Issues
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Cover image
Cover Image
Cover: A cross-section of the small intestine in an embryonic day 14.5 Ryk knockout mouse (magenta, F-actin; cyan, nuclei). See Research article by Wang et al. (dev195388).
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RESEARCH HIGHLIGHTS
OBITUARY
INTERVIEW
REVIEWS
From head to tail: regionalization of the neural crest
Summary: Neural crest is regionalized into distinct cell populations along the anteroposterior axis. This Review explores how varied approaches have shaped our understanding of the developmental and evolutionary origins of this pattern.
Neural crest lineage analysis: from past to future trajectory
Summary: This Review outlines the major discoveries in neural crest lineage tracing and how these have been refined to extend beyond development to regeneration and cancer initiation.
The heart of the neural crest: cardiac neural crest cells in development and regeneration
Summary: This Review covers the recent reports that cardiac neural crest cells can adopt a cardiomyocyte cell fate and that these cells may play important roles in the cardiac regeneration response to injury.
HUMAN DEVELOPMENT
Human yolk sac-like haematopoiesis generates RUNX1-, GFI1- and/or GFI1B-dependent blood and SOX17-positive endothelium
Highlighted Article: The hierarchical requirements for RUNX1, GFI1 and/or GFI1B during early human haematopoiesis arising from a yolk sac-like haemogenic endothelial intermediate.
RESEARCH REPORT
An evolutionarily conserved Lhx2-Ldb1 interaction regulates the acquisition of hippocampal cell fate and regional identity
Summary: Similar to an Apterous-Chip mechanism that patterns the Drosophila wing blade, the interaction between mammalian orthologs Lhx2 and Ldb1 regulates multiple aspects of hippocampal development in the mouse.
RESEARCH ARTICLES
Perturbation analysis of a multi-morphogen Turing reaction-diffusion stripe patterning system reveals key regulatory interactions
Highlighted Article: Going beyond classic two-component Turing Reaction-Diffusion, this study uses inhibitors, modelling and developmental dynamics to define the FGF-Hh-Wnt-BMP network driving striped rugal patterning in the oral palate.
Vps13 is required for timely removal of nurse cell corpses
Summary: Vps13, a protein linked to membrane contact sites and lipid transfer, is required for the timely removal of bulky cell remnants after programmed cell death during Drosophila late oogenesis.
Proteolytic cleavage of Slit by the Tolkin protease converts an axon repulsion cue to an axon growth cue in vivo
Summary: The axon repellent Slit is proteolytically cleaved by Tok and the resulting Slit-N fragment promotes longitudinal axon growth, not repulsion, in vivo.
RYK-mediated filopodial pathfinding facilitates midgut elongation
Highlighted Article: Fetal gut elongation is crucial for proper postnatal nutrient absorption. Wnt5a, Ryk and Ror2 mouse mutants reveal that WNT5A receptors are important for rapid gut elongation.
ENPL-1, the Caenorhabditis elegans homolog of GRP94, promotes insulin secretion via regulation of proinsulin processing and maturation
Summary: Understanding the roles of ER chaperones in cell biology is of great interest. This Research article shows that ENPL-1 promotes insulin secretion in Caenorhabditis elegans via regulation of proinsulin processing.
The HK5 and HK6 cytokinin receptors mediate diverse developmental pathways in rice
Summary: Disrupting a subset of histidine kinase (HK) genes in Oryza sativa reveals that HK5 and HK6 act as cytokinin receptors with overlapping functions to regulate diverse aspects of rice growth and development.
Harmonization of L1CAM expression facilitates axon outgrowth and guidance of a motor neuron
Summary: Control of axon outgrowth and guidance by balancing expression of L1 cell adhesion molecules might be used in vertebrates to control brain development.
Insulin/IGF signaling and TORC1 promote vitellogenesis via inducing juvenile hormone biosynthesis in the American cockroach
Summary: A combination of classic physiology and modern molecular techniques revealed that insulin/IGF signaling and TORC1 activate juvenile hormone production, and thus juvenile hormone signaling promotes vitellogenesis in the American cockroach.
Plant homeodomain proteins provide a mechanism for how leaves grow wide
Highlighted Article: The NS1 homeodomain transcription factor regulates lateral organ outgrowth from shoot meristems and leaf primordial margins by repressing the expression of negative growth regulators.
Loss of the seipin gene perturbs eggshell formation in Caenorhabditis elegans
Summary: Mutagenic analyses reveal that seipin plays a crucial role in permeability barrier synthesis during embryogenesis in Caenorhabditis elegans, and loss of seipin results in osmotically sensitive and dysfunctional embryos.
Save the date - Human Development: Stem Cells, Models, Embryos

We will be hosting a 2026 Human Development: Stem Cells, Models, Embryos meeting. We have teamed up with the Wellcome-funded consortium, the Human Developmental Biology Initiative (HDBI) to co-organise this event, which will bring together researchers from around the world, united by an interest in understanding human developmental biology. Save the date for 7-9 September 2026 and register.
Development presents…

Development is delighted to host a webinar series showcasing the latest developmental biology and stem cell research. The webinars are held each month with talks from postdocs applying for independent positions as part of our Pathway to Independence programme. Visit Development presents... on the Node to see which stimulating topics are coming up in the next few months.
Meet our 2025 Pathway to Independence (PI) fellows

We are delighted to announce our third cohort of PI fellows - researchers whom we will be supporting as they transition from postdoc to Principal Investigator. Read about the eight talented fellows chosen, whom we're excited to be working with as they navigate the job market.
From bench to business

In this Perspective, researchers who have transitioned from academia to industry tell us how they have navigated patents, intellectual property, investors and biotechnology start-ups to bring new biological advances from the bench and into the boardroom.
Browse by subject
![Development logo - Browse by subject: Explore Development's content, now easily accessible by subject area. The ad has a black background with three vibrant scientific images: a developing embryo on the left, a green plant-like structure in the center, and a gastruloid (a circular cell with a bright pink center and blue outer ring) on the right. [Blue button: browse content].](https://cob.silverchair-cdn.com/ImageLibrary/Development/Snippets/2025_05_Dev_Browse-by-subject_600x230_Snippet.png?versionId=9135)
From cardiovascular development and regeneration to tissue engineering and organoids, Development’s browse by subject archive allows you to access the latest papers (from late 2024 onwards) on a particular field of interest. In addition to our curated subject collections, these subject pages allow readers to browse a broader range of papers organised by topic.