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RESEARCH HIGHLIGHTS

INTERVIEW

DEVELOPMENT AT A GLANCE

Summary: This Development at a Glance article provides an overview of signal transduction mechanisms and developmental functions of TGFβ family proteins.

REVIEWS

Summary: A Review of new work that clarifies the evolutionary origins of auxin signaling, and strengthens the link between diversification of auxin signaling components and innovation in plant form.

Summary: Cardiac development encompasses the formation and complex morphogenesis of a linear tube. This Review explores how cardiac extracellular matrix composition changes to support specific processes during heart morphogenesis.

STEM CELLS AND REGENERATION

Summary: Refined lineage tracing and longitudinal live imaging identifies production of adult Drosophila mechanosensory neurons, the functional counterparts to vertebrate hair cells, and their enhanced regeneration through pharmacological administration.

Highlighted Article: The nuclear receptor Hr4 is required in muscles and the ovary to control specific steps of oogenesis in adult Drosophila.

Summary: ERf signaling restricts the width of the shoot apical meristem, a structure that generates above-ground plant organs, by inhibiting expression of two principal regulators, CLV3 and WUS, at its periphery.

Summary: Commensal Lactobacillus brevis disrupts progenitor cell adhesion, promotes symmetric stem cell divisions and stimulates tumor growth in the Drosophila intestine.

RESEARCH ARTICLES

Summary: Homotetramerization of ErGPCR-3 induced by 20E binding suggests a GPCR-mediated mechanism of 20E cell entry, which provides important implications for controlling wing disk and midgut development during metamorphosis.

Highlighted Article: Interfering with Rab8 function reveals that Hedgehog activity is functionally distributed between apically and laterally released pools, a process that is crucial for the establishment of the Hedgehog gradient.

Summary: An APETALA2-like transcription factor has profound roles in pre-fertilisation and post-fertilisation reproductive development in barley.

Summary:In vivo evidence that retinoic acid directly induces the meiotic gatekeeper gene Stra8 in germ cells of the mouse fetal ovary.

Summary: The intrinsically disordered protein SPE-18 is identified as an essential factor for C. elegans spermatogenesis, functioning with the kinase SPE-6 to sequester the cytoskeletal element MSP into fibrous bodies.

Summary: We have clarified how sperm-borne miR-202 regulates the first cleavage process of bovine embryos by SEPT7 and demonstrate the potential of sperm-borne miRNAs for improving the efficiency of somatic cell nuclear transfer.

Summary: Expression and localization analyses revealed that LIN-10 recruits LIN-2 and LIN-7 to Golgi, consistent with targeting rather than tethering the epidermal growth factor receptor to the basolateral membrane in Caenorhabditis elegans.

Highlighted Article: The final position of a migrating neuroblast is rather invariant in C. elegans. However, consistent with its migration arrest being temporally regulated, its final position is sensitive to body size.

TECHNIQUES AND RESOURCES

Summary: We have established a quick genetic method, CRISPR-stop, that reveals the functions of lethal genes without the need to generate conditional knockout mice and breeding.

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