Issues

Summary: This Primer discusses the repertoire of regenerative responses shown by plants, despite their rigid cell walls and lack of cell migration, using Arabidopsis as a model.

Summary: This Review is focused on the roles of the major signaling pathways and transcription factors in the specification, morphogenesis and maintenance of the esophagus.

Summary: The peri-implantation window of mammalian development is crucial for primordial germ cell (PGC) specification. This Review discusses the induction of PGCs in key mammalian models, including the new stem cell-based embryo models.

Highlighted Article: Control by extrinsic factors of the sequential activation of HOX genes in axial progenitors is revealed by motor neuron subtype specification in human pluripotent stem cells.

Summary: An efficient strategy is described for the in vitro generation of previously hard-to-produce posterior spinal cord progenitors and MNs exhibiting a thoracic axial and, in particular, preganglionic columnar identity.

Summary: The Drosophila imaginal disc epithelial barrier matures in response to increasing ecdysone levels and re-localization of Cora along the lateral membrane: this limits Dilp8 signaling and determines the duration of regeneration-induced developmental delay.

Summary: During neocortical development, PRDM16 promotes temporal progression of radial glia by regulating a dynamic gene expression program. This activity ensures the transition from mid- to late-neurogenesis.

Summary: Pancreatic β cells require Groucho co-repressors during development to repress a master regulator of the liver genetic program, Foxa1, and to allow Neurod1-mediated β cell expansion.

Highlighted Article: An in vitro study inferring that successful follicle assembly under the circulating physiological level of estrogen in the mouse fetus is achieved by liver-produced alpha-fetoprotein.

Summary: Actomyosin contractility guides the architectures of epithelial organs and regulates gene expression for progenitor cell patterning during branching morphogenesis.

Summary:abnormal pollen 1 encodes an L-type lectin receptor-like kinase and affects pollen starch accumulation through interaction with and phosphorylation of OsUGP2.

Highlighted Article: Evf2 lncRNA-enhancer targeting and long-range gene repression occur through regulation of pioneer transcription factor Sox2 in large subnuclear domains, controlling domain sizes, localization, site-specific Sox2 recruitment and DNA binding.

Summary: Calculation of a gene co-expression network for pancreatic β-cell development reveals crucial roles for the clustered protocadherin genes and Zfp800 in pancreas development.

Summary: Single copies of short epitope tags were inserted into proteins of interest, allowing for in vivo binding and manipulation of the resulting chimeric proteins by genetically encoded epitope binders.