TRPM7 is a crucial regulator of pancreatic endocrine development and high-fat-diet-induced β-cell proliferation
Summary: TRPM7 channels have a crucial developmental role in pancreatic progenitor cells. TRPM7 increases β-cell Mg2+ levels during proliferation and promotes β-cell proliferation under insulin resistant conditions.
Summary: Duplicated antagonistic signaling peptides orthologous to the Arabidopsis EPF2 and STOMAGEN ligands, which are essential for the precise control of stomatal lineage initiation, are revealed in the grass model organism Brachypodium distachyon.
Summary: Mutations in ITPR1 cause aniridia in individuals with Gillespie syndrome. This study reveals that loss of ITPR1 leads to anterior eye segment tissue defects, especially in the iris and cornea.
The homeobox gene TGIF1 is required for chicken ovarian cortical development and generation of the juxtacortical medulla
Summary: The homeobox transcription factor TGIF1 is required for proper ovarian sex differentiation in chicken embryos, regulating development of the cortical and juxtacortical medulla, independently of the supporting cell sex lineage.
The neuroblast timer gene nubbin exhibits functional redundancy with gap genes to regulate segment identity in Tribolium
Highlighted Article: nubbin and the gap genes knirps and giant redundantly repress Krüppel expression during segmentation. Simultaneous knockdown of all three genes causes ectopic Krüppel expression and loss of abdominal segment identity.
ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex
Summary: The transcriptional regulator ZBTB20 acts in both progenitors and postmitotic cells to regulate cell fate specification of subtypes of callosal projection neurons and astrocytes in the mouse cortex.
Highlighted Article: Single-cell morphometrics reveals that notochord development in amphioxus, a basally branching chordate, is driven by a complex set of cellular behaviours characterised by specific trajectories of cell shape change.
Summary: Genetic dissection of the Irx family of transcription factors in zebrafish reveals diverse requirements in formation of the facial complex and separation of individual cartilage elements.
Formin 3 directs dendritic architecture via microtubule regulation and is required for somatosensory nociceptive behavior
Summary: Formin 3 regulates the dendritic microtubule cytoskeleton and organelle localization, and is required for peripheral sensitivity to noxious heat, demonstrating mechanistic links between formin-mediated dendritic cytoskeletal regulation and nociceptive behavior.
Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation
Summary: Analysis of germ cell-specific Fis1 knockout mice and mitophagy reporter mice reveals that the mitochondrial dynamics gene Fis1 regulates mitochondrial morphology and turnover during spermatid maturation.
Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation
Summary: Lrig1 and Lrig3 act redundantly to ensure proper sensory axonal growth, epidermal innervation and cold nociception.