Issues

Summary: This Meeting Review summarizes the main results presented at the EMBL/IBEC Winter conference ‘Engineering Multicellular Systems’ held in Spain in February 2020.

Summary: This Review discusses how neuronal and glial development affects CNS angiogenesis and barriergenesis, and how this might lead to new interventions to treat neurovascular pathologies.

Summary: Emerin/Otefin, a Drosophila nuclear lamina LEM-D protein, plays a major role in localizing Barrier-to-autointegration factor to the nuclear lamina, a partnership that contributes to stem cell maintenance.

Highlighted Article: Aged muscle stem cells display delayed activation dynamics, but retain a youthful activation trajectory, suggesting that changes to cell state dynamics might contribute to aging pathology.

Summary: Enhanced EIN3 activity in older plants suppresses WOX11/WOX5 activation to inhibit de novo root regeneration in detached Arabidopsis leaf explants.

Summary: Fluorescently tagged actin visualization, mutant analyses and Ca²⁺-based assays reveal the mechanisms that underpin muscle remodeling under a normal developmental program, which provides insights into how to control pathological remodeling.

Summary: Morphological and transcriptomic analyses allowed the identification of a combinatorial code of transcription factors that controls the development of subtype-specific morphologies in motion-detecting neurons of the Drosophila visual system.

Highlighted Article: Analysis of conditional and temporal knockout mice reveals roles of Ebf3 in the differentiation of lateral plate mesenchymal cells towards pre-osteoblasts during sternum ossification at the boundary of the lateral and somitic mesoderm.

Highlighted Article: Embryonic Shh signalling integrates flight feather with digit specification in the chicken wing, providing insights into the evolution of avian flight.

Highlighted Article: We identify endogenous CRISPR/Cas9 arrays from wild-type genomes, making whole-organism lineage tracing more feasible in non-model species for which it is hard to generate transgenic animals.

Summary: Use of a double reporter mouse line reveals miRNA profiles of progenitor cell types (proliferating and differentiating) and newborn neurons during mouse cortical development.