Issues
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Cover image
Cover Image
Cover: In toto 3D mesoSPIM image of a cleared Xenopus tropicalis embryo. Whole-mount staining for Col2a1 (red hot) shows the craniofacial cartilages. Nuclei were stained with Draq5 and combined with an autofluorescense signal excited at 488 nm (blue). See Research article by Naert et al. (dev199664).
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RESEARCH HIGHLIGHTS
INTERVIEWS
REVIEWS
It takes all kinds: heterogeneity among satellite cells and fibro-adipogenic progenitors during skeletal muscle regeneration
Summary: This Review summarizes recent single-cell, genetic and transplantation studies demonstrating heterogeneity of satellite cells and fibroadipogenic progenitors in skeletal muscle regeneration.
HUMAN DEVELOPMENT
Characterization of primary models of human trophoblast
Summary: Characterization of trophoblast organoids and trophoblast stem cells as exciting models of human placentation enables the selection of the most suitable system to address specific research questions.
STEM CELLS AND REGENERATION
NF-κB determines Paneth versus goblet cell fate decision in the small intestine
Highlighted Article: The transcription factor NF-κB, together with downstream Wnt and Sox9, is required for Paneth and goblet cell fate decisions and for maintenance of the small intestinal stem cell niche.
Cell-cell communication through FGF4 generates and maintains robust proportions of differentiated cell types in embryonic stem cells
Highlighted Article: Experiments in embryonic stem cells reveal how the coupling of cell fate decisions in a population leads to the self-organized differentiation of stable ratios of cell types.
RESEARCH REPORT
Aurora kinase B inhibits aurora kinase A to control maternal mRNA translation in mouse oocytes
Summary: This study demonstrates that, in mouse oocytes, AURKA is required for CPEB1-dependent translation, and it describes a new AURKB requirement to maintain translation levels through AURKA, a function crucial to generating euploid eggs.
RESEARCH ARTICLES
Alveolar progenitor differentiation and lactation depends on paracrine inhibition of Notch via ROBO1/CTNNB1/JAG1
Summary: This study demonstrates that Robo1/β-catenin/JAG1 signaling in basal epithelial cells regulates luminal Notch activity and alveolar progenitor differentiation, offering a non-hormonal way to target milk production and mitigate lactation insufficiency.
GAS1 is required for NOTCH-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium
Summary: GAS1 acts as co-receptor that integrates signaling by sonic hedgehog and NOTCH in neural progenitor cells, which are essential for controlling the differentiation of the forebrain neuroepithelium.
Optimal BR signalling is required for adequate cell wall orientation in the Arabidopsis root meristem
Summary: Both increased and reduced BR signalling strength results in altered cell wall orientation in the Arabidopsis root, uncoupled from whole-root growth control.
Zinc is an intracellular signal during sperm activation in Caenorhabditis elegans
Highlighted Article: Use of an ionophore to manipulate cytoplasmic zinc levels in nematode sperm reveals that zinc signaling is sufficient, but not always necessary, for sperm activation.
Deep learning is widely applicable to phenotyping embryonic development and disease
Highlighted Article: We used deep-learning tools to automate image analysis, including high-dimensional light-sheet images, of embryonic development and disease.
FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice
Summary: FAM71F1 interacts with RAB2A/B and regulates the formation of the acrosome in mice, the misregulation of which impacts male fertility.
Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle
Summary: In addition to their conserved roles in neuromuscular development of axial muscle in zebrafish, Agrin and Lrp4 also have secondary roles in constraining MuSK-dependent synapse formation in appendicular muscle.
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
