Issues
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Cover image
Cover Image
Cover: Immunostaining of differentiated myotubes generated from C2C12 myoblasts overexpressing SMAD2. Myosin heavy chain expression is in green and nuclei are revealed with DAPI (blue). See Research article by Lamarche et al. (dev195495)
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RESEARCH HIGHLIGHTS
EDITORIAL
A new society for regenerative biologists
Summary: We announce the launch of the International Society for Regenerative Biology – a new alliance for scientists interested in regenerative biology and its applications.
INTERVIEW
MEETING REVIEW
Cellular plasticity at the nexus of development and disease
Summary: A summary of the October 2020 Keystone eSymposia ‘Tissue Plasticity: Preservation and Alteration of Cellular Identity’.
REVIEWS
Gut innervation and enteric nervous system development: a spatial, temporal and molecular tour de force
Summary: This Review highlights the importance of gut innervation during embryonic development to assure proper gut function, specifically addressing the spatiotemporal and key molecular aspects along the longitudinal and circumferential axes of the gut.
Stem cell quiescence: the challenging path to activation
Summary: This Review provides a perspective of the quiescent state of adult stem cells and discusses how recent technical advances could help overcome some of the challenges in the field.
Aristotle, Buddhist scripture and embryology in ancient Mexico: building inclusion by re-thinking what counts as the history of developmental biology
Summary: This Review highlights the rich history of embryological thinking in Asia and Latin America, challenging the European-centric view of the history of scientific investigation and discovery in developmental biology.
STEM CELLS AND REGENERATION
SMAD2 promotes myogenin expression and terminal myogenic differentiation
Highlighted Article: TGFβ and SMAD2 are normally associated with inhibition of myogenesis, but SMAD2 also has a pro-myogenic role during terminal myogenic differentiation, through regulation of Myog and Klf4 expression.
Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling
Summary: Suppression of P53 signaling by the RNA-degrading exosome complex is essential for normal cell survival and brain development.
RESEARCH ARTICLES
Dynein-dynactin segregate meiotic chromosomes in C. elegans spermatocytes
Summary: Characterization of a disease-associated p150Glued mutation in C. elegans reveals that the microtubule-based motor dynein drives the segregation of homologous chromosomes during spermatocyte meiosis.
Brachyury controls Ciona notochord fate as part of a feed-forward network
Summary: In the simple chordate Ciona, the notochord-specific transcription factor Brachyury acts together with Foxa.a as part of a densely interlocked FGF-dependent feed-forward network.
CAMSAP3 is required for mTORC1-dependent ependymal cell growth and lateral ventricle shaping in mouse brains
Highlighted Article: CAMSAP3, which mediates non-centrosomal microtubule assembly, is required for mTORC1-dependent maturation of ependymal cells at the neocortex of developing mouse brains. Loss of CAMSAP3 causes deformation of the lateral ventricles.
Robustness and timing of cellular differentiation through population-based symmetry breaking
Highlighted Article: Description of a cell-cell communication mechanism that within a growing population of precursor cells autonomously achieves timing and subsequent differentiation into robust cell-type proportions, and ensures their reliable recovery upon perturbation.
Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart
Highlighted Article: Tissue-resident macrophages are indispensable mediators of lymphatic vessel formation during heart development, and function to remodel the vascular plexus.
Rab11fip5 regulates telencephalon development via ephrinB1 recycling
Summary: Rab11fip5, genetic mutations of which are associated with autism spectrum disorders in humans, plays a role in regulating telencephalon development via recycling of the crucial cargo ephrinB1.
PREPRINT HIGHLIGHTS
Development Journal Meeting 2022: From Stem Cells to Human Development
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Following a virtual meeting in 2020, we are delighted to announce that the fifth iteration of our popular Journal Meeting will be held from 11-14 September 2022 at the historic Wotton House, Surrey. Registration is open now.
Special Issue: The Immune System in Development and Regeneration
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Our latest special issue is now complete. It showcases articles that add to the repertoire of immune cell functions during development, repair and regeneration, and provide insights into the developmental pathways leading to the generation and dispersal of these cells. You can watch recordings from our Development presents... webinar celebrating the special issue here.
Propose a new Workshop
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Our Workshops bring together leading experts and early-career researchers from a range of scientific backgrounds. Applications are now open to propose Workshops for 2024, one of which will be held in a Global South country.
Preprints in Development
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As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context. You can read the first article here.
FocalPlane Network launched
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Like the Node Network, the aim of the FocalPlane Network is to facilitate promotion and networking as well as assist those seeking conference speakers, committee members, reviewers or collaborators. We hope that it will help promote diversity in the community. Find out more and join the Network here.