Issues
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Cover image
Cover Image
Cover: Immunostaining of differentiated myotubes generated from C2C12 myoblasts overexpressing SMAD2. Myosin heavy chain expression is in green and nuclei are revealed with DAPI (blue). See Research article by Lamarche et al. (dev195495)
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RESEARCH HIGHLIGHTS
EDITORIAL
A new society for regenerative biologists
Summary: We announce the launch of the International Society for Regenerative Biology – a new alliance for scientists interested in regenerative biology and its applications.
INTERVIEW
MEETING REVIEW
Cellular plasticity at the nexus of development and disease
Summary: A summary of the October 2020 Keystone eSymposia ‘Tissue Plasticity: Preservation and Alteration of Cellular Identity’.
REVIEWS
Gut innervation and enteric nervous system development: a spatial, temporal and molecular tour de force
Summary: This Review highlights the importance of gut innervation during embryonic development to assure proper gut function, specifically addressing the spatiotemporal and key molecular aspects along the longitudinal and circumferential axes of the gut.
Stem cell quiescence: the challenging path to activation
Summary: This Review provides a perspective of the quiescent state of adult stem cells and discusses how recent technical advances could help overcome some of the challenges in the field.
Aristotle, Buddhist scripture and embryology in ancient Mexico: building inclusion by re-thinking what counts as the history of developmental biology
Summary: This Review highlights the rich history of embryological thinking in Asia and Latin America, challenging the European-centric view of the history of scientific investigation and discovery in developmental biology.
STEM CELLS AND REGENERATION
SMAD2 promotes myogenin expression and terminal myogenic differentiation
Highlighted Article: TGFβ and SMAD2 are normally associated with inhibition of myogenesis, but SMAD2 also has a pro-myogenic role during terminal myogenic differentiation, through regulation of Myog and Klf4 expression.
Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling
Summary: Suppression of P53 signaling by the RNA-degrading exosome complex is essential for normal cell survival and brain development.
RESEARCH ARTICLES
Dynein-dynactin segregate meiotic chromosomes in C. elegans spermatocytes
Summary: Characterization of a disease-associated p150Glued mutation in C. elegans reveals that the microtubule-based motor dynein drives the segregation of homologous chromosomes during spermatocyte meiosis.
Brachyury controls Ciona notochord fate as part of a feed-forward network
Summary: In the simple chordate Ciona, the notochord-specific transcription factor Brachyury acts together with Foxa.a as part of a densely interlocked FGF-dependent feed-forward network.
CAMSAP3 is required for mTORC1-dependent ependymal cell growth and lateral ventricle shaping in mouse brains
Highlighted Article: CAMSAP3, which mediates non-centrosomal microtubule assembly, is required for mTORC1-dependent maturation of ependymal cells at the neocortex of developing mouse brains. Loss of CAMSAP3 causes deformation of the lateral ventricles.
Robustness and timing of cellular differentiation through population-based symmetry breaking
Highlighted Article: Description of a cell-cell communication mechanism that within a growing population of precursor cells autonomously achieves timing and subsequent differentiation into robust cell-type proportions, and ensures their reliable recovery upon perturbation.
Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart
Highlighted Article: Tissue-resident macrophages are indispensable mediators of lymphatic vessel formation during heart development, and function to remodel the vascular plexus.
Rab11fip5 regulates telencephalon development via ephrinB1 recycling
Summary: Rab11fip5, genetic mutations of which are associated with autism spectrum disorders in humans, plays a role in regulating telencephalon development via recycling of the crucial cargo ephrinB1.
PREPRINT HIGHLIGHTS
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK.
Pathway to independence: perspectives on the future
In this Perspective, our second cohort of Pathway to Independence (PI) fellows showcase their research interests and thoughts on the future of the field of developmental biology. These talented postdocs cover topics as diverse as plant development, tissue engineering and adaptation to climate change. Look out for an announcement about the next call for applications later this year to become a Pathway to Independence fellow.
Development presents…
Development is excited to host a webinar series showcasing the latest developmental biology and stem cell research. The webinars are chaired each month by a different Development Editor, who invites talks from authors of exciting new papers and preprints. Visit Development presents... on the Node to see which topics are coming up and to catch up on recordings of past webinars.
The fascinating world of developmental biology
Development, British Society of Developmental Biology and Cambridge Filmworks teamed up to produce a documentary showcasing the wonder and the importance of the developmental biology field. We hope this video will help to promote our field and inspire the next generation of developmental biologists. We invite you to watch, enjoy and – most importantly - share this movie.
Modelling Plant Stem Cells: Evolution, Development and Regeneration
Early-career researchers can now apply for a funded place for the Modelling Plant Stem Cells: Evolution, Development and Regeneration Workshop happening on 18-21 May 2025. This is a great opportunity that could enhance your career in various ways. Application deadline: Friday 15 November 2024.