Issues
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Cover image
Cover Image
Cover: Drosophila eye discs and brain lobes with all neurons in green (labelled using horse radish peroxidase), ganglion mother cells in red (labelled for Prospero), F-actin in magenta (labelled using phalloidin) and nuclei in blue (labelled using DAPI). This image was taken by Tonatiuh Molina Villa at the 2020 MBL Practical Course in Developmental Biology in Quintay, Chile, and was voted by readers of the Node (http://thenode.biologists.com) as the winner of a Development cover competition.
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RESEARCH HIGHLIGHTS
DEVELOPMENT AT A GLANCE
Defining epithelial-mesenchymal transitions in animal development
Summary: This Development at a Glance article provides an overview of EMT models, the concepts of partial EMT and epithelial-mesenchymal plasticity, and the molecular markers associated with EMT.
HYPOTHESIS
Germ cell determination and the developmental origin of germ cell tumors
Summary: When does the germline commit to gametogenesis? Integrating comparative findings, we propose that germ cell determination occurs after PGC colonization of the gonads, and that germ cell tumors reflect a failure of this process.
REVIEW
Development and maintenance of tendons and ligaments
Summary: This Review summarizes the establishment and maintenance of tendon progenitors and their cellular lineages in different anatomical regions and organisms, and discusses the extent to which these processes are conserved between tendons and ligaments.
STEM CELLS AND REGENERATION
Nutrition and PI3K/Akt signaling are required for p38-dependent regeneration
Summary: Ask1 is necessary for integrating nutrient signals to initiate the p38-dependent regeneration of Drosophila wings.
Murine intestinal stem cells are highly sensitive to modulation of the T3/TRα1-dependent pathway
Summary: The thyroid hormone T3 and its nuclear receptor TRα1 affect intestinal stem cell physiology and modulate progenitor differentiation potential.
Arid1a regulates cell cycle exit of transit-amplifying cells by inhibiting the Aurka-Cdk1 axis in mouse incisor
Summary: Arid1a maintains tissue homeostasis through promoting cell cycle exit and differentiation of transit-amplifying cells by inhibiting the Aurka-Cdk1 axis in adult mouse incisor.
RESEARCH ARTICLES
Metabolically active and polyploid renal tissues rely on graded cytoprotection to drive developmental and homeostatic stress resilience
Highlighted Article: The cytoprotective factors Nrf2 and Gadd45 drive resilience to endogenous oxidative and genotoxic stress in metabolically-active Drosophila renal cells during development and homeostasis, and are further elevated following exogenous insult.
Tsga8 is required for spermatid morphogenesis and male fertility in mice
Summary: In undifferentiated mouse spermatogonia, the histone methyltransferase protein KMT2B targets Tsga8, which is involved in the spermiogenic transcriptome and morphogenesis.
Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse
Summary: TBX2 is required to locally restrict otic neurogenesis by repression of FGF signalling and maintenance of TBX1, and TBX2 and TBX3 control patterning in other domains of the otocyst.
Germline sexual fate is determined by the antagonistic action of dmrt1 and foxl3/foxl2 in tilapia
Summary: Dmrt1 and Foxl3 play antagonistic roles in germline sexual fate decision via mutual transcriptional regulation and enable the sexual plasticity of germ cells in tilapia.
The trophoblast clock controls transport across placenta in mice
Highlighted Article: The clock in the placenta trophoblast controls the activity of a xenobiotic efflux transporter, which may gate fetal exposure to substances from the maternal circulation to certain times of day.
PRSS50 is a testis protease responsible for proper sperm tail formation and function
Summary: PRSS50 is a potential genetic factor in MMAF male infertility. Mice lacking this gene have multiple sperm morphological defects, including a novel conjoined phenotype, and impaired fertility.
The tolerance to hypoxia is defined by a time-sensitive response of the gene regulatory network in sea urchin embryos
Summary: The use of hypoxia and redox gradients as morphogens makes sea urchin early development sensitive to environmental hypoxia. This sensitivity decreases later, possibly due to the gene regulatory network structure.
The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development
Highlighted Article: The SRCAP chromatin remodeling complex/Znhit1 promotes mitochondrial maturation and oxidative metabolism during heart development, through H2A.Z deposition.
Development Journal Meeting 2022: From Stem Cells to Human Development
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Following a virtual meeting in 2020, we are delighted to announce that the fifth iteration of our popular Journal Meeting will be held from 11-14 September 2022 at the historic Wotton House, Surrey. Registration is open now.
Special Issue: The Immune System in Development and Regeneration
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Our latest special issue is now complete. It showcases articles that add to the repertoire of immune cell functions during development, repair and regeneration, and provide insights into the developmental pathways leading to the generation and dispersal of these cells. You can watch recordings from our Development presents... webinar celebrating the special issue here.
Propose a new Workshop
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Our Workshops bring together leading experts and early-career researchers from a range of scientific backgrounds. Applications are now open to propose Workshops for 2024, one of which will be held in a Global South country.
Preprints in Development
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As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context. You can read the first article here.
FocalPlane Network launched
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Like the Node Network, the aim of the FocalPlane Network is to facilitate promotion and networking as well as assist those seeking conference speakers, committee members, reviewers or collaborators. We hope that it will help promote diversity in the community. Find out more and join the Network here.