Issues
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Cover image
Cover Image
Cover: Cross-section of a barley flower immunolabelled to show demethylesterified pectin (magenta) in the nucellus, and beta-(1-3;1-4)-glucan (green) in multiple organs. Cell wall autofluorescence is blue. The ovule contains a prominent vacuole and resides within the carpel, flanked by two lodicules and three anther filaments and enclosed by the palea (left) and lemma (right). See Research article by Shoesmith et al. (dev194894).
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RESEARCH HIGHLIGHTS
INTERVIEW
DEVELOPMENT AT A GLANCE
TGFβ family signaling and development
Summary: This Development at a Glance article provides an overview of signal transduction mechanisms and developmental functions of TGFβ family proteins.
REVIEWS
Expansion and innovation in auxin signaling: where do we grow from here?
Summary: A Review of new work that clarifies the evolutionary origins of auxin signaling, and strengthens the link between diversification of auxin signaling components and innovation in plant form.
The ECM as a driver of heart development and repair
Summary: Cardiac development encompasses the formation and complex morphogenesis of a linear tube. This Review explores how cardiac extracellular matrix composition changes to support specific processes during heart morphogenesis.
STEM CELLS AND REGENERATION
Mechanosensory neuron regeneration in adult Drosophila
Summary: Refined lineage tracing and longitudinal live imaging identifies production of adult Drosophila mechanosensory neurons, the functional counterparts to vertebrate hair cells, and their enhanced regeneration through pharmacological administration.
Hormone receptor 4 is required in muscles and distinct ovarian cell types to regulate specific steps of Drosophila oogenesis
Highlighted Article: The nuclear receptor Hr4 is required in muscles and the ovary to control specific steps of oogenesis in adult Drosophila.
ERECTA family signaling constrains CLAVATA3 and WUSCHEL to the center of the shoot apical meristem
Summary: ERf signaling restricts the width of the shoot apical meristem, a structure that generates above-ground plant organs, by inhibiting expression of two principal regulators, CLV3 and WUS, at its periphery.
Differential effects of commensal bacteria on progenitor cell adhesion, division symmetry and tumorigenesis in the Drosophila intestine
Summary: Commensal Lactobacillus brevis disrupts progenitor cell adhesion, promotes symmetric stem cell divisions and stimulates tumor growth in the Drosophila intestine.
RESEARCH ARTICLES
The homotetramerization of a GPCR transmits the 20-hydroxyecdysone signal and increases its entry into cells for insect metamorphosis
Summary: Homotetramerization of ErGPCR-3 induced by 20E binding suggests a GPCR-mediated mechanism of 20E cell entry, which provides important implications for controlling wing disk and midgut development during metamorphosis.
The GTPase Rab8 differentially controls the long- and short-range activity of the Hedgehog morphogen gradient by regulating Hedgehog apico-basal distribution
Highlighted Article: Interfering with Rab8 function reveals that Hedgehog activity is functionally distributed between apically and laterally released pools, a process that is crucial for the establishment of the Hedgehog gradient.
APETALA2 functions as a temporal factor together with BLADE-ON-PETIOLE2 and MADS29 to control flower and grain development in barley
Summary: An APETALA2-like transcription factor has profound roles in pre-fertilisation and post-fertilisation reproductive development in barley.
Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse
Summary:In vivo evidence that retinoic acid directly induces the meiotic gatekeeper gene Stra8 in germ cells of the mouse fetal ovary.
The intrinsically disordered protein SPE-18 promotes localized assembly of MSP in Caenorhabditis elegans spermatocytes
Summary: The intrinsically disordered protein SPE-18 is identified as an essential factor for C. elegans spermatogenesis, functioning with the kinase SPE-6 to sequester the cytoskeletal element MSP into fibrous bodies.
Sperm-borne miR-202 targets SEPT7 and regulates first cleavage of bovine embryos via cytoskeletal remodeling
Summary: We have clarified how sperm-borne miR-202 regulates the first cleavage process of bovine embryos by SEPT7 and demonstrate the potential of sperm-borne miRNAs for improving the efficiency of somatic cell nuclear transfer.
Golgi localization of the LIN-2/7/10 complex points to a role in basolateral secretion of LET-23 EGFR in the Caenorhabditis elegans vulval precursor cells
Summary: Expression and localization analyses revealed that LIN-10 recruits LIN-2 and LIN-7 to Golgi, consistent with targeting rather than tethering the epidermal growth factor receptor to the basolateral membrane in Caenorhabditis elegans.
Temporally regulated cell migration is sensitive to variation in body size
Highlighted Article: The final position of a migrating neuroblast is rather invariant in C. elegans. However, consistent with its migration arrest being temporally regulated, its final position is sensitive to body size.
TECHNIQUES AND RESOURCES
Mosaic CRISPR-stop enables rapid phenotyping of nonsense mutations in essential genes
Summary: We have established a quick genetic method, CRISPR-stop, that reveals the functions of lethal genes without the need to generate conditional knockout mice and breeding.
PREPRINT HIGHLIGHTS
Development Journal Meeting 2022: From Stem Cells to Human Development
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Following a virtual meeting in 2020, we are delighted to announce that the fifth iteration of our popular Journal Meeting will be held from 11-14 September 2022 at the historic Wotton House, Surrey. Registration is open now.
Special Issue: The Immune System in Development and Regeneration
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Our latest special issue is now complete. It showcases articles that add to the repertoire of immune cell functions during development, repair and regeneration, and provide insights into the developmental pathways leading to the generation and dispersal of these cells. You can watch recordings from our Development presents... webinar celebrating the special issue here.
Propose a new Workshop
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Our Workshops bring together leading experts and early-career researchers from a range of scientific backgrounds. Applications are now open to propose Workshops for 2024, one of which will be held in a Global South country.
Preprints in Development
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As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context. You can read the first article here.
FocalPlane Network launched
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Like the Node Network, the aim of the FocalPlane Network is to facilitate promotion and networking as well as assist those seeking conference speakers, committee members, reviewers or collaborators. We hope that it will help promote diversity in the community. Find out more and join the Network here.