function relationships
Summary: Although exocrine glands have been described individually, this Review discusses exocrine gland structure-function relationships, highlighting similarities and differences for various exocrine glands present throughout the human body.
HUMAN DEVELOPMENT
Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment
Summary: Lineage trajectory modeling identifies multiple human progenitor trophoblast states and defines trophoblast differentiation kinetics, where BCAM-expressing progenitors demonstrate enhanced regenerative ability.
STEM CELLS AND REGENERATION
Colonic healing requires Wnt produced by epithelium as well as Tagln+ and Acta2+ stromal cells
Summary: Aggregated blockage of Wnt release from both epithelium and Tagln+ or Acta2+ stromal cells drastically diminished epithelial regeneration suggesting that colonic recovery from colitis-like injury depends on multiple Wnt-producing sources.
RESEARCH REPORTS
Epithelial Wntless regulates postnatal alveologenesis
Summary: Wnts from the lung epithelium are crucial for the differentiation of the surrounding mesenchyme during early postnatal alveologenesis.
The growth and expansion of meningeal lymphatic networks are affected in craniosynostosis
Summary: A mouse model for craniosynostosis reveals that changes to the local meningeal environment, including dural venous sinus malformations and hypoplastic dura, affect the growth and sprouting of meningeal lymphatic networks.
RESEARCH ARTICLES
ECM-integrin signalling instructs cellular position sensing to pattern the early mouse embryo
Highlighted Article: The importance of patterned cell-extracellular matrix (ECM) interactions in early mouse development: ECM signals can modulate both cell fate and the relative spatial arrangement between cells.
Estrogens regulate early embryonic development of the olfactory sensory system via estrogen-responsive glia
Highlighted Article: Estrogens regulate olfactory development via estrogen-responsive glia, EROB cells and olfaction-mediated neuronal excitability and behaviour in zebrafish embryos.
FGFR2 signaling enhances the SHH-BMP4 signaling axis in early ureter development
Summary: FGFR2 signaling in the epithelium of the distal ureteric bud enhances the SHH-BMP4 signaling axis to drive the coordinated development of the epithelial and mesenchymal tissue primordia in the murine ureter.
INO80 requires a polycomb subunit to regulate the establishment of poised chromatin in murine spermatocytes
Summary: INO80 is required for meiotic progression in spermatocytes, which involves global changes in transcription. These changes are facilitated by INO80 in coordination with H2A.Z and SUZ12 to establish poised chromatin.
Reciprocal EGFR signaling in the anchor cell ensures precise inter-organ connection during Caenorhabditis elegans vulval morphogenesis
Summary: A reciprocal EGF signal from the vulval precursor cells positions the invading anchor cell during Caenorhabditis elegans vulval development to link the vulva and uterus as they form.
Loss of imprinting of the Igf2-H19 ICR1 enhances placental endocrine capacity via sex-specific alterations in signalling pathways in the mouse
Highlighted Article: Imprinting at Igf2-H19 ICR1 regulates endocrine cell formation and function via sexually-dimorphic changes in Pi3k-Akt and Mapk signalling in the mouse.
Embryonic requirements for Tcf12 in the development of the mouse coronal suture
Summary: Tcf12 controls the embryonic behavior of bone precursors to generate the overlapping coronal suture, a fibrous joint uniting major bones at the top of the skull.
Smad4 controls proliferation of interstitial cells in the neonatal kidney
Summary: Mice with Foxd1cre-mediated deletion of Smad4 have interstitial expansion and activated Wnt signaling, revealing a role for TGFβ signaling in the developing renal interstitium.
Msl3 promotes germline stem cell differentiation in female Drosophila
Summary: A component of the dose compensation complex promotes germline differentiation by regulating levels of a ribosomal protein in female Drosophila.
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
