Issues
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Cover image
Cover Image
Cover: Normal development of the vascular system in a medaka stage-39 embryo (maximal intensity projection image) as depicted by the zFli:GFP reporter. Aberrant N-glycosylation leads to vascular abnormalities, craniofacial dysmorphisms and neuronal defects, as seen using a fish model developed to investigate a rare form of congenital disorder of glycosylation based on the genetics of a human patient. See Research article by Gücüm et al. (dev199385).
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RESEARCH HIGHLIGHTS
INTERVIEWS
MEETING REVIEW
Metabolic decisions in development and disease
Summary: This Meeting Review summarises the main themes and messages emerging from the virtual Keystone Symposia about ‘Metabolic decisions in development and disease’ on 24-25th March 2021.
REVIEWS
When form meets function: the cells and signals that shape the lymphatic vasculature during development
Summary: This Review looks at the recent discoveries in the field of developmental lymphangiogenesis and discusses their implications for understanding the development of the lymphatic vasculature and the aetiology of lymphatic vascular diseases.
The multiple facets of Cajal-Retzius neurons
Summary: By integrating the most recent data from public transcriptomic datasets, this Review aims to expose the heterogeneity of Cajal-Retzius neurons in terms of ontogenetic origins, migration, functions and death dynamics.
STEM CELLS AND REGENERATION
Universal principles of lineage architecture and stem cell identity in renewing tissues
Summary: Mathematical analysis of cell state trajectory networks demonstrates that self-renewing cell types must reside at the apex of every cell lineage hierarchy in homeostatic renewing tissues, and only there.
Secreted inhibitors drive the loss of regeneration competence in Xenopus limbs
Summary: Secreted inhibitors associated with chondrogenic progression inhibit AER cell formation and restrict limb regeneration potential.
longfin causes cis-ectopic expression of the kcnh2a ether-a-go-go K+ channel to autonomously prolong fin outgrowth
Summary: Ectopic kcnh2a underlies the classic longfin zebrafish mutant and links ion signaling within a growth-determining mesenchyme lineage to fin size control by tuning outgrowth periods rather than altering positional information.
RESEARCH REPORTS
Cantil: a previously unreported organ in wild-type Arabidopsis regulated by FT, ERECTA and heterotrimeric G proteins
Highlighted Article: Wild-type Arabidopsis form pedicel-supporting organs (cantils) in short photoperiods via delayed flowering and a discovered regulatory network comprising FLOWERING LOCUS T, ERECTA and the GPA1-AGB1-AGG3 heterotrimeric G protein complex subunits.
IP3-mediated Ca2+ signals regulate larval to pupal transition under nutrient stress through the H3K36 methyltransferase Set2
Summary: A positive-feedback loop between Ca2+ signaling and a histone modifier enhances gene expression in key larval neurons and drives larval-to-pupal transitions on a protein-deficient diet.
RESEARCH ARTICLES
Combinatorial patterns of graded RhoA activation and uniform F-actin depletion promote tissue curvature
Summary: Tissue-level F-actin and myosin patterning during Drosophila gastrulation is regulated by overlapping transcriptional patterns and modulated by RhoA signaling. This pattern regulates fold curvature of the ventral furrow.
Hypomorphic and hypermorphic mouse models of Fsip2 indicate its dosage-dependent roles in sperm tail and acrosome formation
Summary: RNA sequencing and proteomics analyses of Fsip2 transgenic mouse models reveal insights into the role of Fsip2 in sperm tail and acrosome formation, which may be crucial for fertility.
Piecemeal regulation of convergent neuronal lineages by bHLH transcription factors in Caenorhabditis elegans
Summary: The fate of similar neurons that are derived from distinct lineages is controlled by distinct bHLH factors controlling the expression of terminal selectors.
Mouse EWSR1 is crucial for spermatid post-meiotic transcription and spermiogenesis
Summary: The essential function of EWSR1, a commonly expressed gene, in the post-meiotic development of male germ cells leading to production of mature sperm.
Neural cell adhesion molecule is required for ventricular conduction system development
Highlighted Article: The cell adhesion molecule NCAM-1 and its post-translational modification by polysialylation are required for normal formation and function of the specialized ventricular conduction system.
Two distinct motifs for Zic-r.a drive specific gene expression in two cell lineages
Highlighted Article: A Zic transcription factor has two recognition motifs that are not divergent versions of a single motif. These motifs activate different sets of targets in different cell lineages of ascidian embryos.
A patient-based medaka alg2 mutant as a model for hypo-N-glycosylation
Highlighted Article: A fully rescuable, patient-based hypo-N-glycosylation ALG2 medaka model recapitulates the patient's multisystemic phenotypes, prominently in skeleton and neuronal tissue, allowing the cell type-specific impact of N-glycosylation to be investigated.
Regulation of UNC-40/DCC and UNC-6/Netrin by DAF-16 promotes functional rewiring of the injured axon
Summary: During the re-establishment of functional connectivity following nerve injury, the expression of UNC-40/DCC and UNC-6/Netrin is regulated in neuron and muscle, respectively, by the DAF-2-DAF-16 axis.
Opposing effects of Wnt/β-catenin signaling on epithelial and mesenchymal cell fate in the developing cochlea
Summary: The developing cochlea comprises spatially and lineally distinct populations of epithelial and mesenchymal cells. This study shows the opposing effects of aberrant Wnt/β-catenin signaling on cell fates of cochlear epithelial and mesenchymal cells.
Identification of in vivo Hox13-binding sites reveals an essential locus controlling zebrafish brachyury expression
Summary: A CUT&RUN screen for in vivo Hox13-binding sites in the zebrafish tailbud reveals a highly conserved enhancer element necessary for NMp expression of brachyury and body axis elongation.
TECHNIQUES AND RESOURCES
An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters
Summary: A complete set of seven zebrafish hox cluster loss-of-function alleles provides insights into the sub/neofunctionalization of vertebrate Hox clusters.
Interviews with Biologists @ 100 conference speakers

Explore our interviews with keynote speakers from the Biologists @ 100 conference, hosted to celebrate our publisher’s 100th anniversary, where we discuss climate change and biodiversity with Hans-Otto Pörtner and Jane Francis, health and disease with Charles Swanton and Sadaf Farooqi, and emerging technologies with Manu Prakash and Jennifer Lippincott-Schwartz.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues

Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 30 May 2025.
A case for broadening our view of mechanism in developmental biology

In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. Together with our preprint highlights service, preLights, these perspectives help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
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