Issues

Summary: This Development at a Glance article provides an overview of EMT models, the concepts of partial EMT and epithelial-mesenchymal plasticity, and the molecular markers associated with EMT.

Summary: When does the germline commit to gametogenesis? Integrating comparative findings, we propose that germ cell determination occurs after PGC colonization of the gonads, and that germ cell tumors reflect a failure of this process.

Summary: This Review summarizes the establishment and maintenance of tendon progenitors and their cellular lineages in different anatomical regions and organisms, and discusses the extent to which these processes are conserved between tendons and ligaments.

Summary: Ask1 is necessary for integrating nutrient signals to initiate the p38-dependent regeneration of Drosophila wings.

Summary: The thyroid hormone T3 and its nuclear receptor TRα1 affect intestinal stem cell physiology and modulate progenitor differentiation potential.

Summary: Arid1a maintains tissue homeostasis through promoting cell cycle exit and differentiation of transit-amplifying cells by inhibiting the Aurka-Cdk1 axis in adult mouse incisor.

Highlighted Article: The cytoprotective factors Nrf2 and Gadd45 drive resilience to endogenous oxidative and genotoxic stress in metabolically-active Drosophila renal cells during development and homeostasis, and are further elevated following exogenous insult.

Summary: In undifferentiated mouse spermatogonia, the histone methyltransferase protein KMT2B targets Tsga8, which is involved in the spermiogenic transcriptome and morphogenesis.

Summary: TBX2 is required to locally restrict otic neurogenesis by repression of FGF signalling and maintenance of TBX1, and TBX2 and TBX3 control patterning in other domains of the otocyst.

Summary: Dmrt1 and Foxl3 play antagonistic roles in germline sexual fate decision via mutual transcriptional regulation and enable the sexual plasticity of germ cells in tilapia.

Highlighted Article: The clock in the placenta trophoblast controls the activity of a xenobiotic efflux transporter, which may gate fetal exposure to substances from the maternal circulation to certain times of day.

Summary: PRSS50 is a potential genetic factor in MMAF male infertility. Mice lacking this gene have multiple sperm morphological defects, including a novel conjoined phenotype, and impaired fertility.

Summary: The use of hypoxia and redox gradients as morphogens makes sea urchin early development sensitive to environmental hypoxia. This sensitivity decreases later, possibly due to the gene regulatory network structure.

Highlighted Article: The SRCAP chromatin remodeling complex/Znhit1 promotes mitochondrial maturation and oxidative metabolism during heart development, through H2A.Z deposition.