Issues

Summary: Developmental geneticist Kathryn Anderson, who defined fundamental mechanisms underlying fly and mouse embryogenesis, is remembered by her former postdoc and friend, Tamara Caspary.

Summary: This Spotlight summarizes how cross-disciplinary approaches have advanced our understanding of the autonomous and non-autonomous control of organ growth in multiple species.

Summary: This Spotlight reveals the key concepts, advantages and limitations of machine learning, and discusses how these methods are being applied to problems in developmental biology.

Summary: This Review discusses advances in the field of lncRNA functions in animal development and physiology, with a particular focus on regulatory RNA sequence motifs.

Summary: This Review presents an historical perspective about the study of epithelial organization during development, discussing how and why simplified, but realistic, computational models are required to address key morphogenetic events.

Summary: A dissection-free method to identify proximity-based RNA-protein interactions in an in vivo stem cell population, enabling molecular analysis of these cells at unprecedented speed and resolution.

Highlighted Article: PECT1 regulates flowering in a florigen-independent manner by activating the expression of SVP in the shoot apical meristem and thus delays flowering

Highlighted Article:E2f1-null male mice have cryptorchidism and spermatogenic failure. After deletion of Wnt4 in germ cells of E2f1-null mice fertility improves, supporting the hypothesis that E2f1 represses Wnt4 in germ cells.

Summary: Using newly generated mouse genetic tools, we demonstrate the dynamic regulation of mesenchymal androgen signaling as cellular niches controlling prostate early development.

Summary: The zebrafish b paralog of colony-stimulating factor 1 receptor is an essential positive regulator of HSC-derived myelopoiesis, resulting in macrophage deficiency, including microglia, in adult mutant animals.

Summary: NANOS3 protects germ cells against apoptosis in the absence of NANOS2, but it cannot rescue NANOS2 function because of weaker binding ability.

Summary: The Notch pathway activation relies on the correct localization of the Notch signalling actors. We report that AP-1 and Stratum ensure the basolateral targeting of Notch during asymmetric cell division.

Summary: The Activin branch of the TGF-β superfamily regulates Drosophila larval body wall muscle size in all three spatial dimensions through differential control of sarcomeric building block production and assembly.

Summary: Cells lineages are specified in the mouse embryo already within the primitive streak in which Mesp1-positive mesoderm and Foxa2-positive endoderm are generated in a spatial and temporal sequence from unbiased progenitors.

Summary: Maize LBL1 and its functionally conserved Arabidopsis homologue AtSGS3 regulate root development, possibly by affecting auxin distribution and signalling, in a crosstalk with miR165/166 and their target ROLLED1/2.

Summary: Positive feedback between Meis and retinoic acid regulates axial skeleton patterning in the mouse embryo.