Issues

Summary: Although exocrine glands have been described individually, this Review discusses exocrine gland structure-function relationships, highlighting similarities and differences for various exocrine glands present throughout the human body.

Summary: Lineage trajectory modeling identifies multiple human progenitor trophoblast states and defines trophoblast differentiation kinetics, where BCAM-expressing progenitors demonstrate enhanced regenerative ability.

Summary: Aggregated blockage of Wnt release from both epithelium and Tagln⁺ or Acta2⁺ stromal cells drastically diminished epithelial regeneration suggesting that colonic recovery from colitis-like injury depends on multiple Wnt-producing sources.

Summary: Wnts from the lung epithelium are crucial for the differentiation of the surrounding mesenchyme during early postnatal alveologenesis.

Summary: A mouse model for craniosynostosis reveals that changes to the local meningeal environment, including dural venous sinus malformations and hypoplastic dura, affect the growth and sprouting of meningeal lymphatic networks.

Highlighted Article: The importance of patterned cell-extracellular matrix (ECM) interactions in early mouse development: ECM signals can modulate both cell fate and the relative spatial arrangement between cells.

Highlighted Article: Estrogens regulate olfactory development via estrogen-responsive glia, EROB cells and olfaction-mediated neuronal excitability and behaviour in zebrafish embryos.

Summary: FGFR2 signaling in the epithelium of the distal ureteric bud enhances the SHH-BMP4 signaling axis to drive the coordinated development of the epithelial and mesenchymal tissue primordia in the murine ureter.

Summary: INO80 is required for meiotic progression in spermatocytes, which involves global changes in transcription. These changes are facilitated by INO80 in coordination with H2A.Z and SUZ12 to establish poised chromatin.

Summary: A reciprocal EGF signal from the vulval precursor cells positions the invading anchor cell during Caenorhabditis elegans vulval development to link the vulva and uterus as they form.

Highlighted Article: Imprinting at Igf2-H19 ICR1 regulates endocrine cell formation and function via sexually-dimorphic changes in Pi3k-Akt and Mapk signalling in the mouse.

Summary: Tcf12 controls the embryonic behavior of bone precursors to generate the overlapping coronal suture, a fibrous joint uniting major bones at the top of the skull.

Summary: Mice with Foxd1cre-mediated deletion of Smad4 have interstitial expansion and activated Wnt signaling, revealing a role for TGFβ signaling in the developing renal interstitium.

Summary: A component of the dose compensation complex promotes germline differentiation by regulating levels of a ribosomal protein in female Drosophila.