Issues

Summary: This Review discusses the different approaches available for using a new generation of self-organizing embryonic and cardiac organoids.

Summary: TRPM7 channels have a crucial developmental role in pancreatic progenitor cells. TRPM7 increases β-cell Mg²⁺ levels during proliferation and promotes β-cell proliferation under insulin resistant conditions.

Summary: Duplicated antagonistic signaling peptides orthologous to the Arabidopsis EPF2 and STOMAGEN ligands, which are essential for the precise control of stomatal lineage initiation,  are revealed in the grass model organism Brachypodium distachyon.

Summary: Mutations in ITPR1 cause aniridia in individuals with Gillespie syndrome. This study reveals that loss of ITPR1 leads to anterior eye segment tissue defects, especially in the iris and cornea.

Summary: The homeobox transcription factor TGIF1 is required for proper ovarian sex differentiation in chicken embryos, regulating development of the cortical and juxtacortical medulla, independently of the supporting cell sex lineage.

Highlighted Article: nubbin and the gap genes knirps and giant redundantly repress Krüppel expression during segmentation. Simultaneous knockdown of all three genes causes ectopic Krüppel expression and loss of abdominal segment identity.

Summary: The transcriptional regulator ZBTB20 acts in both progenitors and postmitotic cells to regulate cell fate specification of subtypes of callosal projection neurons and astrocytes in the mouse cortex.

Highlighted Article: Single-cell morphometrics reveals that notochord development in amphioxus, a basally branching chordate, is driven by a complex set of cellular behaviours characterised by specific trajectories of cell shape change.

Summary: Genetic dissection of the Irx family of transcription factors in zebrafish reveals diverse requirements in formation of the facial complex and separation of individual cartilage elements.

Summary: Formin 3 regulates the dendritic microtubule cytoskeleton and organelle localization, and is required for peripheral sensitivity to noxious heat, demonstrating mechanistic links between formin-mediated dendritic cytoskeletal regulation and nociceptive behavior.

Summary: Analysis of germ cell-specific Fis1 knockout mice and mitophagy reporter mice reveals that the mitochondrial dynamics gene Fis1 regulates mitochondrial morphology and turnover during spermatid maturation.

Summary: Lrig1 and Lrig3 act redundantly to ensure proper sensory axonal growth, epidermal innervation and cold nociception.