Summary: This Spotlight provides key insights into the lineage specification and developmental trajectory in mouse embryonic development from the perspective of the single cell transcriptome.
Summary: This Primer gives an overview of the structure and functions of ten-eleven translocation proteins highlighting their roles as transcriptional and post-transcriptional epigenetic regulators in early development and stem cells.
Summary: This Review gives an overview of our current understanding of mammalian tooth morphogenesis and discusses recent findings relating to the regulation of stem cell-based dental tissue regeneration and repair.
Low oxygen enhances trophoblast column growth by potentiating differentiation of the extravillous lineage and promoting LOX activity
Summary: Trophoblast exposure to low levels of oxygen promotes transcriptional programmes that are consistent with the extravillous lineage, a cell state important in placental development and function.
STEM CELLS AND REGENERATION
Summary: Lack of epithelial stem cell renewal and deficient epithelial autophagy are the major causes of aging in Hydra oligactis, whereas lowering autophagy efficiency in the non-aging Hydra vulgaris induces an aging phenotype.
Summary: This study describes roles for the RNA processing factor Ars2 in diverse aspects of mammalian neurogenesis, and reveals its broad role as a chromatin factor in this context.
Summary: Wuho, a WD40 protein, interacts with Mei-p26, a TRIM-NHL protein, and regulates fate determination in germline stem cells and daughter cells.
Summary: GDE3 inhibits oligodendrocyte precursor cell proliferation by stimulating CNTF signaling through release of the ligand-binding component of the CNTF receptor, CNTFRα.
Unique and non-redundant function of csf1r paralogues in regulation and evolution of post-embryonic development of the zebrafish
Summary: The sub-functionalization of csf1r paralogous genes in teleost fish coincides with the evolution of a novel function in regulating pigmentation.
Summary: Genetic analyses of Fasciclin 2 isoforms reveal that expression of a secreted form of Fasciclin 2 rescues lethality in Fas2 mutants, pointing to novel mechanistic actions of this adhesion protein.
Lack of AKAP3 disrupts integrity of the subcellular structure and proteome of mouse sperm and causes male sterility
Summary: Mouse genetics and proteomics reveal essential roles of AKAP3 in the formation of sperm structure and motility and indicate that cellular morphogenesis of sperm during spermiogenesis is systemically coordinated.
JNK signaling is required for proper tangential migration and laminar allocation of cortical interneurons
Summary: Loss of JNK signaling causes cortical interneurons to disperse from migratory streams, prematurely enter the cortical plate and deposit abnormally in the cortical wall.
Identification of a FGF18-expressing alveolar myofibroblast that is developmentally cleared during alveologenesis
Summary: During postnatal lung development, two major mesenchymal cell types have different developmental fates: most alveolar myofibroblasts are cleared from the lung by phagocytic cells, while alveolar lipofibroblasts are retained into adulthood.
Summary: The transcription factor FOXO1 contributes to developing hierarchical lymphangiogenesis in the mouse-tail dermis by transcribing the CXCR4 chemokine receptor and controlling CXCL12-dependent cell migration and proliferation in lymphatic endothelium.