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RESEARCH HIGHLIGHTS

OBITUARY

Summary: Uwe Drescher commemorates the life and work of Friedrich Bonhoeffer, whose pioneering work – including the development of innovative in vitro assays – led to important discoveries in the field of axon guidance and neural development.

INTERVIEW

REVIEWS

Summary: This Review highlights the mechanisms by which the dynamic properties of the mitochondria impact human cortical development.

Summary: This Review looks at the biology of the progenitors that generate the components that make up the embryonic body axis, such as the spinal cord and vertebral column, as well as their in vitro production and potential applications in disease modelling and regenerative medicine.

Summary: Within the developing head, tissues undergo cell-fate transitions to shape the forming structures. This Review focuses on the processes of EMT and MET.

HUMAN DEVELOPMENT

Summary: A detailed 4D anatomical description of the human upper limb musculature through embryonic development reveals important events that enable nascent muscle bundles to form correctly.

STEM CELLS AND REGENERATION

Summary: Hes1 overexpression leads to expansion of the embryonic neural stem cell pool, including basal radial glia-like cells, and enhanced neurogenesis in the postnatal brain by expanding the neural stem cell reservoir.

Highlighted Article: The crucial role of microenvironmental oxygen in epithelial stem cell compartments is shown using a mouse incisor model, also providing insights into the associated signaling pathway regulation.

RESEARCH ARTICLES

Highlighted Article: This study tests the epidermal growth theory by investigating the roles of CLV3 and DET3 in sustaining flowering stem structural integrity.

Highlighted Article: The dome-shaped outlines of plant root tips converge to a parameter-free catenary curve seen in arch bridges, owing to a constraint from anisotropic and localized tissue growth.

Highlighted Article: Dynamic assembly of Collagen IV from multiple tissues is essential for cell intercalation, the production of functional, mechanically resistant ovarioles and, hence, fertility.

Summary: Experiments and modeling reveal sharp boundaries of gene expression in the vertebrate neural tube depend on the dynamics of the gene regulatory network that patterns the tissue.

Summary: The three different isoforms of KIF2A expressed during embryonic corticogenesis have different roles, and proximity ligation proteomics shows the presence of isoform-specific protein interactomes.

Summary: Vasohibin 1-mediated detyrosination of endothelial microtubules is selectively required for the control of venous secondary sprouting and subsequent formation of functional lymphatics in the zebrafish trunk.

Summary: Instead of providing positional information, HoxB genes regulate the delamination of neuronally differentiating cells by controlling the expression of leucine zipper tumor suppressor 1.

Summary: Loss of Gpr161 leads to reduced PKA activity and derepression of Hedgehog signalling in zebrafish. Additionally, PKA-mediated phosphorylation of Gpr161 controls its ciliary localisation to fine-tune Hedgehog signalling activity.

Summary: A spatially restricted program of retinoic acid production and degradation is established by Zic1 and its targets Cyp26c1 and Pitx2c to pattern the precursor region for all paired sensory organs.

Summary: Ciliopathic micrognathia is caused by aberrant Gli-mediated signaling, which results in impaired differentiation of neural crest cells, failed osteoblast maturation and excessive bone resorption.

CORRECTION

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