Issues
-
Cover image
Cover Image
Cover: Piezo1 affects the dynamic of cell protrusion in Xenopus neural crest. Time-lapse color-coded projection of Piezo1-depleted neural crest. Different look-up tables were used to observe protrusion dynamics. See Research article by Coutiño and Mayor (dev200001)
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
RESEARCH HIGHLIGHTS
INTERVIEWS
PRIMER
Oxygen-sensing mechanisms in development and tissue repair
Summary: This Primer provides an overview of molecular and cellular mechanisms of oxygen sensing and hypoxia signaling, and summarizes loss-of-function phenotypes in development, highlighting clinical relevance by focusing on angiogenesis and tissue ischemia.
REVIEW
Tissue and cell interactions in mammalian PGC development
Summary: This Review summarises recent research revealing that primordial germ cell (PGC) development depends on interactions with the surrounding somatic cells and tissues, and that this co-development is crucial for PGC specification, migration and maturation.
HUMAN DEVELOPMENT
Characterization and staging of outer plexiform layer development in human retina and retinal organoids
Summary: This study identifies early stages in the formation of synapses between the neurons of the human retina and demonstrates a recapitulation of this process in human stem cell-derived retinal organoids.
STEM CELLS AND REGENERATION
Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species
Highlighted Article: We report the derivation of similar, stable and continuously expandable pluripotent stem cells related to embryonic disc epiblast from embryos of pig, sheep and cow.
Skeletal stem cell fate defects caused by Pdgfrb activating mutation
Highlighted Article: A gain-of-function point mutation in mouse PDGFRβ causes osteopenia associated with intrinsic changes in skeletal stem cells that promote chondrogenesis over osteogenesis.
RESEARCH ARTICLES
DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as an Alk target in the Drosophila visceral mesoderm
Summary: Using targeted DamID (TaDa) to reveal Alk targets in the Drosophila visceral mesoderm identified the Kahuli (Kah) transcription factor, which plays a role in the regulation of embryonic midgut morphogenesis.
A 37 kb region upstream of brachyury comprising a notochord enhancer is essential for notochord and tail development
Summary: Genetic dissection of the mouse brachyury locus identifies a notochord enhancer and predicts additional control elements essential for trunk and tail development of the mouse embryo.
CFAP61 is required for sperm flagellum formation and male fertility in human and mouse
Summary: Analysis of Cfap91 knockout mice reveals that CFAP61 is required for the correct assembly of radial spoke components in spermatids and for axoneme stability, and is therefore crucial for spermatogenesis.
SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning
Highlighted Article: The transcriptional targets of SMAD4 in early limb buds are identified and the largely opposing impact of BMP and SHH signaling on early digit patterning and outgrowth is revealed.
The mechanosensitive channel Piezo1 cooperates with semaphorins to control neural crest migration
Highlighted Article: Neural crest directional and normal migration in vivo requires both chemical and mechanical regulation of Rac1 by Semaphorin 3A and Piezo1, respectively.
Repetitive accumulation of interstitial cells generates the branched structure of Cladonema medusa tentacles
Highlighted Article: A new comparative system for understanding branching morphogenesis is provided in the Cladonema pacificum medusa tentacle formation, showing its uniqueness and shared features with others.
TECHNIQUES AND RESOURCES
High-resolution dynamic mapping of the C. elegans intestinal brush border
Summary: Super-resolution imaging, transmission electron microscopy and genome editing in the developing nematode C. elegans build a high-resolution and dynamic localization map of known and new intestinal brush border markers.
Visualizing polymeric components that define distinct root barriers across plant lineages
Summary: A toolset enabling combined imaging of suberin and lignin, two cell wall polymers controlling molecular exchange between plant root and rhizosphere, is described and demonstrated to be robust across plant lineages.
Integrated molecular analysis identifies a conserved pericyte gene signature in zebrafish
Summary: An integrated molecular analysis in zebrafish identifies new molecular markers for pericytes.
From heterogeneous morphogenetic fields to homogeneous regions as a step towards understanding complex tissue dynamics
Summary: Tissue morphogenesis is driven by multiple mechanisms: this paper proposes a methodology to identify regions in the developing tissue, where each of the regions has distinctive cellular dynamics and deformation.
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
