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RESEARCH HIGHLIGHTS

SPOTLIGHT

Summary: This Spotlight article discusses the mechanisms that polyploid cardiomyocytes and their relationship with cardiac regeneration.

MEETING REVIEW

Summary: Highlights of the second EMBO-EMBL Symposium ‘Synthetic Morphogenesis: From Gene Circuits to Tissue Architecture’ held in March 2021.

REVIEW

Summary: This Review emphasizes that the general principles of embryonic development and tissue homeostasis are similar, and that interactions between these disciplines will be beneficial for both research fields.

RESEARCH REPORT

Summary: Using a temporospatially specific gain- and loss-of-function approach, this study reveals that Wnt/β-catenin signaling is crucial in early development of the mouse molar.

RESEARCH ARTICLES

Summary: Epithelial tissues heterozygous for a ribosomal protein gene, which causes a variety of developmental abnormalities in humans, ensure robust morphogenesis by suppressing JNK-mediated apoptosis via Yorkie in Drosophila.

Summary: MPDZ patterns the apical membrane of auditory hair cells, and defects in hair bundle morphogenesis coincide with severe hearing loss in Mpdz mutants.

Summary: Single-cell RNA sequencing identifies interactions of TCF4 with non-bHLH transcription factors linked to neurodevelopmental and neuropsychiatric disease in the regulation of interhemispheric projection neuron development.

Summary: Activation of the FOXO1-TP53INP1-p53-CDKN1A axis prevents G1/S progression in porcine ovarian somatic GCs during hypoxia.

Summary: This study reveals the significance of clathrin-mediated endocytosis in mammalian embryogenesis and the involvement of protein ubiquitylation in selective degradation of maternal membrane proteins during the oocyte-to-embryo transition.

Highlighted Article: How spatial information and temporal maturation contribute to the production of discrete neuronal types from a continuum of progenitors in the developing pallium.

Summary: PDGFRα signaling regulates gene expression through alternative RNA splicing; ablation in the murine neural crest lineage of a downstream effector of PDGFRα signaling, the RNA-binding protein Srsf3, results in midline facial clefting.

Highlighted Article: Glypican 4 controls the planar polarity of endodermal cells during early segmentation in the zebrafish by regulating the distribution of Cadherin 2 through Rab5c-mediated endocytosis.

Summary: VCC is a plasma membrane protein that controls the transition from pre-procambial into procambial cell fate during the formation of lateral vascular strands in Arabidopsis embryonic cotyledons.

Summary: This study indicates that the mechanism through which the cell wall controls cell fate and morphogenesis in plants involves regulation of the receptor kinase STRUBBELIG.

Summary: The BMP antagonist Grem1 is expressed by committed deep-layer glutamatergic neurons in the embryonic mouse cortex. Grem1 conditional knockout mice display cortical and behavioral abnormalities.

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