DEVELOPMENT AT A GLANCE
Summary: A Review of new work that clarifies the evolutionary origins of auxin signaling, and strengthens the link between diversification of auxin signaling components and innovation in plant form.
Summary: Cardiac development encompasses the formation and complex morphogenesis of a linear tube. This Review explores how cardiac extracellular matrix composition changes to support specific processes during heart morphogenesis.
STEM CELLS AND REGENERATION
Summary: Refined lineage tracing and longitudinal live imaging identifies production of adult Drosophila mechanosensory neurons, the functional counterparts to vertebrate hair cells, and their enhanced regeneration through pharmacological administration.
Hormone receptor 4 is required in muscles and distinct ovarian cell types to regulate specific steps of Drosophila oogenesis
Highlighted Article: The nuclear receptor Hr4 is required in muscles and the ovary to control specific steps of oogenesis in adult Drosophila.
Summary: ERf signaling restricts the width of the shoot apical meristem, a structure that generates above-ground plant organs, by inhibiting expression of two principal regulators, CLV3 and WUS, at its periphery.
Differential effects of commensal bacteria on progenitor cell adhesion, division symmetry and tumorigenesis in the Drosophila intestine
Summary: Commensal Lactobacillus brevis disrupts progenitor cell adhesion, promotes symmetric stem cell divisions and stimulates tumor growth in the Drosophila intestine.
The homotetramerization of a GPCR transmits the 20-hydroxyecdysone signal and increases its entry into cells for insect metamorphosis
Summary: Homotetramerization of ErGPCR-3 induced by 20E binding suggests a GPCR-mediated mechanism of 20E cell entry, which provides important implications for controlling wing disk and midgut development during metamorphosis.
The GTPase Rab8 differentially controls the long- and short-range activity of the Hedgehog morphogen gradient by regulating Hedgehog apico-basal distribution
Highlighted Article: Interfering with Rab8 function reveals that Hedgehog activity is functionally distributed between apically and laterally released pools, a process that is crucial for the establishment of the Hedgehog gradient.
APETALA2 functions as a temporal factor together with BLADE-ON-PETIOLE2 and MADS29 to control flower and grain development in barley
Summary: An APETALA2-like transcription factor has profound roles in pre-fertilisation and post-fertilisation reproductive development in barley.
Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse
Summary:In vivo evidence that retinoic acid directly induces the meiotic gatekeeper gene Stra8 in germ cells of the mouse fetal ovary.
The intrinsically disordered protein SPE-18 promotes localized assembly of MSP in Caenorhabditis elegans spermatocytes
Summary: The intrinsically disordered protein SPE-18 is identified as an essential factor for C. elegans spermatogenesis, functioning with the kinase SPE-6 to sequester the cytoskeletal element MSP into fibrous bodies.
Sperm-borne miR-202 targets SEPT7 and regulates first cleavage of bovine embryos via cytoskeletal remodeling
Summary: We have clarified how sperm-borne miR-202 regulates the first cleavage process of bovine embryos by SEPT7 and demonstrate the potential of sperm-borne miRNAs for improving the efficiency of somatic cell nuclear transfer.
Golgi localization of the LIN-2/7/10 complex points to a role in basolateral secretion of LET-23 EGFR in the Caenorhabditis elegans vulval precursor cells
Summary: Expression and localization analyses revealed that LIN-10 recruits LIN-2 and LIN-7 to Golgi, consistent with targeting rather than tethering the epidermal growth factor receptor to the basolateral membrane in Caenorhabditis elegans.
Highlighted Article: The final position of a migrating neuroblast is rather invariant in C. elegans. However, consistent with its migration arrest being temporally regulated, its final position is sensitive to body size.
TECHNIQUES AND RESOURCES
Summary: We have established a quick genetic method, CRISPR-stop, that reveals the functions of lethal genes without the need to generate conditional knockout mice and breeding.