Cover: Polarising region grafts made to the anterior margin of a wing bud of a host chick embryo produce mirror-image duplications of the feather bud pattern, as shown by the black pigmentation. See Research article by Busby et al. (dev188821).
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
Once upon a dish: engineering multicellular systems
Summary: This Meeting Review summarizes the main results presented at the EMBL/IBEC Winter conference ‘Engineering Multicellular Systems’ held in Spain in February 2020.
Neuronal and glial regulation of CNS angiogenesis and barriergenesis
Summary: This Review discusses how neuronal and glial development affects CNS angiogenesis and barriergenesis, and how this might lead to new interventions to treat neurovascular pathologies.
STEM CELLS AND REGENERATION
Survival of Drosophila germline stem cells requires the chromatin-binding protein Barrier-to-autointegration factor
Summary: Emerin/Otefin, a Drosophila nuclear lamina LEM-D protein, plays a major role in localizing Barrier-to-autointegration factor to the nuclear lamina, a partnership that contributes to stem cell maintenance.
Aging induces aberrant state transition kinetics in murine muscle stem cells
Highlighted Article: Aged muscle stem cells display delayed activation dynamics, but retain a youthful activation trajectory, suggesting that changes to cell state dynamics might contribute to aging pathology.
ETHYLENE INSENSITIVE 3 suppresses plant de novo root regeneration from leaf explants and mediates age-regulated regeneration decline
Summary: Enhanced EIN3 activity in older plants suppresses WOX11/WOX5 activation to inhibit de novo root regeneration in detached Arabidopsis leaf explants.
WNT regulates programmed muscle remodeling through PLC-β and calcineurin in Caenorhabditis elegans males
Summary: Fluorescently tagged actin visualization, mutant analyses and Ca2+-based assays reveal the mechanisms that underpin muscle remodeling under a normal developmental program, which provides insights into how to control pathological remodeling.
A combinatorial code of transcription factors specifies subtypes of visual motion-sensing neurons in Drosophila
Summary: Morphological and transcriptomic analyses allowed the identification of a combinatorial code of transcription factors that controls the development of subtype-specific morphologies in motion-detecting neurons of the Drosophila visual system.
Transient and lineage-restricted requirement of Ebf3 for sternum ossification
Highlighted Article: Analysis of conditional and temporal knockout mice reveals roles of Ebf3 in the differentiation of lateral plate mesenchymal cells towards pre-osteoblasts during sternum ossification at the boundary of the lateral and somitic mesoderm.
Sonic hedgehog specifies flight feather positional information in avian wings
Highlighted Article: Embryonic Shh signalling integrates flight feather with digit specification in the chicken wing, providing insights into the evolution of avian flight.
TECHNIQUES AND RESOURCES
Endogenous CRISPR/Cas9 arrays for scalable whole-organism lineage tracing
Highlighted Article: We identify endogenous CRISPR/Cas9 arrays from wild-type genomes, making whole-organism lineage tracing more feasible in non-model species for which it is hard to generate transgenic animals.
MicroRNA profiling of mouse cortical progenitors and neurons reveals miR-486-5p as a regulator of neurogenesis
Summary: Use of a double reporter mouse line reveals miRNA profiles of progenitor cell types (proliferating and differentiating) and newborn neurons during mouse cortical development.
Development Journal Meeting 2023
We are delighted to announce that our 2023 Journal Meeting ‘Unconventional and Emerging Experimental Organisms in Cell and Developmental Biology’ will be held from 17-20 September 2023 at Wotton House, Surrey, UK. Find out more and register here.
Call for papers: Metabolic and Nutritional Control of Development and Regeneration
We are welcoming submissions for our next special issue, which will focus on metabolic and nutritional control of development and regeneration. Submission deadline: 15 May 2023.
preLights 5th Birthday webinar
preLights, our preprint highlighting service, is celebrating its 5th birthday this year. To mark the occasion, join us online on 14 March 2023 at 16:00 GMT for a discussion, led by four preLights alumni, on how to identify and navigate the challenges and opportunities while shaping your career as an early-career researcher.
Transitions in development: Daniel Grimes
Daniel Grimes’s lab studies the consequences of ciliary mutations, including left-right patterning defects and scoliosis. We interviewed Daniel to find out more about his career path, his experience of becoming a group leader and the influence of Jurassic Park.
Preprints in Development
As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context.