Issues
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Cover image
Cover Image
Cover: A high-magnification scanning electron microscopy image of a cracked stem in a clv3 det3-1 mutant. Higher proliferation in stem inner tissues increases mechanical stress in the epidermis; when combined with weaker cell walls, this leads to loss of tissue integrity and cracking. See Research article by Asaoka et al. (dev198028)
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RESEARCH HIGHLIGHTS
OBITUARY
Obituary: Friedrich Bonhoeffer (1932-2021)
Summary: Uwe Drescher commemorates the life and work of Friedrich Bonhoeffer, whose pioneering work – including the development of innovative in vitro assays – led to important discoveries in the field of axon guidance and neural development.
INTERVIEW
REVIEWS
Dynamic properties of mitochondria during human corticogenesis
Summary: This Review highlights the mechanisms by which the dynamic properties of the mitochondria impact human cortical development.
Understanding axial progenitor biology in vivo and in vitro
Summary: This Review looks at the biology of the progenitors that generate the components that make up the embryonic body axis, such as the spinal cord and vertebral column, as well as their in vitro production and potential applications in disease modelling and regenerative medicine.
Craniofacial transitions: the role of EMT and MET during head development
Summary: Within the developing head, tissues undergo cell-fate transitions to shape the forming structures. This Review focuses on the processes of EMT and MET.
HUMAN DEVELOPMENT
4D formation of human embryonic forelimb musculature
Summary: A detailed 4D anatomical description of the human upper limb musculature through embryonic development reveals important events that enable nascent muscle bundles to form correctly.
STEM CELLS AND REGENERATION
Hes1 overexpression leads to expansion of embryonic neural stem cell pool and stem cell reservoir in the postnatal brain
Summary: Hes1 overexpression leads to expansion of the embryonic neural stem cell pool, including basal radial glia-like cells, and enhanced neurogenesis in the postnatal brain by expanding the neural stem cell reservoir.
Oxygen regulates epithelial stem cell proliferation via RhoA-actomyosin-YAP/TAZ signal in mouse incisor
Highlighted Article: The crucial role of microenvironmental oxygen in epithelial stem cell compartments is shown using a mouse incisor model, also providing insights into the associated signaling pathway regulation.
RESEARCH ARTICLES
Stem integrity in Arabidopsis thaliana requires a load-bearing epidermis
Highlighted Article: This study tests the epidermal growth theory by investigating the roles of CLV3 and DET3 in sustaining flowering stem structural integrity.
Tissue growth constrains root organ outlines into an isometrically scalable shape
Highlighted Article: The dome-shaped outlines of plant root tips converge to a parameter-free catenary curve seen in arch bridges, owing to a constraint from anisotropic and localized tissue growth.
A dynamic and mosaic basement membrane controls cell intercalation in Drosophila ovaries
Highlighted Article: Dynamic assembly of Collagen IV from multiple tissues is essential for cell intercalation, the production of functional, mechanically resistant ovarioles and, hence, fertility.
Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks
Summary: Experiments and modeling reveal sharp boundaries of gene expression in the vertebrate neural tube depend on the dynamics of the gene regulatory network that patterns the tissue.
Roles of developmentally regulated KIF2A alternative isoforms in cortical neuron migration and differentiation
Summary: The three different isoforms of KIF2A expressed during embryonic corticogenesis have different roles, and proximity ligation proteomics shows the presence of isoform-specific protein interactomes.
Vasohibin 1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk
Summary: Vasohibin 1-mediated detyrosination of endothelial microtubules is selectively required for the control of venous secondary sprouting and subsequent formation of functional lymphatics in the zebrafish trunk.
HoxB genes regulate neuronal delamination in the trunk neural tube by controlling the expression of Lzts1
Summary: Instead of providing positional information, HoxB genes regulate the delamination of neuronally differentiating cells by controlling the expression of leucine zipper tumor suppressor 1.
Feedback control of the Gpr161-Gαs-PKA axis contributes to basal Hedgehog repression in zebrafish
Summary: Loss of Gpr161 leads to reduced PKA activity and derepression of Hedgehog signalling in zebrafish. Additionally, PKA-mediated phosphorylation of Gpr161 controls its ciliary localisation to fine-tune Hedgehog signalling activity.
Retinoic acid production, regulation and containment through Zic1, Pitx2c and Cyp26c1 control cranial placode specification
Summary: A spatially restricted program of retinoic acid production and degradation is established by Zic1 and its targets Cyp26c1 and Pitx2c to pattern the precursor region for all paired sensory organs.
Ciliopathic micrognathia is caused by aberrant skeletal differentiation and remodeling
Summary: Ciliopathic micrognathia is caused by aberrant Gli-mediated signaling, which results in impaired differentiation of neural crest cells, failed osteoblast maturation and excessive bone resorption.
CORRECTION
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Development presents… Outstanding Paper Prize Finalists

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