Summary: A summary of the October 2020 Keystone eSymposia ‘Tissue Plasticity: Preservation and Alteration of Cellular Identity’.
Gut innervation and enteric nervous system development: a spatial, temporal and molecular tour de force
Summary: This Review highlights the importance of gut innervation during embryonic development to assure proper gut function, specifically addressing the spatiotemporal and key molecular aspects along the longitudinal and circumferential axes of the gut.
Summary: This Review provides a perspective of the quiescent state of adult stem cells and discusses how recent technical advances could help overcome some of the challenges in the field.
Aristotle, Buddhist scripture and embryology in ancient Mexico: building inclusion by re-thinking what counts as the history of developmental biology
Summary: This Review highlights the rich history of embryological thinking in Asia and Latin America, challenging the European-centric view of the history of scientific investigation and discovery in developmental biology.
STEM CELLS AND REGENERATION
Highlighted Article: TGFβ and SMAD2 are normally associated with inhibition of myogenesis, but SMAD2 also has a pro-myogenic role during terminal myogenic differentiation, through regulation of Myog and Klf4 expression.
Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling
Summary: Suppression of P53 signaling by the RNA-degrading exosome complex is essential for normal cell survival and brain development.
Highlighted Article: Maternally deposited histone-modifying enzymes prevent the ectopic expression of germline genes in somatic tissues and developmental delay by regulating the inheritance of histone methylation.
Summary: Characterization of a disease-associated p150Glued mutation in C. elegans reveals that the microtubule-based motor dynein drives the segregation of homologous chromosomes during spermatocyte meiosis.
Summary: In the simple chordate Ciona, the notochord-specific transcription factor Brachyury acts together with Foxa.a as part of a densely interlocked FGF-dependent feed-forward network.
CAMSAP3 is required for mTORC1-dependent ependymal cell growth and lateral ventricle shaping in mouse brains
Highlighted Article: CAMSAP3, which mediates non-centrosomal microtubule assembly, is required for mTORC1-dependent maturation of ependymal cells at the neocortex of developing mouse brains. Loss of CAMSAP3 causes deformation of the lateral ventricles.
Highlighted Article: Description of a cell-cell communication mechanism that within a growing population of precursor cells autonomously achieves timing and subsequent differentiation into robust cell-type proportions, and ensures their reliable recovery upon perturbation.
Highlighted Article: Tissue-resident macrophages are indispensable mediators of lymphatic vessel formation during heart development, and function to remodel the vascular plexus.
Summary: Rab11fip5, genetic mutations of which are associated with autism spectrum disorders in humans, plays a role in regulating telencephalon development via recycling of the crucial cargo ephrinB1.