Issues

Summary: Trudi Schüpbach discusses her life in research, from genetic screens to computational modeling, and shares her advice for people considering a career in scientific research.

Summary: This Spotlight provides key insights into the lineage specification and developmental trajectory in mouse embryonic development from the perspective of the single cell transcriptome.

Summary: This Primer gives an overview of the structure and functions of ten-eleven translocation proteins highlighting their roles as transcriptional and post-transcriptional epigenetic regulators in early development and stem cells.

Summary: This Review gives an overview of our current understanding of mammalian tooth morphogenesis and discusses recent findings relating to the regulation of stem cell-based dental tissue regeneration and repair.

Summary: Trophoblast exposure to low levels of oxygen promotes transcriptional programmes that are consistent with the extravillous lineage, a cell state important in placental development and function.

Summary: Lack of epithelial stem cell renewal and deficient epithelial autophagy are the major causes of aging in Hydra oligactis, whereas lowering autophagy efficiency in the non-aging Hydra vulgaris induces an aging phenotype.

Summary: This study describes roles for the RNA processing factor Ars2 in diverse aspects of mammalian neurogenesis, and reveals its broad role as a chromatin factor in this context.

Summary: Wuho, a WD40 protein, interacts with Mei-p26, a TRIM-NHL protein, and regulates fate determination in germline stem cells and daughter cells.

Summary: Murine DUX regulates transcription in the first embryonic cell divisions but is not strictly essential for embryogenesis.

Summary: GDE3 inhibits oligodendrocyte precursor cell proliferation by stimulating CNTF signaling through release of the ligand-binding component of the CNTF receptor, CNTFRα.

Summary: The sub-functionalization of csf1r paralogous genes in teleost fish coincides with the evolution of a novel function in regulating pigmentation.

Summary: Genetic analyses of Fasciclin 2 isoforms reveal that expression of a secreted form of Fasciclin 2 rescues lethality in Fas2 mutants, pointing to novel mechanistic actions of this adhesion protein.

Summary: Mouse genetics and proteomics reveal essential roles of AKAP3 in the formation of sperm structure and motility and indicate that cellular morphogenesis of sperm during spermiogenesis is systemically coordinated.

Summary: Loss of JNK signaling causes cortical interneurons to disperse from migratory streams, prematurely enter the cortical plate and deposit abnormally in the cortical wall.

Summary: During postnatal lung development, two major mesenchymal cell types have different developmental fates: most alveolar myofibroblasts are cleared from the lung by phagocytic cells, while alveolar lipofibroblasts are retained into adulthood.

Summary: The transcription factor FOXO1 contributes to developing hierarchical lymphangiogenesis in the mouse-tail dermis by transcribing the CXCR4 chemokine receptor and controlling CXCL12-dependent cell migration and proliferation in lymphatic endothelium.