Issues
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Cover image
Cover Image
Cover: Artistic rearrangement of leaf confocal micrographs displaying battery of fluorescently tagged cell fate determinants in response to injuries. Images created by Anju P. S., Dhanya Radhakrishnan and Abdul Kareem V. K. Artwork by Mabel Maria Mathew (Indian Institute of Science Education and Research, Thiruvananthapuram, India). See Research article by Radhakrishnan et al. (dev185710).
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RESEARCH HIGHLIGHTS
INTERVIEW
PRIMERS
Model systems for regeneration: Xenopus
Summary: This Primer gives an overview of Xenopus as a model system for studying regeneration, comparing the two species X. laevis and X. tropicalis, and highlighting how Xenopus studies have enhanced our understanding of the molecular mechanisms of regeneration.
SUMOylation in development and neurodegeneration
Summary: In this Primer, we review the roles of SUMO, a ubiquitin-like protein, in developmental processes such as signaling, epigenetic regulation, neurogenesis and neurodegeneration.
STEM CELLS AND REGENERATION
A coherent feed-forward loop drives vascular regeneration in damaged aerial organs of plants growing in a normal developmental context
Highlighted Article: The PLT-CUC2 module acts in a feed-forward loop to increase the local auxin biosynthesis at the wound site. This drives vascular regeneration in aerial organs of plants.
RESEARCH REPORTS
Epigenetic changes occur at decidualisation genes as a function of reproductive ageing in mice
Highlighted Article: Maternal age-induced epigenetic changes in the uterus interfere with the induction of decidualisation genes, and thereby impede the early gestational adaptations that are essential for a successful pregnancy.
Temporal control of Wnt signaling is required for habenular neuron diversity and brain asymmetry
Summary: Left-right asymmetric neurogenesis of the vertebrate habenula depends on tight control of Wnt/β-catenin signaling involving a Wif1-mediated regulatory feedback loop.
RESEARCH ARTICLES
Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development
Summary: Post-translational monoubiquitylation modification of key transcription factors plays a vital role in regulation of noradrenergic neuron development.
Canonical Wnt/β-catenin activity and differential epigenetic marks direct sexually dimorphic regulation of Irx3 and Irx5 in developing mouse gonads
Summary: Differential occupation of two enhancers defines sex-specific regulation of Irx3 and Irx5 in fetal gonads: repressor marks inhibit in testes, while active marks engage with β-catenin/TCF to stimulate in ovaries.
Auxin fluxes through plasmodesmata modify root-tip auxin distribution
Highlighted Article: A multicellular model of auxin transport in the Arabidopsis root tip reveals the importance of intercellular plasmodesmata in maintaining auxin pattern and fluxes.
Spatiotemporal control of cell growth by CUC3 shapes leaf margins
Summary: The evolution of serrations at the leaf margin requires a fine tuning of cell growth; the transcription factor CUC3 is crucial for maintaining local and transient repression of growth in a few sinus cells.
CXXC finger protein 1-mediated histone H3 lysine-4 trimethylation is essential for proper meiotic crossover formation in mice
Summary: Conditional knockout of Cxxc1 in mouse pre-meiotic germ cells led to a decrease in H3K4me3, dysregulation of crossover formation and meiotic arrest, revealing an essential role for CXXC1 in spermatogenesis and oogenesis.
Expression of E93 provides an instructive cue to control dynamic enhancer activity and chromatin accessibility during development
Summary: The temporal transcription factor E93 controls both activation and deactivation of different target enhancers in the same cells to respond to spatial cues through regulation of chromatin accessibility.
Human antigen R-regulated mRNA metabolism promotes the cell motility of migrating mouse neurons
Summary: Maintaining actin dynamics is crucial for cell motility. Post-transcriptional regulation plays a pivotal role in supporting actin dynamics during neuronal migration.
TECHNIQUES AND RESOURCES
Molecular and genetic regulation of pig pancreatic islet cell development
Highlighted Article: Transcriptional, signaling and cellular programs governing pig pancreatic islet development exhibit striking similarities to human islet ontogeny, providing a novel resource for advancing human islet replacement strategies.
A single cell transcriptome atlas of the developing zebrafish hindbrain
Summary: A single cell transcriptome at three stages of zebrafish hindbrain development provides a valuable resource for investigations of the patterning of neurogenesis and transition of progenitors to neuronal differentiation.
Development presents…

Development is delighted to host a webinar series showcasing the latest developmental biology and stem cell research. The webinars are held each month with talks from postdocs applying for independent positions as part of our Pathway to Independence programme. Visit Development presents... on the Node to see which stimulating topics are coming up in the next few months.
Meet our 2025 Pathway to Independence (PI) fellows

We are delighted to announce our third cohort of PI fellows - researchers whom we will be supporting as they transition from postdoc to Principal Investigator. Read about the eight talented fellows chosen, whom we're excited to be working with as they navigate the job market.
A case for broadening our view of mechanism in developmental biology

In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
Browse by subject
![Development logo - Browse by subject: Explore Development's content, now easily accessible by subject area. The ad has a black background with three vibrant scientific images: a developing embryo on the left, a green plant-like structure in the center, and a gastruloid (a circular cell with a bright pink center and blue outer ring) on the right. [Blue button: browse content].](https://cob.silverchair-cdn.com/ImageLibrary/Development/Snippets/2025_05_Dev_Browse-by-subject_600x230_Snippet.png?versionId=8993)
From cardiovascular development and regeneration to tissue engineering and organoids, Development’s browse by subject archive allows you to access the latest papers (from late 2024 onwards) on a particular field of interest. In addition to our curated subject collections, these subject pages allow readers to browse a broader range of papers organised by topic.