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Issues

RESEARCH HIGHLIGHT

PERSPECTIVE

OBITUARY

HYPOTHESIS

Summary: A novel hypothesis is presented incorporating a dynamic view of transcriptional states to explain how neural crest cells generate their diverse repertoire of cell types.

HUMAN DEVELOPMENT

Highlighted Article: Given that KLF17 was shown to be sufficient, but not necessary, to establish naïve pluripotent hESCs, KLF17 might function as a peripheral regulator of human pluripotent stem cells.

STEM CELLS AND REGENERATION

Summary: This study reveals a new layer of regulation within the signaling network that controls differentiation of a Drosophila epithelial stem cell lineage.

RESEARCH ARTICLES

Highlighted Article: Dynamic WNT11 expression in the cecal region regulates enteric neural crest cell colonization of the colorectum, revealing an essential role of the ceca in avian enteric nervous system development.

Summary: Epigenetic machinery centered on a LncRNA and the BAF complex temporally controls cell cycle progression and the neurogenic program of neocortical intermediate progenitors.

Summary: This study describes the first visualization of a topographic map forming and maturing in a living animal and identifies the adhesion molecule Contactin 2 as a key regulator in that process.

TECHNIQUES AND RESOURCES

Summary: Signal amplification based on the mechanism of hybridization chain reaction enables multiplexed, quantitative, high-resolution imaging of protein and RNA targets in highly autofluorescent tissues.

Summary: Use of proximity biotin ligation to identify components of a Dynein localization complex and the development of a nanobody-based approach to identify the interactome of any GFP-tagged protein.

Summary: A comprehensive map of the transcriptional landscape of the first four chick branchial arches that defines a spatio-temporal reference resource during patterning of the vertebrate head and neck.

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